公开(公告)号：EP2513083A1

公开(公告)日：2012-10-24

申请号：EP10790539.0

申请日：2010-12-07

申请人： CNRS Centre National de la Recherche Scientifique ,  Universite Rennes 1 ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Montpellier 2 Sciences et Techniques

发明人： BREVET, David ,  RAEHM, Laurence ,  BLANCHARD-DESCE, Mireille ,  MONGIN, Olivier ,  GARY-BOBO-SABLE-TEYCHENE, Magali ,  GARCIA, Marcel ,  MORERE, Alain ,  DURAND, Jean-Olivier

IPC分类号： C07D333/16 ,  C07D333/20 ,  C07D495/04 ,  A61K41/00 ,  A61K47/48 ,  A61P35/00

CPC分类号： C07F7/1836 ,  B82Y30/00 ,  C07D333/16 ,  C07D333/20 ,  C07D409/10 ,  C07D495/04 ,  C07F7/0801 ,  C07F7/10 ,  C07H23/00

摘要： The invention relates to compounds of formula (I) : the groups A and B represent independently from each other -CH=CH-, or -C≡C-, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y
1 and Y
2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z
1 , Z
2 , Z
3 , and Z
4 can represent independently from each other a chemically reactive group W, such as OH, NH
2 , SH, the groups Z
5 and Z
6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

公开(公告)号：EP2513083B1

公开(公告)日：2016-04-06

申请号：EP10790539.0

申请日：2010-12-07

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Universite Rennes 1 ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Montpellier 2 Sciences et Techniques

发明人： BREVET, David ,  RAEHM, Laurence ,  BLANCHARD-DESCE, Mireille ,  MONGIN, Olivier ,  GARY-BOBO-SABLE-TEYCHENE, Magali ,  GARCIA, Marcel ,  MORERE, Alain ,  DURAND, Jean-Olivier

IPC分类号： C07D333/16 ,  C07D333/20 ,  C07D495/04 ,  A61K41/00 ,  A61K47/48 ,  A61P35/00

CPC分类号： C07F7/1836 ,  B82Y30/00 ,  C07D333/16 ,  C07D333/20 ,  C07D409/10 ,  C07D495/04 ,  C07F7/0801 ,  C07F7/10 ,  C07H23/00

公开(公告)号：EP2831081A1

公开(公告)日：2015-02-04

申请号：EP13716977.7

申请日：2013-03-26

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université Montpellier 2, Sciences et Techniques ,  The Regents of the University of California ,  Ecole Nationale Supérieure de Chimie de Montpellier

发明人： CUNIN, Frédérique ,  DURAND, Jean-Olivier ,  SAILOR, Michael J. ,  GARCIA, Marcel ,  SECRET, Emilie ,  GARY-BOBO, Magali ,  MAYNADIER, Marie ,  MORERE, Alain

IPC分类号： C07D487/22 ,  A61K31/409 ,  A61K41/00 ,  H01L51/00

CPC分类号： A61K41/0071 ,  A61K31/28 ,  A61K31/315 ,  A61K31/409 ,  A61K41/008 ,  A61N5/062 ,  C09B47/00 ,  Y10T428/2982

摘要： The invention relates to nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by means of photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by means of excitation in the near-infrared region (> 600 nm) in monophotonic and biphotonic modes. According to the invention, in formula (I), (AA) is a porous silicon nanoparticle.

公开(公告)号：EP2831081B1

公开(公告)日：2016-10-19

申请号：EP13716977.7

申请日：2013-03-26

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université Montpellier 2, Sciences et Techniques ,  The Regents of the University of California ,  Ecole Nationale Supérieure de Chimie de Montpellier

发明人： CUNIN, Frédérique ,  DURAND, Jean-Olivier ,  SAILOR, Michael J. ,  GARCIA, Marcel ,  SECRET, Emilie ,  GARY-BOBO, Magali ,  MAYNADIER, Marie ,  MORERE, Alain

IPC分类号： C07D487/22 ,  C09K11/59 ,  A61K41/00 ,  A61K31/409 ,  B82Y5/00 ,  A61P35/00

CPC分类号： A61K41/0071 ,  A61K31/28 ,  A61K31/315 ,  A61K31/409 ,  A61K41/008 ,  A61N5/062 ,  C09B47/00 ,  Y10T428/2982