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公开(公告)号：EP3810752A1
公开(公告)日：2021-04-28
申请号：EP19800643.9
申请日：2019-05-07
发明人： SAREL STERN, Ina , YARKONI, Shai
IPC分类号： C12N5/0775 , A61K35/12 , A61K35/28
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2.发明公开SELECTIVE SURFACES FOR, AND METHODS OF, SELECTING A POPULATION OF STEM AND PROGENITOR CELLS, AND USES THEREOF 审中-公开选择茎和种子细胞群的选择性表面和方法及其用途
公开(公告)号：EP3303563A2
公开(公告)日：2018-04-11
申请号：EP16794072.5
申请日：2016-06-05
发明人： YARKONI, Shai , ALMOG, Tal
IPC分类号： C12N5/00 , C12N5/0783 , C12N5/078 , A61K35/12
摘要： The present invention discloses selective surfaces, wherein said selective surfaces comprise a biocompatible polymer comprising maleic anhydride molecules and an apoptosis inducing ligand bound to the maleic anhydride molecules. The invention also encompasses devices and kits comprising the selective surface and methods for its production. The selective surfaces may be used for functional selection of cell populations suitable for transplantation into human subjects.
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3.发明公开ACTIVATION OF HEMATOPOIETIC PROGENITORS BY PRETRANSPLANT EXPOSURE TO DEATH LIGANDS 审中-公开造血祖细胞BYPRÄTRANSPLANT-暂停对死亡配体活化
公开(公告)号：EP3054961A1
公开(公告)日：2016-08-17
申请号：EP14851547.1
申请日：2014-10-07
发明人： YARKONI, Shai
摘要： The present invention concerns methods for enhancing the engraftment and improving transplantation outcome of hematopoietic stem and progenitor cells by exposure of the cells to ligands of the TNF superfamily prior to transplantation. The invention also provides populations of hematopoietic stem and progenitor cells that were activated according to the method of the invention, for use in transplantation.
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公开(公告)号：EP2823040B1
公开(公告)日：2018-08-01
申请号：EP13758162.5
申请日：2013-03-05
发明人： YARKONI, Shai , ASKENASY, Nadir
IPC分类号： C12N5/0789 , B01D15/00 , A61K35/28
CPC分类号： C12N5/0081 , A61K35/12 , A61K35/28 , A61K35/30 , A61K35/51 , B01D15/00 , C12N2501/25 , C12N2501/599
摘要： The description discloses a device and a kit adapted for selection of cells that are resistant to receptor-mediated apoptosis and a method for using the device and kit. The device enables negative selection of mature immune cells which induce graft versus host disease (GvHD) out of a heterogeneous cell population which is introduced into the device. The device enables an efficient cell selection in simplified and cheaper setting by an off the shelf product—a solution that currently do not exist. The description further discloses uses for the device.
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公开(公告)号：EP2595637B1
公开(公告)日：2017-11-01
申请号：EP11751949.6
申请日：2011-07-21
发明人： ASKENASY, Nadir , YARKONI, Shai
CPC分类号： C12N5/0637 , A61K35/16 , A61K35/17 , A61K35/26 , A61K39/0008 , A61K39/001 , A61K2039/5158 , C12N5/0006 , C12N2501/48
摘要： An isolated immune regulatory cell having an exogenous cell death-inducing moiety attached to a surface thereof is disclosed herein. Additionally, a molecule comprising a cell death-inducing moiety heterologously attached to an immune regulatory cell-specific binding moiety is disclosed herein. Methods of generating and using same as well as pharmaceutical compositions comprising same are also disclosed.
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公开(公告)号：EP3303563B1
公开(公告)日：2020-05-27
申请号：EP16794072.5
申请日：2016-06-05
发明人： YARKONI, Shai , ALMOG, Tal
IPC分类号： C12N5/00 , C12N5/0783 , C12N5/078 , A61K35/12
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8.发明公开
公开(公告)号：EP3486315A1
公开(公告)日：2019-05-22
申请号：EP18181773.5
申请日：2013-03-05
发明人： YARKONI, Shai , ASKENASY, Nadir
IPC分类号： C12N5/0789 , B01D15/00 , A61K35/28
摘要： The present invention discloses a device and a kit adapted for selection of cells that are resistant to receptor-mediated apoptosis and a method for using the device and kit. The device enables negative selection of mature immune cells which induce graft versus host disease (GvHD) out of a heterogeneous cell population which is introduced into the device. The device enables an efficient cell selection in simplified and cheaper setting by an off the shelf product - a solution that currently do not exist. The present invention further discloses uses for the device.
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公开(公告)号：EP3353286A1
公开(公告)日：2018-08-01
申请号：EP16778893.4
申请日：2016-09-22
发明人： ALMOG, Tal , YARKONI, Shai
IPC分类号： C12N5/0775
CPC分类号： C12N5/06 , A61K35/12 , C12N5/0667 , C12N2501/25
摘要： Provided are methods for propagating mesenchymal stem cells (MSC), and particularly adipose derived stem cells, including incubating isolated cells obtained from a tissue or organ including MSC in a growth medium including an apoptosis inducing agent, under specified conditions. Further provided is an isolated cell population and kits for performing the methods.
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