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公开(公告)号：EP3277276B1
公开(公告)日：2020-11-04
申请号：EP16774100.8
申请日：2016-03-30
IPC分类号： A61K31/433 , A61K31/501 , A61K31/4245 , A61P31/12 , A61P35/00 , A61P37/00
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公开(公告)号：EP2925318A1
公开(公告)日：2015-10-07
申请号：EP13860670.2
申请日：2013-12-03
发明人： BENNETT, Mark, K. , GROSS, Matthew, I. , BROMLEY, Susan, D. , LI, Jim , CHEN, Lijing , GOYAL, Bindu , LAIDIG, Guy , STANTON, Timothy, Friend , SJOGREN, Eric, Brian
IPC分类号： A61K31/433 , A61K31/4245 , A61K31/501 , A61P35/00
CPC分类号： C07D417/14 , A61K31/337 , A61K31/4245 , A61K31/433 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/5377 , A61K31/573 , A61K31/69 , A61K31/704 , A61K38/07 , A61K45/06 , C07D285/135 , C07D417/06 , G01N33/5005 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57426 , G01N33/6812 , G01N2333/9015 , G01N2333/98 , G01N2800/52 , A61K2300/00
摘要： The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof and the methods of treating or preventing cancer using the compounds of the invention. Other aspects relate to methods of identifying a cancer patient that may benefit from treatment with a glutaminase inhibitor comprising determining the ratio of glutamate to glutamine, the ratio of glutaminase enzyme to glutamine synthetase or glutaminase activity in cancer cells of the patient.
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公开(公告)号：EP3359150A1
公开(公告)日：2018-08-15
申请号：EP16854166.2
申请日：2016-10-04
发明人： MOLINEAUX, Susan, M. , GROSS, Matthew, I , BROMLEY, Susan, D. , PARLATI, Francesco , BENNETT, Mark, K.
IPC分类号： A61K31/41 , A61K31/435 , A61P35/00 , A61P31/00 , A61P37/00
CPC分类号： A61K31/501 , A61K38/1774 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2818 , C07K16/2827 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an immuno-oncology therapeutic agent, such as an inhibitor of arginase, CTLA-4, indoleamine 2,3-dioxygenase, and/or PD-1/PD-L1.
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公开(公告)号：EP3277276A1
公开(公告)日：2018-02-07
申请号：EP16774100.8
申请日：2016-03-30
IPC分类号： A61K31/433 , A61K31/501 , A61K31/4245 , A61P31/12 , A61P35/00 , A61P37/00
摘要： In some aspects, the invention relates to a method of treating cancer, a myeloproliferative disease, an immunological disease, a neurological disease, or a viral infection, comprising orally administering a compound of formula I, formula II, formula III, formula IV, formula V, and/or formula VI, wherein the compound is administered with a meal (e.g., with food as defined herein) or in fed mode.
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