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公开(公告)号：EP3533795A1
公开(公告)日：2019-09-04
申请号：EP17865551.0
申请日：2017-10-25
发明人： SAWA, Masaaki , ASAMITSU, Yuko , UNO, Yuko , OMURA, Satoshi , OTOGURO, Kazuhiko , IWATSUKI, Masato , ISHIYAMA, Aki , HOKARI, Rei
IPC分类号： C07D471/04 , A61K31/506 , A61K31/5377 , A61P33/06 , C07D491/056 , C07D491/107
摘要： The present invention provides a novel 2,4,6-substituted pyrimidine derivative, which is a compound represented by formula (I) (in the formula, ring A is a 6-membered heteroaryl group having at least one N atom optionally substituted with R1, R2, and R3; Z is an optionally substituted alkoxy group, an optionally substituted amino group, an optionally substituted heterocycloalkyl group, or an optionally substituted heteroaryl group; and R1, R2, and R3 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted heterocycloalkyloxy group, an optionally substituted phenoxy group, an optionally substituted amino group, a nitro group, and a hydroxy group) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP2855470B1
公开(公告)日：2018-10-17
申请号：EP13729492.2
申请日：2013-05-22
发明人： SAWA, Masaaki , MORIYAMA, Hideki , YAMADA, Tesshi , SHITASHIGE, Miki , KAWASE, Yusuke , UNO, Yuko
IPC分类号： C07D417/12 , C07D417/14 , C07D277/56 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP2855470A1
公开(公告)日：2015-04-08
申请号：EP13729492.2
申请日：2013-05-22
发明人： SAWA, Masaaki , MORIYAMA, Hideki , YAMADA, Tesshi , SHITASHIGE, Miki , KAWASE, Yusuke , UNO, Yuko
IPC分类号： C07D417/12 , C07D417/14 , C07D277/56 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及抑制Traf2-和Nck相互作用激酶（TNIK）的新型双环噻唑化合物，并且因此可用作给予癌症患者的TNIK抑制剂，特别是用于固体癌症患者如结肠直肠癌，胰腺癌， 小细胞肺癌，前列腺癌或乳腺癌。 双环噻唑化合物由下式（I）表示。 （其中R 1，R 2，R 3和Q如说明书中所定义）或其药学上可接受的盐。
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公开(公告)号：EP3078660A1
公开(公告)日：2016-10-12
申请号：EP14868296.6
申请日：2014-12-05
IPC分类号： C07D403/12 , A61K31/517 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D413/12 , C07D417/12
CPC分类号： C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a quinazoline derivative represented by the following formula (I):
wherein R 1 and R 2 represent a hydrogen atom, a halogen atom, or a lower alkyl group optionally having a substituent; Z represents a cycloalkyl group having a substituent or a cycloalkenyl group having a substituent; and Q represents a bicyclic heteroaryl group optionally having a substituent, or a pharmaceutically acceptable salt thereof. Since the compound has an inhibitory effect on the Wnt/β-catenin signaling pathway and exhibits an antitumor effect, it is useful as a medicine.
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