公开(公告)号：EP4442698A1

公开(公告)日：2024-10-09

申请号：EP22914735.0

申请日：2022-12-27

申请人： Chengdu Origen Biotechnology Co., Ltd.

发明人： KE, Xiao ,  ZHENG, Qiang ,  LUO, Shuang ,  JIANG, Hao

IPC分类号： C07K14/015 ,  C12N7/00 ,  C12N15/35 ,  C12N15/864 ,  A61K48/00 ,  A61K38/00 ,  A61K35/76 ,  A61P27/02 ,  A61P19/02

CPC分类号： A61K35/76 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P27/06 ,  A61P29/00 ,  A61P27/02 ,  C07K14/015 ,  C12N7/00 ,  C12N15/864

摘要： The present invention relates to a modified adeno-associated virus (AAV) capsid protein and use thereof; said capsid protein comprises substitution of approximately 5-14 amino acids with respect to a parent AAV capsid protein; furthermore, the AAV containing the modified capsid protein has increased infectiousness with respect to a target tissue or target cell (e.g. retinal cell) in comparison with an AAV comprising an unmodified parent AAV capsid protein.