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公开(公告)号：EP1917042A2
公开(公告)日：2008-05-07
申请号：EP06824858.2
申请日：2006-08-24
IPC分类号： A61K49/00
CPC分类号： C12N15/1137 , A01K2267/0331 , C12N15/1138 , C12N2310/14 , C12Y202/01001 , C12Y207/01001 , C12Y207/01004 , C12Y401/02013
摘要： This invention relates to compositions, methods utilizing fructose and other monosaccharides for the diagnosis of cancer. Cancer cells have shown a higher level of fructose utilization as compared to glucose. Further, cancer cells have shown a preferential use of fructose for nucleic acid synthesis. The present invention takes advantage of these features and provides for fructose or fructose-based compositions for the diagnosis of cancer using imaging techniques such as positron emission tomography.
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公开(公告)号：EP1917042B1
公开(公告)日：2014-10-08
申请号：EP06824858.2
申请日：2006-08-24
IPC分类号： A61K51/00 , A61M36/14 , G01N33/574
CPC分类号： C12N15/1137 , A01K2267/0331 , C12N15/1138 , C12N2310/14 , C12Y202/01001 , C12Y207/01001 , C12Y207/01004 , C12Y401/02013
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3.发明公开METHODS OF MODULATING ANGIOGENESIS BY REGULATING THE EXPRESSION OF PITUITARY TUMOR TRANSFORMING GENE (PTTG) 审中-公开血管发生借规表达垂体肿瘤转化基因的调制方法（PTTG）
公开(公告)号：EP1280906A2
公开(公告)日：2003-02-05
申请号：EP01935430.7
申请日：2001-05-12
发明人： HEANEY, Anthony, P. , ISHIKAWA, Hiroki , YU, Run , HORWITZ, Gregory, A. , ZHANG, Xun , MELMED, Shlomo
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/82
摘要： Disclosed is a method of modulating angiogenesis in a tissue comprising mammalian cells, including cells of human origin, in vitro or in vivo. Also disclosed are a method of enhancing wound healing and/or tissue regeneration and a method of limiting scar formation.
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公开(公告)号：EP1917041A2
公开(公告)日：2008-05-07
申请号：EP06824852.5
申请日：2006-08-24
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A01K2267/0331 , C12N15/1138 , C12N2310/14 , C12Y202/01001 , C12Y207/01001 , C12Y207/01004 , C12Y401/02013
摘要： The methods and compositions of the invention are based on the preferential utilization of fructose by cancer cells. This invention relates to compositions, methods and kits utilizing fructose and other monosaccharides for the treatment of cancer. This invention also relates to methods and kits for using compositions to mimic or corrupt metabolic pathways of fructose and/or signal transduction pathways related to cancer cells for the treatment of cancer.
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5.发明公开USE OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR)-GAMMA LIGANDS AS A TREATMENT FOR PITUITARY TUMORS AND ASSOCIATED CONDITIONS, SUCH AS CUSHING'S SYNDROME 审中-公开过氧化物酶体增殖物激活受体（PPAR）-6配体的用于治疗垂体及相关疾病，如库欣综合征
公开(公告)号：EP1569643A2
公开(公告)日：2005-09-07
申请号：EP03737144.0
申请日：2003-06-04
IPC分类号： A61K31/44 , A61K31/41 , A61K31/425
CPC分类号： A61K31/426 , A61K31/4439
摘要： Disclosed is a method for treating a pituitary tumor in a mammal, employing the administration of a peroxisome proliferator activated receptor gamma ligand (also known as 'peroxisome proliferating-activator receptor gamma' or 'PPAR-Υ'). In some embodiments, the peroxisome proliferator activated receptor gamma ligand is a thiazolidinedione compound. Also disclosed are methods for preventing the formation of a pituitary tumor in a mammal and for preventing the recurrence of a pituitary tumor in a mammal. Further disclosed is a method for treating a mammal exhibiting one or more symptoms of Cushing's syndrome.
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6.发明公开TRANSGENIC CELLS TRANSFECTED WITH PITUITARY TUMOR TRANSFORMING GENE (PTTG) EXPRESSION VECTORS AND USES THEREFOR 审中-公开WITH PTTG（垂体肿瘤转化基因）的表达载体，THEREOF转染的细胞和用途
公开(公告)号：EP1546323A2
公开(公告)日：2005-06-29
申请号：EP03759698.8
申请日：2003-10-03
CPC分类号： C07K14/82 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/47 , C12N5/0617 , C12N2501/998 , C12N2510/00
摘要： Disclosed are transgenic cells trasfected with pituitary tumor transfer gene (PTTG)-containing expression vectors and uses therefor. The nucleic acids may be operatively linked to a vector, optionally provided with control and expression sequences and/or being carried by a host cell. In one embodiment, the host cell is a thyroid stimulating hormone (TSH)-sensitive cell transfected with an expression vector comprising a DNA segment encoding functional PTTG, wherein the cell overexpresses PTTG in response to TSH. Also disclosed is an in vitro cell model for the study of genetic regulation mediated by PTTG in a mammalian cell wherein PTTG expression can be modulated by exposing the cell to TSH or estrogen. In one embodiment, the cell model is used to study the effect of PTTG expression on NIS expression or to modulate NIS expression.
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