公开(公告)号：EP3533796A1

公开(公告)日：2019-09-04

申请号：EP17863410.1

申请日：2017-10-27

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Centaurus BioPharma Co., Ltd. ,  Lianyungang Runzhong Pharmaceutical Co., Ltd.

发明人： ZHU, Li ,  HU, Yuandong ,  WU, Wei ,  DAI, Liguang ,  DUAN, Xiaowei ,  YANG, Yanqing ,  SUN, Yinghui ,  HAN, Yongxin ,  PENG, Yong ,  KONG, Fansheng ,  LUO, Hong ,  YANG, Ling ,  XU, Hongjiang ,  GUO, Meng ,  ZHONG, Zhaobai ,  WANG, Shanchun

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377

摘要： Provided is an amino pyrazolopyrimidine compound as represented by the following structural formula used as a neurotrophic factor tyrosine kinase receptor inhibitor. The compound can inhibit the activity of Trk kinase and can treat diseases mediated by a Trk tyrosine kinase receptor in mammals.

公开(公告)号：EP3412669A1

公开(公告)日：2018-12-12

申请号：EP17747001.0

申请日：2017-02-04

申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd ,  Centaurus BioPharma Co., Ltd. ,  Lianyungang Runzhong Pharmaceutical Co., Ltd.

发明人： LI, Jijun ,  WU, Wei ,  ZHU, Yan ,  WANG, Huting ,  ZHAO, Lijia ,  HE, Weinan ,  SUN, Yinghui ,  PENG, Yong ,  HAN, Yongxin

IPC分类号： C07D471/14 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/437 ,  A61P35/00 ,  A61P31/12 ,  A61P25/28 ,  A61P29/00 ,  A61P9/10

CPC分类号： A61K31/437 ,  A61K31/4375 ,  C07D471/04 ,  C07D471/14

摘要： The present applicationpresent application relates to a compound represented by Formula (III) or a pharmaceutically acceptable salt, solvent compound, active metabolite, crystal polymorph, ester, isomer, or prodrug thereof. The application further provides a pharmaceutical composition comprising the compound represented by Formula (III) and a use thereof for preparing a bromodomain inhibitor for preventing or treating various diseases, such as inflammation and cancer, related to the bromodomain.

公开(公告)号：EP2661437A1

公开(公告)日：2013-11-13

申请号：EP12732345.9

申请日：2012-01-07

申请人： Centaurus Biopharma Co., Ltd.

发明人： XIAO, Dengming ,  CHENG,Liang ,  LIU, Xijie ,  HU, Yuandong ,  XU, Xinhe ,  LIU, Zhihua ,  ZHANG, Lipeng ,  WU, Wei ,  WANG, Shulong ,  SHEN, Yu ,  LI, Gen ,  WANG, Yin ,  ZHAO, Sheng ,  LI, Chonglong ,  TANG, Jia ,  YU, Honghao

IPC分类号： C07D487/04 ,  A61K31/505 ,  A61P35/00 ,  A61P29/00 ,  A61P31/00 ,  A61P37/02

CPC分类号： C07D487/04 ,  A61K31/4523 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D493/12

摘要： The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.