公开(公告)号：EP2513083B1

公开(公告)日：2016-04-06

申请号：EP10790539.0

申请日：2010-12-07

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Universite Rennes 1 ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Montpellier 2 Sciences et Techniques

发明人： BREVET, David ,  RAEHM, Laurence ,  BLANCHARD-DESCE, Mireille ,  MONGIN, Olivier ,  GARY-BOBO-SABLE-TEYCHENE, Magali ,  GARCIA, Marcel ,  MORERE, Alain ,  DURAND, Jean-Olivier

IPC分类号： C07D333/16 ,  C07D333/20 ,  C07D495/04 ,  A61K41/00 ,  A61K47/48 ,  A61P35/00

CPC分类号： C07F7/1836 ,  B82Y30/00 ,  C07D333/16 ,  C07D333/20 ,  C07D409/10 ,  C07D495/04 ,  C07F7/0801 ,  C07F7/10 ,  C07H23/00

公开(公告)号：EP2513083A1

公开(公告)日：2012-10-24

申请号：EP10790539.0

申请日：2010-12-07

申请人： CNRS Centre National de la Recherche Scientifique ,  Universite Rennes 1 ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Montpellier 2 Sciences et Techniques

发明人： BREVET, David ,  RAEHM, Laurence ,  BLANCHARD-DESCE, Mireille ,  MONGIN, Olivier ,  GARY-BOBO-SABLE-TEYCHENE, Magali ,  GARCIA, Marcel ,  MORERE, Alain ,  DURAND, Jean-Olivier

IPC分类号： C07D333/16 ,  C07D333/20 ,  C07D495/04 ,  A61K41/00 ,  A61K47/48 ,  A61P35/00

CPC分类号： C07F7/1836 ,  B82Y30/00 ,  C07D333/16 ,  C07D333/20 ,  C07D409/10 ,  C07D495/04 ,  C07F7/0801 ,  C07F7/10 ,  C07H23/00

摘要： The invention relates to compounds of formula (I) : the groups A and B represent independently from each other -CH=CH-, or -C≡C-, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y
1 and Y
2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z
1 , Z
2 , Z
3 , and Z
4 can represent independently from each other a chemically reactive group W, such as OH, NH
2 , SH, the groups Z
5 and Z
6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.