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公开(公告)号：EP4201939A1
公开(公告)日：2023-06-28
申请号：EP22211485.2
申请日：2019-04-12
发明人： BELLENIE, Benjamin Richard , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , HUCKVALE, Rosemary , COLLIE, Gavin , MENICONI, Mirco , BRENNAN, Alfie , LLOYD, Matthew Garth
IPC分类号： C07D498/04 , C07D498/08 , C07D498/20 , C07D513/04 , C07D471/04 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K31/5383 , A61P35/00
摘要： The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity:
wherein X 1 , X 2 , R 1 , R 2 , R 30 , R 31 and Ring A are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.-
公开(公告)号：EP4374858A3
公开(公告)日：2024-08-21
申请号：EP24150697.1
申请日：2018-05-25
发明人： BELLENIE, Benjamin Richard , CARTER, Michael Keith , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , LLOYD, Matthew Garth , VARELA RODRÍGUEZ, Ana , WOODWARD, Hannah , INNOCENTI, Paolo
IPC分类号： A61P35/00 , C07D401/12 , C07D403/12 , C07D413/14 , C07D403/14 , C07D409/14 , C07D417/14 , A61K31/4184
CPC分类号： C07D403/12 , C07D413/14 , C07D401/12 , C07D403/14 , C07D409/14 , C07D417/14 , A61P35/00
摘要： The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity:
wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.-
公开(公告)号：EP4374858A2
公开(公告)日：2024-05-29
申请号：EP24150697.1
申请日：2018-05-25
发明人： BELLENIE, Benjamin Richard , CARTER, Michael Keith , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , LLOYD, Matthew Garth , VARELA RODRÍGUEZ, Ana , WOODWARD, Hannah , INNOCENTI, Paolo
IPC分类号： A61K31/4184
CPC分类号： C07D403/12 , C07D413/14 , C07D401/12 , C07D403/14 , C07D409/14 , C07D417/14 , A61P35/00
摘要： The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity:
wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.-
公开(公告)号：EP3630291A1
公开(公告)日：2020-04-08
申请号：EP18730042.1
申请日：2018-05-25
发明人： BELLENIE, Benjamin Richard , CARTER, Michael Keith , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , LLOYD, Matthew Garth , VARELA RODRÍGUEZ, Ana , WOODWARD, Hannah , INNOCENTI, Paolo
IPC分类号： A61P35/00 , C07D401/12 , C07D403/12 , C07D413/14 , C07D403/14 , C07D409/14 , C07D417/14 , A61K31/4184
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公开(公告)号：EP4371562A3
公开(公告)日：2024-08-14
申请号：EP24150698.9
申请日：2018-05-25
发明人： BELLENIE, Benjamin Richard , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , HUCKVALE, Rosemary , LLOYD, Matthew Garth
IPC分类号： C07D403/12 , C07D413/14 , C07D215/42 , C07D401/12 , C07D403/14 , C07D407/14 , C07D413/12 , A61P35/00 , A61K31/4704
CPC分类号： C07D403/12 , C07D413/14 , C07D215/42 , C07D401/12 , C07D403/14 , C07D407/14 , C07D413/12 , A61P35/00
摘要： The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity:
wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.-
公开(公告)号：EP4371562A2
公开(公告)日：2024-05-22
申请号：EP24150698.9
申请日：2018-05-25
发明人： BELLENIE, Benjamin Richard , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , HUCKVALE, Rosemary , LLOYD, Matthew Garth
IPC分类号： A61K31/4704
CPC分类号： C07D403/12 , C07D413/14 , C07D215/42 , C07D401/12 , C07D403/14 , C07D407/14 , C07D413/12 , A61P35/00
摘要： The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity:
wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.-
公开(公告)号：EP4045510A1
公开(公告)日：2022-08-24
申请号：EP20793780.6
申请日：2020-10-14
发明人： BELLENIE, Benjamin Richard , BRENNAN, Alfie , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HARNDEN, Alice Claire , HOELDER, Swen , HUCKVALE, Rosemary
IPC分类号： C07D498/04 , A61K31/553 , A61P35/00
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公开(公告)号：EP3774817A1
公开(公告)日：2021-02-17
申请号：EP19718834.5
申请日：2019-04-12
发明人： BELLENIE, Benjamin Richard , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , HUCKVALE, Rosemary , COLLIE, Gavin , MENICONI, Mirco , BRENNAN, Alfie , LLOYD, Matthew Garth
IPC分类号： C07D498/04 , C07D498/08 , C07D498/20 , C07D513/04 , C07D471/04 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K31/5383 , A61P35/00
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公开(公告)号：EP3630749A1
公开(公告)日：2020-04-08
申请号：EP18730039.7
申请日：2018-05-25
申请人： Cancer Research Technology Limited , The Institute of Cancer Research : The Royal Cancer Hospital
发明人： BELLENIE, Benjamin Richard , CHEUNG, Kwai Ming Jack , DAVIS, Owen Alexander , HOELDER, Swen , HUCKVALE, Rosemary , LLOYD, Matthew Garth
IPC分类号： C07D403/12 , C07D413/14 , C07D215/42 , C07D401/12 , C07D403/14 , C07D407/14 , C07D413/12 , A61P35/00 , A61K31/4704
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