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公开(公告)号:EP3960195A1
公开(公告)日:2022-03-02
申请号:EP21189549.5
申请日:2016-09-23
申请人: Centre national de la recherche scientifique , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , College de France , SORBONNE UNIVERSITE
发明人: PROCHIANTZ, Alain
摘要: The present invention relates to the use of a homeoprotein or a recombinant vector encoding said protein for treating or preventing DNA damage and/or cellular aging. In particular, the invention concerns the use of Engrailed for the treatment of amyotrophic lateral sclerosis disease.
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公开(公告)号:EP3807295A1
公开(公告)日:2021-04-21
申请号:EP19729797.1
申请日:2019-06-17
申请人: College de France , Ecole Normale Supérieure , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SORBONNE UNIVERSITE , Centre National de la Recherche Scientifique (CNRS)
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公开(公告)号:EP3016661B1
公开(公告)日:2018-10-10
申请号:EP14761691.6
申请日:2014-07-04
申请人: Centre National de la Recherche Scientifique , College de France , Institut National de la Santé et de la Recherche Médicale (INSERM)
IPC分类号: A61K31/7088 , C12N15/63 , A61K39/395 , A61K39/00 , C07K16/18
CPC分类号: C07K16/18 , A61K39/0007 , A61K48/00 , A61K2039/54 , C07K2317/622 , C07K2317/76 , C12N15/113 , C12N2310/14 , C12N2750/14143
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4.INHIBITION DE LA SYNTHÈSE DE LA PROTÉINE BETA-APP OU DE L'ACTIVITÉ DU PEPTIDE A-BETA DANS LES PLEXUS CHOROÏDES 审中-公开
标题翻译: BETA-APP的合成或在脉络丛中A-β肽的活性的抑制公开(公告)号:EP3016661A1
公开(公告)日:2016-05-11
申请号:EP14761691.6
申请日:2014-07-04
申请人: Centre National de la Recherche Scientifique , College de France , Institut National de la Santé et de la Recherche Médicale (INSERM)
IPC分类号: A61K31/7088 , C12N15/63 , A61K39/395 , A61K39/00 , C07K16/18
CPC分类号: C07K16/18 , A61K39/0007 , A61K48/00 , A61K2039/54 , C07K2317/622 , C07K2317/76 , C12N15/113 , C12N2310/14 , C12N2750/14143
摘要: The invention relates to the treatment of neurodegenerative diseases, in particular Alzheimer's disease, by inhibition of the synthesis of βΑΡΡ or of the activity of the Aβ peptide in the choroid plexus.
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5.UTILISATION D'UN INHIBITEUR DE TRANSCRIPTASE INVERSE DANS LA PREVENTION ET LE TRAITEMENT DES MALADIES DEGENERATIVES 审中-公开
标题翻译: 利用联合国禁止转录酶反转染色体防止染色体畸变的方法公开(公告)号:EP3212200A1
公开(公告)日:2017-09-06
申请号:EP15798211.7
申请日:2015-10-30
申请人: Centre National de la Recherche Scientifique , College de France , INSERM - Institut National de la Santé et de la Recherche Médicale , Université Pierre et Marie Curie
发明人: PROCHIANTZ, Alain , FUCHS, Julia , JOSHI, Rajiv , BLAUDIN DE THE, François Xavier , REKAIK, Hocine , MASSIANI-BEAUDOIN, Olivia
IPC分类号: A61K31/7072 , A61P25/28
CPC分类号: C12N15/113 , A61K31/7072 , C12N15/63 , C12N2740/00011 , C12Q1/25 , C12Q1/68
摘要: The invention relates to the use of a reverse-transcriptase inhibitor in the prevention or treatment of a degenerative disease.
摘要翻译: 本发明涉及逆转录酶抑制剂在预防或治疗退行性疾病中的用途。
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公开(公告)号:EP3352777A1
公开(公告)日:2018-08-01
申请号:EP16777596.4
申请日:2016-09-23
申请人: Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale (INSERM) , College de France , Sorbonne Université
发明人: PROCHIANTZ, Alain
CPC分类号: A61K38/17
摘要: The present invention relates to the use of a homeoprotein or a recombinant vector encoding said protein for treating or preventing DNA damage and/or cellular aging. In particular, the invention concerns the use of Engrailed for the treatment of Parkinson disease.
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7.UTILISATION DE LA PROTEINE A HOMEODOMAINE ENGRAILED COMME ANXIOLYTIQUE 有权
标题翻译: 蛋白质ENGRAILED同源域为抗焦虑剂使用公开(公告)号:EP1993587B1
公开(公告)日:2011-10-19
申请号:EP07731062.1
申请日:2007-02-28
CPC分类号: A61K38/1709
摘要: The present invention relates to the use of an Engrailed transcription factor for producing a medicament for anxiolytic purposes.
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8.PEPTIDES UTILISABLES COMME VECTEURS POUR L'ADRESSAGE INTRACELLULAIRE DE MOLECULES ACTIVES 失效
标题翻译: 肽向量细胞内活性分子的寻址公开(公告)号:EP0797589A1
公开(公告)日:1997-10-01
申请号:EP96933490.0
申请日:1996-10-04
CPC分类号: C07K14/43581 , A61K47/62 , C12N15/87
摘要: The invention relates to a peptide having the sequence (I) or (Ia), wherein X1, X2, X3, X4, X5, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16 each represent an α-aminoacid, X6 representing tryptophane. Said peptide comprises between 6 and 10 hydrophobic aminoacids. The invention also relates to the use of said peptide for introducing into living cells an active molecule acting on cellular functions.
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9.PEPTIDES MODULATEURS DE L'ACTIVITE DU FACTEUR DE TRANSCRIPTION ENGRAILED 有权
标题翻译: 肽类转录因子活性来调节ENGRAILED公开(公告)号:EP1625152B1
公开(公告)日:2006-09-13
申请号:EP04742777.8
申请日:2004-05-19
申请人: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Ecole Normale Superieure , Universite Paris 13
CPC分类号: C07K7/08 , A61K38/00 , C07K19/00 , C07K2319/00
摘要: The invention relates to peptides which can become fixed to the engrailed transcription factor and which can modulate the activity thereof.
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10.PEPTIDES UTILISABLES COMME VECTEURS POUR L'ADRESSAGE INTRACELLULAIRE DE MOLECULES ACTIVES 失效
标题翻译: 肽向量细胞内活性分子的寻址公开(公告)号:EP0797589B1
公开(公告)日:2005-12-28
申请号:EP96933490.3
申请日:1996-10-04
IPC分类号: C07K14/47
CPC分类号: C07K14/43581 , A61K47/62 , C12N15/87
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