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公开(公告)号：EP3913065A1
公开(公告)日：2021-11-24
申请号：EP21164008.1
申请日：2012-04-06
摘要： The present invention relates to γ-PNA monomers according to Formula I where substituent groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , B and P are defined as set forth in the specification. The invention also provides methodology for synthesizing compounds according to Formula I and methodology for synthesizing PNA oligomers that incorporate one or more Formula I monomers.
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公开(公告)号：EP3428287A1
公开(公告)日：2019-01-16
申请号：EP18187994.1
申请日：2012-04-06
摘要： The present invention relates to γ-PNA monomers according to Formula I where substituent groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , B and P are defined as set forth in the specification. The invention also provides methodology for synthesizing compounds according to Formula I and methodology for synthesizing PNA oligomers that incorporate one or more Formula I monomers.
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4.发明公开
公开(公告)号：EP3803398A1
公开(公告)日：2021-04-14
申请号：EP19815519.4
申请日：2019-06-07
发明人： LY, Danith, H. , THADKE, Shivaji, A. , SHAIKH, Ashif, Y. , HSIEH, Wei-Che , NAKHI, Ali , PERERA, J. Dinithi
IPC分类号： G01N33/53 , G01N33/543
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公开(公告)号：EP3416976A2
公开(公告)日：2018-12-26
申请号：EP17711024.4
申请日：2017-02-16
发明人： SALTZMAN, W., Mark , GLAZER, Peter , BAHAL, Raman , MCNEER, Nicole, Ali , LY, Danith, H. , QUIJANO, Elias
IPC分类号： C07K14/00
CPC分类号： C12N15/907 , A61K9/1647 , A61K48/005 , C07K14/003 , C12N15/102 , C12N15/11 , C12N15/111 , C12N15/113 , C12N2310/15 , C12N2310/152 , C12N2310/318 , C12N2310/3181 , C12N2310/334 , C12N2310/351 , C12N2310/3519
摘要： Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing composition such as triplex-forming oligonucleotides, CRISPR, zinc finger nucleases, TALENS, or others, in combination with a gene modification potentiating agent such as stem cell factor (SCF), a CHK1 or ATR inhibitor, or a combination thereof. A particular preferred gene editing composition is triplex-forming peptide nucleic acids (PNAs) substituted at the γ position for increased DNA binding affinity. Nanoparticle compositions for intracellular delivery of the gene editing composition are also provided and particular advantageous for use with in vivo applications.
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公开(公告)号：EP3728206A1
公开(公告)日：2020-10-28
申请号：EP18891446.9
申请日：2018-12-21
发明人： LY, Danith, H. , HSIEH, Wei-Che , BAHAL, Raman
IPC分类号： C07D239/47 , C07D239/54 , C07D251/16
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公开(公告)号：EP2694683B1
公开(公告)日：2019-08-28
申请号：EP12767656.7
申请日：2012-04-06
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公开(公告)号：EP3523284A1
公开(公告)日：2019-08-14
申请号：EP17854112.4
申请日：2017-09-26
发明人： LY, Danith, H. , THADKE, Shivaji , NAKHI, Ali , PERERA, Dinithi
IPC分类号： C07D239/47 , C07D239/54 , C07D251/16 , C07D471/04 , C07D475/08 , C07D487/04 , C07D487/16 , C07H1/06 , C07H21/04 , C07K14/00 , G01N33/53 , C12N15/113
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9.发明公开CONFORMATIONALLY-PREORGANIZED, MiniPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS 审中-公开构象预组织MINIPEG含GAMMA肽核酸
公开(公告)号：EP2694683A2
公开(公告)日：2014-02-12
申请号：EP12767656.7
申请日：2012-04-06
CPC分类号： C07K14/003 , A61K47/60 , C07C229/12 , C07C271/20 , C07D239/47 , C07D239/54 , C07D473/18 , C07D473/34 , C07K1/04 , C07K1/08 , C08G69/10
摘要： The present invention relates to ³-PNA monomers according to Formula I where substituent groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , B and P are defined as set forth in the specification. The invention also provides methodology for synthesizing compounds according to Formula I and methodology for synthesizing PNA oligomers that incorporate one or more Formula I monomers.
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