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公开(公告)号：EP2364149B1
公开(公告)日：2014-05-07
申请号：EP09796056.1
申请日：2009-11-30
IPC分类号： A61K31/426 , C07D277/56 , A61P35/00
CPC分类号： C07D277/56 , A61K9/1652 , A61K9/2054 , A61K9/4858
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公开(公告)号：EP2364149A1
公开(公告)日：2011-09-14
申请号：EP09796056.1
申请日：2009-11-30
IPC分类号： A61K31/426 , C07D277/56 , A61P35/00
CPC分类号： C07D277/56 , A61K9/1652 , A61K9/2054 , A61K9/4858
摘要： The present invention relates to Traf2- and Nck-interacting kinase (TNIK) inhibitors, pharmaceutical compositions, and methods for the treatment of cancer patients with TNIK inhibitors. And the present invention relates to a novel aminothiazole derivatives. The TNIK inhibitors are showed by a next formula (I). (I) Wherein R1, R2, R3, R4, R5 and R6 represent independently a hydrogen atom or a substituent group.
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公开(公告)号：EP2855470B1
公开(公告)日：2018-10-17
申请号：EP13729492.2
申请日：2013-05-22
发明人： SAWA, Masaaki , MORIYAMA, Hideki , YAMADA, Tesshi , SHITASHIGE, Miki , KAWASE, Yusuke , UNO, Yuko
IPC分类号： C07D417/12 , C07D417/14 , C07D277/56 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP2855470A1
公开(公告)日：2015-04-08
申请号：EP13729492.2
申请日：2013-05-22
发明人： SAWA, Masaaki , MORIYAMA, Hideki , YAMADA, Tesshi , SHITASHIGE, Miki , KAWASE, Yusuke , UNO, Yuko
IPC分类号： C07D417/12 , C07D417/14 , C07D277/56 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及抑制Traf2-和Nck相互作用激酶（TNIK）的新型双环噻唑化合物，并且因此可用作给予癌症患者的TNIK抑制剂，特别是用于固体癌症患者如结肠直肠癌，胰腺癌， 小细胞肺癌，前列腺癌或乳腺癌。 双环噻唑化合物由下式（I）表示。 （其中R 1，R 2，R 3和Q如说明书中所定义）或其药学上可接受的盐。
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公开(公告)号：EP3078660A1
公开(公告)日：2016-10-12
申请号：EP14868296.6
申请日：2014-12-05
IPC分类号： C07D403/12 , A61K31/517 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D413/12 , C07D417/12
CPC分类号： C07D403/12 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a quinazoline derivative represented by the following formula (I):
wherein R 1 and R 2 represent a hydrogen atom, a halogen atom, or a lower alkyl group optionally having a substituent; Z represents a cycloalkyl group having a substituent or a cycloalkenyl group having a substituent; and Q represents a bicyclic heteroaryl group optionally having a substituent, or a pharmaceutically acceptable salt thereof. Since the compound has an inhibitory effect on the Wnt/β-catenin signaling pathway and exhibits an antitumor effect, it is useful as a medicine.-
公开(公告)号：EP2754713B1
公开(公告)日：2019-07-10
申请号：EP11872034.1
申请日：2011-09-09
发明人： SHINAGAWA, Shingo , ITO, Kazunari , TOKASHIKI, Yoshimi , MIYAMOTO, Tomoaki , HONDA, Kazufumi , YAMADA, Tesshi
IPC分类号： C12N15/02 , A61K39/395 , A61K45/00 , A61K48/00 , C07K16/18 , C12N5/10 , C12P21/08 , C12Q1/68 , G01N33/574 , C07K16/30 , C12N5/16 , C12N15/113
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7.发明公开METHOD FOR DETECTING PANCREATIC TUMOR, ANTIBODY, AND PANCREATIC TUMOR DETECTION KIT 审中-公开VERFAHREN ZUM NACHWEIS VON PANKREASTUMOR，ANTIKÖRPERUND NACHWEISKITFÜRPANKREASTUMOR
公开(公告)号：EP3054298A1
公开(公告)日：2016-08-10
申请号：EP14850747.8
申请日：2014-09-30
发明人： SANADA, Mitsuaki , KOBAYASHI, Michimoto , TAKAYAMA, Aiko , SASAJIMA, Yoshiyuki , JUNG, Giman , YAMADA, Tesshi , HONDA, Kazufumi
IPC分类号： G01N33/574 , C07K16/18 , C12N15/02 , C12P21/08
CPC分类号： G01N33/57438 , C07K16/18 , C07K16/303 , C07K2317/34 , C07K2317/565 , G01N33/577 , G01N2333/47 , G01N2333/775
摘要： It is intended to provide a method for detecting a pancreatic tumor (pancreatic cancer or benign pancreatic tumor) with low invasiveness to a test subject and with high detection sensitivity and accuracy. The present invention provides a method for detecting a pancreatic tumor by measuring the amounts of APOA2 protein variants in a sample of a test subject using anti-APOA2 antibodies, anti-APOA2 antibodies for use in the method, and a kit for the detection of a pancreatic tumor, comprising the antibodies.
摘要翻译： 旨在提供一种用于检测对受试者具有低侵袭性并具有高检测灵敏度和准确性的胰腺肿瘤（胰腺癌或良性胰腺肿瘤）的方法。 本发明提供了一种通过使用抗APOA2抗体测量受试者样品中APOA2蛋白变体的量，用于该方法的抗APOA2抗体以及用于检测胰腺癌的试剂盒来检测胰腺肿瘤的方法 胰腺肿瘤，包含抗体。
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公开(公告)号：EP2246431B1
公开(公告)日：2014-12-31
申请号：EP09713312.8
申请日：2009-02-20
CPC分类号： G01N33/5011 , C12Q1/485 , G01N2333/91215
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9.发明公开METHOD FOR DETECTING BILIARY TRACT CANCER AND BILIARY TRACT CANCER DETECTION KIT 审中-公开检测胆道癌和胆道癌检测试剂盒的方法
公开(公告)号：EP3252474A1
公开(公告)日：2017-12-06
申请号：EP16743298.8
申请日：2016-01-25
发明人： SANADA, Mitsuaki , KOBAYASHI, Michimoto , TAKAYAMA, Aiko , SASAJIMA, Yoshiyuki , JUNG, Giman , YAMADA, Tesshi , HONDA, Kazufumi
IPC分类号： G01N33/574 , G01N33/53 , G01N33/577
摘要： The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.
摘要翻译： 本发明提供了一种检测胆道癌的方法，通过用抗-APOA2抗体测量测试样品中APOA2蛋白变体的量，用于上述方法的抗-APOA2抗体和用于胆道癌的检测试剂盒包括 以上抗体。
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公开(公告)号：EP3252474B1
公开(公告)日：2020-10-21
申请号：EP16743298.8
申请日：2016-01-25
发明人： SANADA, Mitsuaki , KOBAYASHI, Michimoto , TAKAYAMA, Aiko , SASAJIMA, Yoshiyuki , JUNG, Giman , YAMADA, Tesshi , HONDA, Kazufumi
IPC分类号： G01N33/574 , G01N33/53 , G01N33/577
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