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公开(公告)号：EP2782917A1
公开(公告)日：2014-10-01
申请号：EP12795969.0
申请日：2012-11-19
发明人： DORSEY, Bruce D. , LEARN, Keith S. , MORRIS, Emma L. , OTT, Gregory R. , ROFFEY, Jonathan R. , SOUDY, Christelle N. , WAGNER, Jason C.
IPC分类号： C07D495/04 , C07D495/14 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , C07D495/14 , C07D495/20 , C07D519/00 , C07F7/0812
摘要： The present invention provides a compound of formula (I) or a salt thereof, wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.摘要翻译： 本发明提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。
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2.发明授权
公开(公告)号：EP2782917B1
公开(公告)日：2016-03-02
申请号：EP12795969.0
申请日：2012-11-19
发明人： DORSEY, Bruce D. , LEARN, Keith S. , MORRIS, Emma L. , OTT, Gregory R. , ROFFEY, Jonathan R. , SOUDY, Christelle N. , WAGNER, Jason C.
IPC分类号： C07D495/04 , C07D495/14 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , C07D495/14 , C07D495/20 , C07D519/00 , C07F7/0812
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3.发明公开AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C 审中-公开AZAQUINAZOLININHIBITOREN VON ATYPISCHER PROTEINKINASE C
公开(公告)号：EP3129372A1
公开(公告)日：2017-02-15
申请号：EP15717317.0
申请日：2015-03-25
发明人： DORSEY, Bruce D. , DUGAN, Benjamin J. , FOWLER, Katherine M. , HUDKINS, Robert L. , MESAROS, Eugen F. , MONCK, Nathaniel Jt , MORRIS, Emma L. , OLOWOYE, Ikeoluwa , OTT, Gregory R. , PAVE, Gregoire A. , ROFFEY, Jonathan R.A. , SOUDY, Christelle N. , ZIFICSAK, Craig A. , ZULLI, Allison L.
IPC分类号： C07D471/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided.
摘要翻译： 本申请提供式（I）化合物和/或其盐，其中R 1，G和X如本文所定义。 式（I）化合物和/或其盐具有PKC抑制活性，可用于治疗增殖性疾病。 还提供了包含式（I）化合物和/或其盐的组合物。
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公开(公告)号：EP3048106A1
公开(公告)日：2016-07-27
申请号：EP15196784.1
申请日：2012-11-19
发明人： DORSEY, Bruce D. , LEARN, Keith S. , MORRIS, Emma L. , OTT, Gregory R. , ROFFEY, Jonathan R. , SOUDY, Christelle N. , WAGNER, Jason C.
IPC分类号： C07D495/04 , C07D495/14 , A61K31/519 , A61P35/00
摘要： The present invention provides a compound of formula (I)
or a salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, G, M, Q and X are as defined herein. The compound of formula (I) and its salts has aPKC inhibitory activity, and may be used to treat proliferative disorders.摘要翻译： 本发明提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：EP3048106B1
公开(公告)日：2019-11-06
申请号：EP15196784.1
申请日：2012-11-19
发明人： DORSEY, Bruce D. , LEARN, Keith S. , MORRIS, Emma L. , OTT, Gregory R. , ROFFEY, Jonathan R. , SOUDY, Christelle N. , WAGNER, Jason C.
IPC分类号： C07D495/04 , C07D495/14 , A61K31/519 , A61P35/00
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公开(公告)号：EP2376491B1
公开(公告)日：2015-03-04
申请号：EP09775073.1
申请日：2009-12-21
申请人： Cephalon, Inc.
发明人： BRESLIN, Henry J. , CHATTERJEE, Sankar , DIEBOLD, James L. , DORSEY, Bruce D. , DUNN, Derek , GINGRICH, Diane E. , HOSTETLER, Greg A. , HUDKINS, Robert L. , HUNTER, Rachael , JOSEF, Kurt , LISKO, Joseph , MESAROS, Eugen F. , MILKIEWICZ, Karen L. , OTT, Gregory R. , SUNDAR, Babu G. , THEROFF, Jay P. , THIEU, Tho , TRIPATHY, Rabindranath , UNDERINER, Theodore L. , WEINBERG, Linda , WELLS, Gregory J. , ZIFICSAK, Craig A.
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
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公开(公告)号：EP2376491A1
公开(公告)日：2011-10-19
申请号：EP09775073.1
申请日：2009-12-21
申请人： Cephalon, Inc.
发明人： BRESLIN, Henry J. , CHATTERJEE, Sankar , DIEBOLD, James L. , DORSEY, Bruce D. , DUNN, Derek , GINGRICH, Diane E. , HOSTETLER, Greg A. , HUDKINS, Robert L. , HUNTER, Rachael , JOSEF, Kurt , LISKO, Joseph , MESAROS, Eugen F. , MILKIEWICZ, Karen L. , OTT, Gregory R. , SUNDAR, Babu G. , THEROFF, Jay P. , THIEU, Tho , TRIPATHY, Rabindranath , UNDERINER, Theodore L. , WEINBERG, Linda , WELLS, Gregory J. , ZIFICSAK, Craig A.
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula (I) or a salt form thereof, wherein Q
1 , Q
2 , Q
3 , and Q
4 are as defined herein. The compound of formula (I) has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.-
8.发明公开
公开(公告)号：EP2438066A2
公开(公告)日：2012-04-11
申请号：EP10724213.3
申请日：2010-06-04
申请人： Cephalon, Inc.
发明人： CURRY, Matthew A. , DORSEY, Bruce D. , DUGAN, Benjamin J. , GINGRICH, Diane E. , MESAROS, Eugen F. , MILKIEWICZ, Karen L.
IPC分类号： C07D471/04 , A61K31/4196 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： This application relates to compounds of the general Formula I and salts thereof, wherein X, R
1A , R
1B , R
2 , R
3 , R
4 , and R
5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.
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