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1.发明授权BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS 有权生物光子光敏剂纳米粒子与它和它们作为药物的用途
公开(公告)号：EP2513083B1
公开(公告)日：2016-04-06
申请号：EP10790539.0
申请日：2010-12-07
申请人： Centre National de la Recherche Scientifique (CNRS) , Universite Rennes 1 , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Montpellier 2 Sciences et Techniques
发明人： BREVET, David , RAEHM, Laurence , BLANCHARD-DESCE, Mireille , MONGIN, Olivier , GARY-BOBO-SABLE-TEYCHENE, Magali , GARCIA, Marcel , MORERE, Alain , DURAND, Jean-Olivier
IPC分类号： C07D333/16 , C07D333/20 , C07D495/04 , A61K41/00 , A61K47/48 , A61P35/00
CPC分类号： C07F7/1836 , B82Y30/00 , C07D333/16 , C07D333/20 , C07D409/10 , C07D495/04 , C07F7/0801 , C07F7/10 , C07H23/00
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2.发明公开BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS 有权生物光子光敏剂纳米粒子与它和它们作为药物的用途
公开(公告)号：EP2513083A1
公开(公告)日：2012-10-24
申请号：EP10790539.0
申请日：2010-12-07
申请人： CNRS Centre National de la Recherche Scientifique , Universite Rennes 1 , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Montpellier 2 Sciences et Techniques
发明人： BREVET, David , RAEHM, Laurence , BLANCHARD-DESCE, Mireille , MONGIN, Olivier , GARY-BOBO-SABLE-TEYCHENE, Magali , GARCIA, Marcel , MORERE, Alain , DURAND, Jean-Olivier
IPC分类号： C07D333/16 , C07D333/20 , C07D495/04 , A61K41/00 , A61K47/48 , A61P35/00
CPC分类号： C07F7/1836 , B82Y30/00 , C07D333/16 , C07D333/20 , C07D409/10 , C07D495/04 , C07F7/0801 , C07F7/10 , C07H23/00
摘要： The invention relates to compounds of formula (I) : the groups A and B represent independently from each other -CH=CH-, or -C≡C-, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y
1 and Y
2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z
1 , Z
2 , Z
3 , and Z
4 can represent independently from each other a chemically reactive group W, such as OH, NH
2 , SH, the groups Z
5 and Z
6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.-
3.发明公开NANOPARTICULES DE SILICIUM POREUX FONCTIONNALISEES ET LEURS UTILISATIONS EN THERAPIE PHOTODYNAMIQUE 有权功能化的多孔硅纳米颗粒及其用途在光动力治疗
公开(公告)号：EP2831081A1
公开(公告)日：2015-02-04
申请号：EP13716977.7
申请日：2013-03-26
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Montpellier 2, Sciences et Techniques , The Regents of the University of California , Ecole Nationale Supérieure de Chimie de Montpellier
发明人： CUNIN, Frédérique , DURAND, Jean-Olivier , SAILOR, Michael J. , GARCIA, Marcel , SECRET, Emilie , GARY-BOBO, Magali , MAYNADIER, Marie , MORERE, Alain
IPC分类号： C07D487/22 , A61K31/409 , A61K41/00 , H01L51/00
CPC分类号： A61K41/0071 , A61K31/28 , A61K31/315 , A61K31/409 , A61K41/008 , A61N5/062 , C09B47/00 , Y10T428/2982
摘要： The invention relates to nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by means of photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by means of excitation in the near-infrared region (> 600 nm) in monophotonic and biphotonic modes. According to the invention, in formula (I), (AA) is a porous silicon nanoparticle.
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4.发明授权NANOPARTICULES DE SILICIUM POREUX FONCTIONNALISEES ET LEURS UTILISATIONS EN THERAPIE PHOTODYNAMIQUE 有权FERKTIONALISIERTEPORÖSESILICIUMNANOPARTIKEL UND VERWENDUNG DAVON IN DER PHOTODYNAMISCHEN THERAPIE
公开(公告)号：EP2831081B1
公开(公告)日：2016-10-19
申请号：EP13716977.7
申请日：2013-03-26
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Montpellier 2, Sciences et Techniques , The Regents of the University of California , Ecole Nationale Supérieure de Chimie de Montpellier
发明人： CUNIN, Frédérique , DURAND, Jean-Olivier , SAILOR, Michael J. , GARCIA, Marcel , SECRET, Emilie , GARY-BOBO, Magali , MAYNADIER, Marie , MORERE, Alain
IPC分类号： C07D487/22 , C09K11/59 , A61K41/00 , A61K31/409 , B82Y5/00 , A61P35/00
CPC分类号： A61K41/0071 , A61K31/28 , A61K31/315 , A61K31/409 , A61K41/008 , A61N5/062 , C09B47/00 , Y10T428/2982
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5.发明公开
公开(公告)号：EP3405217A1
公开(公告)日：2018-11-28
申请号：EP17703928.6
申请日：2017-01-18
发明人： DURAND, Jean-Olivier , MAURIELLO JIMENEZ, Chiara , RICHETER, Sébastien , RAEHM, Laurence , GARY-BOBO, Magali , GARCIA, Marcel , MAYNADIER, Marie
摘要： The present invention relates to mesoporous organosilica nanoparticles, the production method thereof and the uses of same in treatment involving photodynamic therapy or in imaging.
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">6.发明授权DISPOSITIF DE PRESENTATION DE POLYPEPTIDES, UTILISABLE COMME "PUCE" POUR LA DETECTION MINIATURISEE DE MOLECULES. 有权DEVICE FORPOLYPEPTIDPRÄSENTATION，用作传感器芯片检测分子的小型化
公开(公告)号：EP1390751B1
公开(公告)日：2011-11-30
申请号：EP02740818.6
申请日：2002-05-27
发明人： MELNYK, Oleg , GRAS-MASSE, Hélène , OLIVIER, Christophe , DURAND, Jean-Olivier , AURIAULT, Claude , DUBURCQ, Xavier , BOUZIDI, Ahmed , GARCIA, Jean-Michel , EL-MAHDI, Ouafâa
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/54353
摘要： The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .
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7.发明授权
公开(公告)号：EP3405217B1
公开(公告)日：2020-06-03
申请号：EP17703928.6
申请日：2017-01-18
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