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公开(公告)号：EP2021314A1
公开(公告)日：2009-02-11
申请号：EP07760976.6
申请日：2007-04-20
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , HO, Chih Yung , ZHANG, Yan
IPC分类号： C07C59/68 , C07C229/42 , A61K31/192 , A61K31/196 , A61P25/28
CPC分类号： C07C229/42 , C07C59/68
摘要： The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity, wherein A is O, NH, S; X is a bond or a group -CR5R6 Υ is a carboxy group -C(O)OH or a substituted or unsubstituted tetrazole group..
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公开(公告)号：EP2016039A1
公开(公告)日：2009-01-21
申请号：EP07760900.6
申请日：2007-04-19
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard, John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , ZHANG, Yan , HO, Chih Yung
IPC分类号： C07C51/09 , C07C57/38 , C07C57/58 , C07C59/64 , C07D257/04 , A61K31/192 , A61P25/28
CPC分类号： C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要： The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
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公开(公告)号：EP1805129B1
公开(公告)日：2009-03-18
申请号：EP05799330.5
申请日：2005-10-21
申请人： Cellzome Limited
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard, John , SUNOSE, Mihiro , HERNANDEZ-Perni, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja
IPC分类号： C07C59/68 , C07C59/72 , C07D295/22 , C07D261/08 , C07D309/06 , C07D295/18 , C07C235/34 , C07C311/17 , C07C317/22 , A61P25/28 , A61K31/192
CPC分类号： C07C59/68 , C07C59/72 , C07C233/54 , C07C235/42 , C07C311/29 , C07C317/22 , C07C317/46 , C07C2601/02 , C07C2601/14 , C07D261/08 , C07D295/192 , C07D295/26 , C07D309/06
摘要： The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of Ϝ-secretase activity.
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公开(公告)号：EP2021314B1
公开(公告)日：2013-01-23
申请号：EP07760976.6
申请日：2007-04-20
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , HO, Chih Yung , ZHANG, Yan
IPC分类号： C07C59/68 , C07C229/42 , A61K31/192 , A61K31/196 , A61P25/28
CPC分类号： C07C229/42 , C07C59/68
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公开(公告)号：EP2491039A1
公开(公告)日：2012-08-29
申请号：EP10775748.6
申请日：2010-10-19
申请人： Cellzome Limited
发明人： RAMSDEN, Nigel , HARRISON, Richard John , OXENFORD, Sally , BELL, Kathryn , PITON, Nelly , DAGOSTIN, Claudio , BOUSSARD, Cyrille , RATCLIFFE, Andrew
IPC分类号： C07D487/04 , A61K31/505 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) wherein X
1 to X
5 , Y, Z
1 to Z
3 , and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.-
6.发明公开HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS SELECTIVE JAK INHIBITORS 审中-公开杂环PYRAZOLPYRIMIDIN物作为选择性JAK抑制剂
公开(公告)号：EP2606050A2
公开(公告)日：2013-06-26
申请号：EP11744008.1
申请日：2011-08-12
申请人： Cellzome Limited
发明人： BELL, Kathryn , PITON, Nelly , DAGOSTIN, Claudio , BOUSSARD, Cyrille , RATCLIFFE, Andrew , RAMSDEN, Nigel
IPC分类号： C07D487/04 , A61K31/505 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein X
1 to X
5 , Y, Z
1 to Z
3 , and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.-
公开(公告)号：EP2016039B1
公开(公告)日：2012-08-01
申请号：EP07760900.6
申请日：2007-04-19
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard, John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , ZHANG, Yan , HO, Chih Yung
IPC分类号： C07C51/09 , C07C57/38 , C07C57/58 , C07C59/64 , C07D257/04 , A61K31/192 , A61P25/28
CPC分类号： C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要： The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
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