公开(公告)号：EP3305889A1

公开(公告)日：2018-04-11

申请号：EP16802959.3

申请日：2016-04-26

申请人： National Institute of Advanced Industrial Science and Technology

发明人： KIDA, Yasuyuki ,  TAKAYAMA, Yuzo

IPC分类号： C12N5/00 ,  C12N1/00

CPC分类号： C12N5/0619 ,  C12N1/00 ,  C12N5/00 ,  C12N2501/155 ,  C12N2501/30 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/48 ,  C12N2506/03

摘要： Provided is a method for inducing differentiation of neural crest cells into neurons of the autonomic nervous system, the method including the step of culturing neural crest cells in the presence of at least one of a BMP signaling pathway activator, an SHH signaling pathway inhibitor, and a Wnt signaling pathway inhibitor.

摘要翻译： 本发明提供一种诱导神经嵴细胞分化为自主神经系统神经元的方法，该方法包括在存在BMP信号传导通路活化剂，SHH信号传导通路抑制剂和至少一种SHH信号通路抑制剂的情况下培养神经嵴细胞的步骤和 Wnt信号通路抑制剂。

公开(公告)号：EP3189828A4

公开(公告)日：2018-03-28

申请号：EP15857147

申请日：2015-11-09

申请人： EXOSTEMTECH CO LTD

发明人： CHO YONG WOO ,  CHOI JI SUK ,  YANG SEONG HYUN ,  LEE KYOUNG SOO ,  KIM EUN JI ,  YOON HWA IN ,  KIM JUN SUNG

IPC分类号： A61K8/98 ,  A61K8/02 ,  A61K8/04 ,  A61K9/06 ,  A61K35/12 ,  A61K35/28 ,  A61K35/44 ,  A61K35/51 ,  A61P17/00 ,  A61P17/02 ,  A61P17/18 ,  A61Q19/00

CPC分类号： C12N5/0653 ,  A61K8/02 ,  A61K8/0216 ,  A61K8/04 ,  A61K8/31 ,  A61K8/342 ,  A61K8/345 ,  A61K8/361 ,  A61K8/41 ,  A61K8/585 ,  A61K8/8105 ,  A61K8/86 ,  A61K8/925 ,  A61K8/98 ,  A61K8/981 ,  A61K35/28 ,  A61K35/35 ,  A61K35/51 ,  A61K2800/70 ,  A61K2800/74 ,  A61K2800/805 ,  A61P17/00 ,  A61P17/02 ,  A61P17/18 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C12N2500/90 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/231 ,  C12N2501/25 ,  C12N2501/33 ,  C12N2501/355 ,  C12N2501/48 ,  C12N2501/50 ,  C12N2501/734 ,  C12N2506/1384

摘要： The present invention relates to a pharmaceutical composition for inducing differentiation into adipocytes and/or regeneration of adipose tissues containing, as an active ingredient, an exosome derived from stem cells differentiating into adipocytes. The exosome shows an excellent expression rate of bioactive factors influencing the differentiation into adipocytes and has the effect of differentiating stem cells into adipocytes. Accordingly, the present invention can be applied as stem cell differentiation inducing agents, injectable preparations for tissue regeneration, fillers for cosmetic purposes, preparations for tissue engineering, etc. Further, the present invention relates to a cosmetic composition for skin whitening, wrinkle improvement and skin regeneration containing, as an active ingredient, an exosome derived from stem cells. The exosome contains genes, proteins, growth factors and the like associated with cell proliferation, differentiation and regeneration of stem cells; is a purified component which does not include antibiotics, serums or harmful factors of a culture solution; and is a cell-derived lipid carrier, and thus, the exosome can be applied to functional cosmetic compositions having skin whitening, wrinkle improvement and skin regeneration functions, and preparations for improving scar for cosmetic purposes, etc.

公开(公告)号：EP3152295A4

公开(公告)日：2017-11-15

申请号：EP15802756

申请日：2015-06-05

申请人： CEDARS-SINAI MEDICAL CENTER

发明人： SAREEN DHRUV ,  ORNELAS LOREN A ,  BARRETT ROBERT

IPC分类号： C12N5/00 ,  A01N63/00 ,  A61K35/12 ,  A61K35/17 ,  C12N5/074 ,  C12N15/00 ,  C12N15/86

CPC分类号： C12N5/0696 ,  A61K35/17 ,  A61K2035/124 ,  C12N15/00 ,  C12N15/86 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2501/235 ,  C12N2501/48 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/11

摘要： Described herein are methods and compositions related to generation of induced pluripotent stem cells (iPSCs). Improved techniques for establishing highly efficient, reproducible reprogramming using non-integrating episomal plasmid vectors, including generation of iPSCs from lymphoblastoid B-cells and lymphoblastoid B-cell lines. Such methods and compositions find use in regenerative medicine applications.

公开(公告)号：EP2708597B1

公开(公告)日：2017-11-15

申请号：EP12785650.8

申请日：2012-05-11

申请人： The University of Tokyo

发明人： ETO, Koji ,  NAKAUCHI, Hiromitsu ,  TAKAYAMA, Naoya ,  NAKAMURA, Sou

IPC分类号： C12N5/10 ,  A61K35/14 ,  A61P7/00 ,  C12N15/09

CPC分类号： C12N15/85 ,  A61K35/19 ,  C12N5/0644 ,  C12N2501/165 ,  C12N2501/48 ,  C12N2506/02

摘要： An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.

公开(公告)号：EP2595637B1

公开(公告)日：2017-11-01

申请号：EP11751949.6

申请日：2011-07-21

申请人： Cellect Biotherapeutics Ltd.

发明人： ASKENASY, Nadir ,  YARKONI, Shai

IPC分类号： A61K35/26 ,  A61P37/06 ,  A61P29/00 ,  A61K39/00 ,  C12N5/00 ,  C12N5/0783 ,  A61K35/17

CPC分类号： C12N5/0637 ,  A61K35/16 ,  A61K35/17 ,  A61K35/26 ,  A61K39/0008 ,  A61K39/001 ,  A61K2039/5158 ,  C12N5/0006 ,  C12N2501/48

摘要： An isolated immune regulatory cell having an exogenous cell death-inducing moiety attached to a surface thereof is disclosed herein. Additionally, a molecule comprising a cell death-inducing moiety heterologously attached to an immune regulatory cell-specific binding moiety is disclosed herein. Methods of generating and using same as well as pharmaceutical compositions comprising same are also disclosed.

公开(公告)号：EP3215166A1

公开(公告)日：2017-09-13

申请号：EP15855440.2

申请日：2015-10-15

申请人： The Trustees of the University of Pennsylvania

发明人： ZHAO, Yangbing ,  REN, Jiangtao ,  LIU, Xiaojun ,  JUNE, Carl H.

IPC分类号： A61K35/17

CPC分类号： C12N15/1138 ,  A61K35/17 ,  A61K35/26 ,  A61K39/0011 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61P35/00 ,  A61P37/06 ,  C12N15/85 ,  C12N2310/10 ,  C12N2310/20 ,  C12N2501/48 ,  C12N2501/515 ,  C12N2501/599 ,  C12N2501/998 ,  C12N2510/00

摘要： The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR α chain, TCR β chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

摘要翻译： 本发明涉及用于产生具有选自TCRα链，TCRβ链，β-2微球蛋白，HLA分子，CTLA-4的能下调内源性基因表达的核酸的修饰T细胞的组合物和方法 ，PD1和FAS，并且还包含编码包含对靶细胞上的表面抗原或编码嵌合抗原受体（CAR）的电穿孔核酸的亲和力的修饰T细胞受体（TCR）的核酸。 还包括用于过继治疗和治疗诸如自身免疫疾病的病症的包含修饰的T细胞的方法和药物组合物。

公开(公告)号：EP3049526A1

公开(公告)日：2016-08-03

申请号：EP14849368.7

申请日：2014-09-24

申请人： Medicenna Therapeutics, Inc.

发明人： MERCHANT, Fahar

IPC分类号： C12N15/62 ,  A61K47/48 ,  A61P19/04 ,  A61P35/00 ,  C07K14/54 ,  C07K14/82 ,  C07K19/00 ,  C12N15/24 ,  C07K14/715

CPC分类号： C07K14/5406 ,  A61K38/00 ,  A61K38/1761 ,  A61K38/193 ,  A61K38/2026 ,  C07K14/4747 ,  C07K2319/00 ,  C12N5/0602 ,  C12N5/0636 ,  C12N15/63 ,  C12N2501/48

摘要： The present invention relates to interleukin-4 receptor binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that include an interleukin-4 receptor binding protein moiety joined to a pro-apoptotic Bcl-2 family member protein moiety.

公开(公告)号：EP2970885A1

公开(公告)日：2016-01-20

申请号：EP14779483.8

申请日：2014-03-11

申请人： Taiga Biotechnologies, Inc.

发明人： TURNER, Brian Curtis ,  REFAELI, Yosef ,  BIRD, Gregory A.

IPC分类号： C12N5/00 ,  C12N5/071

CPC分类号： C12N5/0647 ,  C07K14/4747 ,  C07K14/82 ,  C07K2319/00 ,  C12N7/00 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2501/26 ,  C12N2501/48 ,  C12N2501/606 ,  C12N2501/998 ,  C12N2510/04 ,  C12N2740/15033

摘要： Disclosed are methods for manipulating and expanding stem cell populations, including adult stem cells, the cells produced by such methods, and various protein constructs related thereto.

公开(公告)号：EP2956164A1

公开(公告)日：2015-12-23

申请号：EP14751889.8

申请日：2014-02-14

申请人： Immunocellular Therapeutics Ltd. ,  Cedars-Sinai Medical Center

发明人： YU, John, S. ,  ZHENHUA, Li ,  ORSULIC, Sandra ,  KARLAN, Beth, Y. ,  BENDER, James, G.

IPC分类号： A61K39/00 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K31/675 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/585 ,  A61K2039/70 ,  C12N5/0639 ,  C12N2501/11 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/25 ,  C12N2501/48 ,  C12N2501/50 ,  C12N2501/599 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2506/115

摘要： Compositions of multipeptide vaccines including tumor associated antigens, compositions of antigen presenting cell (e.g., dendritic cell) based vaccines presenting epitopes from tumor associated antigens, and methods of making same, are provided herein. Also, disclosed are methods for treating ovarian cancers using such vaccines.

公开(公告)号：EP2331678B1

公开(公告)日：2015-09-30

申请号：EP09763701.1

申请日：2009-06-12

申请人： Janssen Biotech, Inc.

发明人： DORAI, Haimanti ,  KYUNG, Yun, Seung

IPC分类号： C12N5/10 ,  C12N5/07

CPC分类号： C12N5/0018 ,  C12N2500/34 ,  C12N2501/48 ,  C12N2510/00 ,  C12N2510/02