专利检索 ap:("Centre National de la Recherche Scientifique (CNRS)" OR "Universite de Montpellier 1" OR "Etablissement Français du Sang" OR "Université Claude Bernard Lyon 1") AND inv:"CANTALOUBE, Jean-François" 第 1 页

1.

发明公开
COMPOSÉS THIOL ET LEUR UTILISATION POUR LA SYNTHÈSE D'OLIGONUCLÉOTIDES MODIFIÉS 有权
标题翻译：硫醇化合物及其用于修饰的寡核苷酸的制造

公开(公告)号：EP2834253A1

公开(公告)日：2015-02-11

申请号：EP13713922.6

申请日：2013-04-04

申请人： Centre National de la Recherche Scientifique (CNRS) , Universite de Montpellier 1 , Etablissement Français du Sang , Université Claude Bernard Lyon 1

发明人： MORVAN, François , MEYER, Albert , VASSEUR, Jean-Jacques , MAYEN, Julie , CHAIX, Carole , FARRE, Carole , FOURNIER-WIRTH, Chantal , CANTALOUBE, Jean-François , LEREAU, Myriam

IPC分类号： C07F9/44

CPC分类号： C07H21/04 , C07C323/52 , C07F9/2408 , C08F257/02 , C12N15/11

摘要： The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

2.

发明公开
OLIGONUCLEOTIDES MODIFIES COMPENANT DES FONCTIONS THIOL ET LEUR UTILISATION POUR LA DETECTION D'ACIDES NUCLEIQUES 有权
标题翻译：修饰的寡核苷酸与巯基功能及其使用对于核酸的检测

公开(公告)号：EP2859008A1

公开(公告)日：2015-04-15

申请号：EP13716756.5

申请日：2013-04-04

申请人： Etablissement Français Du Sang (EFS) , Centre National de la Recherche Scientifique (CNRS) , Universite de Montpellier 1 , Université Claude Bernard Lyon 1

发明人： FOURNIER-WIRTH, Chantal , LEREAU, Myriam , CANTALOUBE, Jean-François , VASSEUR, Jean-Jacques , MORVAN, François , MEYER, Albert , MAYEN, Julie , CHAIX, Carole , FARRE, Carole

IPC分类号： C07H21/00 , C07H21/04 , G01N33/50

CPC分类号： C07H21/00 , C07H21/04 , C12Q1/707

摘要： The present invention concerns a modified oligonucleotide having two or a plurality of thiol functions, capable of being immobilised on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or one carbon-carbon triple bond or halogen acetamide functions, preferably maleimide or acrylamide functions. The invention also concerns a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridisation between a modified oligonucleotide and an amplified target nucleic acid from the biological sample. The invention more specifically concerns a method for detecting genotyping or sequencing of a pathogenic organism, preferably a virus.

摘要翻译： 本发明涉及一种具有两个或更多个巯基的功能，它可以在金表面或上的接枝表面上固定化的修饰寡核苷酸，特别是表面，其包括至少一个碳 - 碳双键或碳 - 碳三键或卤代乙酰胺功能，优选马来酰亚胺或丙烯酰胺功能。因此本发明涉及一种用于生物样品包含修饰寡核苷酸和靶核酸从生物样品扩增之间检测杂交的步骤中检测核酸的方法。本发明更具体地涉及一种用于检测，基因分型或测序的病原生物，优选的病毒。