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1.发明授权DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS 有权DIFLUORLACTAMVERBINDUNGEN AS EP4受体选择性激动剂FOR USE IN EP4介导的疾病和病症的治疗
公开(公告)号：EP2875022B1
公开(公告)日：2016-10-12
申请号：EP13745744.6
申请日：2013-07-19
发明人： BARRETT, Stephen, Douglas , CISKE, Fred, Lawrence , COLOMBO, Joseph, Michael , ENDRES, Gregory, William , GERMAIN, Bradlee, David , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , MAXEY, Kirk, M.
IPC分类号： C07D409/06 , C07D207/26 , C07D403/12 , C07D207/20 , A61K31/4015 , A61K31/4025 , A61P27/02 , A61P27/06 , A61P25/02 , A61P17/14 , A61P19/10
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4025 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L27/58 , A61L2300/412 , A61L2300/604 , A61L2430/02 , C07D207/26 , C07D409/06
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2.发明公开DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS 有权用于EP4介导的骨关节病和病症的二氟内酰胺组合物
公开(公告)号：EP2874620A1
公开(公告)日：2015-05-27
申请号：EP13745254.6
申请日：2013-07-19
发明人： BARRETT, Stephen, Douglas , CISKE, Fred, Lawrence , COLOMBO, Joseph, Michael , ENDRES, Gregory, William , GERMAIN, Bradlee, David , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , OWEN, Thomas, Allen , O'MALLEY, James, Paul
IPC分类号： A61K31/4015 , A61K31/4025 , A61P19/10 , A61P19/08
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4025 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L27/58 , A61L2300/412 , A61L2300/604 , A61L2430/02 , C07D207/26 , C07D409/06
摘要： Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L
1 , L
2 , L
4 , R
1 , R
4 , R
5 , R
6 , and s are as defined in the specification.摘要翻译： 本文公开了通过施用式（I）化合物或包含式（I）化合物和药学上可接受的载体的组合物治疗骨质疏松症，骨折，骨损失和增加骨密度的组合物和方法，其中L 1，L 2，L 4，R 1，R 4，R 5，R 6和s如说明书中所定义。
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公开(公告)号：EP3235817B1
公开(公告)日：2018-12-12
申请号：EP17169751.9
申请日：2014-03-14
发明人： BARRETT, Stephen, Douglas , COLOMBO, Joseph, Michael , GERMAIN, Bradlee, David , ENDRES, Gregory, William , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , CISKE, Fred, Lawrence , MAXEY, Kirk, M. , O'MALLEY, James, Paul , OWEN, Thomas, Allen
IPC分类号： C07D417/06 , C07D207/26 , A61K31/427 , A61P27/06
CPC分类号： C07D207/12 , C07D207/26 , C07D409/06 , C07D417/06
摘要： Disclosed herein are compounds of formula (I) wherein L 1 , L 2 , L 3 , L 4 , R 1 , R 4 , R 5 , R 6 , and s are as defined in the specification. Compounds of formula (I) are EP 4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.
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4.发明授权LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS 有权内酰胺化合物AS EP4受体的选择性激动剂FOR USE IN EP4介导的疾病和病症的治疗
公开(公告)号：EP2989098B1
公开(公告)日：2017-05-10
申请号：EP14729106.6
申请日：2014-03-14
发明人： BARRETT, Stephen, Douglas , COLOMBO, Joseph, Michael , GERMAIN, Bradlee, David , ENDRES, Gregory, William , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , CISKE, Fred, Lawrence , MAXEY, Kirk, M. , O'MALLEY, James, Paul , OWEN, Thomas, Allen
IPC分类号： C07D409/06 , C07D207/12 , C07D417/06 , C07D207/26
CPC分类号： C07D207/12 , C07D207/26 , C07D409/06 , C07D417/06
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5.发明授权DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS 有权用于EP4介导的骨关节病和病症的二氟内酰胺组合物
公开(公告)号：EP2874620B1
公开(公告)日：2016-10-12
申请号：EP13745254.6
申请日：2013-07-19
发明人： BARRETT, Stephen, Douglas , CISKE, Fred, Lawrence , COLOMBO, Joseph, Michael , ENDRES, Gregory, William , GERMAIN, Bradlee, David , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , OWEN, Thomas, Allen , O'MALLEY, James, Paul
IPC分类号： A61K31/4015 , A61K31/4025 , C07D409/06 , C07D207/26 , A61P19/10 , A61P19/08
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4025 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L27/58 , A61L2300/412 , A61L2300/604 , A61L2430/02 , C07D207/26 , C07D409/06
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6.发明公开DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS 有权DIFLUORLACTAMVERBINDUNGEN AS EP4受体选择性激动剂FOR USE IN EP4介导的疾病和病症的治疗
公开(公告)号：EP2875022A1
公开(公告)日：2015-05-27
申请号：EP13745744.6
申请日：2013-07-19
发明人： BARRETT, Stephen, Douglas , CISKE, Fred, Lawrence , COLOMBO, Joseph, Michael , ENDRES, Gregory, William , GERMAIN, Bradlee, David , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , MAXEY, Kirk, M.
IPC分类号： C07D403/12 , C07D207/20 , A61K31/4015 , A61K31/4025 , A61P27/02 , A61P27/06 , A61P25/02 , A61P17/14 , A61P19/10
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4025 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L27/58 , A61L2300/412 , A61L2300/604 , A61L2430/02 , C07D207/26 , C07D409/06
摘要： Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L
1 , L
2 , L
4 , R
1 , R
4 , R
5 , R
6 , and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.-
7.发明公开LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS 审中-公开内酰胺化合物作为EP4受体选择性激动剂用于治疗EP4介导的疾病和病症
公开(公告)号：EP3235817A1
公开(公告)日：2017-10-25
申请号：EP17169751.9
申请日：2014-03-14
发明人： BARRETT, Stephen, Douglas , COLOMBO, Joseph, Michael , GERMAIN, Bradlee, David , ENDRES, Gregory, William , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , CISKE, Fred, Lawrence , MAXEY, Kirk, M. , O'MALLEY, James, Paul , OWEN, Thomas, Allen
IPC分类号： C07D417/06 , C07D207/26 , A61K31/427 , A61P27/06
CPC分类号： C07D207/12 , C07D207/26 , C07D409/06 , C07D417/06
摘要： Disclosed herein are compounds of formula (I)
wherein L 1 , L 2 , L 3 , L 4 , R 1 , R 4 , R 5 , R 6 , and s are as defined in the specification. Compounds of formula (I) are EP 4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.摘要翻译： 本文公开了式（I）的化合物，其中L 1，L 2，L 3，L 4，R 1，R 4，R 5，R 6和s如说明书中所定义。 式（I）化合物是用于治疗青光眼，骨质疏松症，骨折，牙周骨丢失，整形外科植入物，脱发，神经性疼痛和相关病症的EP4激动剂。 还描述了治疗病症或病症的药物组合物和方法。
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公开(公告)号：EP3021879A2
公开(公告)日：2016-05-25
申请号：EP14750837.8
申请日：2014-07-18
发明人： BARRETT, Stephen, Douglas , COLOMBO, Joseph, Michael , GERMAIN, Bradlee, David , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , ENDRES, Gregory, William , CISKE, Fred, Lawrence , OWEN, Thomas, Allen , O'MALLEY, James, Paul
CPC分类号： A61L27/3608 , A61L27/24 , A61L27/365 , A61L27/425 , A61L27/54 , A61L2300/22 , A61L2430/02
摘要： The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.
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9.发明公开LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS 有权内酰胺化合物AS EP4受体的选择性激动剂FOR USE IN EP4介导的疾病和病症的治疗
公开(公告)号：EP2989098A2
公开(公告)日：2016-03-02
申请号：EP14729106.6
申请日：2014-03-14
发明人： BARRETT, Stephen, Douglas , COLOMBO, Joseph, Michael , GERMAIN, Bradlee, David , ENDRES, Gregory, William , KORNILOV, Andriy , KRAMER, James, Bernard , UZIEBLO, Adam , CISKE, Fred, Lawrence , MAXEY, Kirk, M. , O'MALLEY, James, Paul , OWEN, Thomas, Allen
IPC分类号： C07D417/06 , C07D207/26 , A61K31/427 , A61P27/06
CPC分类号： C07D207/12 , C07D207/26 , C07D409/06 , C07D417/06
摘要： Disclosed herein are compounds of formula (I) wherein L
1 , L
2 , L
3 , L
4 , R
1 , R
4 , R
5 , R
6 , and s are as defined in the specification. Compounds of formula (I) are EP
4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.
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