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公开(公告)号：EP3235819A1
公开(公告)日：2017-10-25
申请号：EP15869312.7
申请日：2015-12-15
申请人： Centaurus BioPharma Co., Ltd. , Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： ZHU, Li , XIAO, Dengming , HU, Yuandong , DAI, Liguang , DUAN, Xiaowei , SUN, Yinghui , PENG, Yong , KONG, Fansheng , LUO, Hong , HAN, Yongxin , YANG, Ling , WANG, Shanchun
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P35/00
摘要： The present application relates to the field of pharmaceutical chemistry, and in particular, to a pyrrolopyrimidine compound represented by general formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for preparing the pyrrolopyrimidine compound represented by general formula (I), pharmaceutical compositions and an application of the pyrrolopyrimidine compound in treating diseases mediated by Janus Kinase.
摘要翻译： 本申请涉及药物化学领域，特别涉及通式（I）所示的吡咯并嘧啶化合物，其立体异构体或其药学上可接受的盐。 本发明还涉及通式（I）代表的吡咯并嘧啶化合物的制备方法，药物组合物和吡咯并嘧啶化合物在治疗由Janus激酶介导的疾病中的用途。
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2.发明公开
公开(公告)号：EP3533796A1
公开(公告)日：2019-09-04
申请号：EP17863410.1
申请日：2017-10-27
申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： ZHU, Li , HU, Yuandong , WU, Wei , DAI, Liguang , DUAN, Xiaowei , YANG, Yanqing , SUN, Yinghui , HAN, Yongxin , PENG, Yong , KONG, Fansheng , LUO, Hong , YANG, Ling , XU, Hongjiang , GUO, Meng , ZHONG, Zhaobai , WANG, Shanchun
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： Provided is an amino pyrazolopyrimidine compound as represented by the following structural formula used as a neurotrophic factor tyrosine kinase receptor inhibitor. The compound can inhibit the activity of Trk kinase and can treat diseases mediated by a Trk tyrosine kinase receptor in mammals.
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公开(公告)号：EP3412669A1
公开(公告)日：2018-12-12
申请号：EP17747001.0
申请日：2017-02-04
申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： LI, Jijun , WU, Wei , ZHU, Yan , WANG, Huting , ZHAO, Lijia , HE, Weinan , SUN, Yinghui , PENG, Yong , HAN, Yongxin
IPC分类号： C07D471/14 , C07D471/04 , A61K31/4375 , A61K31/437 , A61P35/00 , A61P31/12 , A61P25/28 , A61P29/00 , A61P9/10
CPC分类号： A61K31/437 , A61K31/4375 , C07D471/04 , C07D471/14
摘要： The present applicationpresent application relates to a compound represented by Formula (III) or a pharmaceutically acceptable salt, solvent compound, active metabolite, crystal polymorph, ester, isomer, or prodrug thereof. The application further provides a pharmaceutical composition comprising the compound represented by Formula (III) and a use thereof for preparing a bromodomain inhibitor for preventing or treating various diseases, such as inflammation and cancer, related to the bromodomain.
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公开(公告)号：EP2952510B1
公开(公告)日：2018-12-26
申请号：EP14746385.5
申请日：2014-01-27
申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： XIAO, Dengming , XU, Xinhe , LIU, Xijie , HU, Yuandong , YU, Honghao , LIU, Zhihua , PENG, Yong , SUN, Yinghui , LUO, Hong , KONG, Fansheng , HAN, Yongxin , SUN, Jian
IPC分类号： C07D401/04 , C07D213/74 , C07D401/06 , C07D401/14 , C07D213/73 , C07F9/6558 , A61K31/496 , A61K31/675 , A61K31/4545 , A61K31/5377 , A61K31/444 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/675 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07F9/65583
摘要： Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.
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公开(公告)号：EP3235819B1
公开(公告)日：2020-11-18
申请号：EP15869312.7
申请日：2015-12-15
申请人： Centaurus BioPharma Co., Ltd. , Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： ZHU, Li , XIAO, Dengming , HU, Yuandong , DAI, Liguang , DUAN, Xiaowei , SUN, Yinghui , PENG, Yong , KONG, Fansheng , LUO, Hong , HAN, Yongxin , YANG, Ling , WANG, Shanchun
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P35/00
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公开(公告)号：EP2952510A1
公开(公告)日：2015-12-09
申请号：EP14746385.5
申请日：2014-01-27
申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： XIAO, Dengming , XU, Xinhe , LIU, Xijie , HU, Yuandong , YU, Honghao , LIU, Zhihua , PENG, Yong , SUN, Yinghui , LUO, Hong , KONG, Fansheng , HAN, Yongxin , SUN, Jian
IPC分类号： C07D401/04 , C07D213/74 , C07D401/06 , C07D401/14 , C07D213/73 , C07F9/6558 , A61K31/496 , A61K31/675 , A61K31/4545 , A61K31/5377 , A61K31/444 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/675 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07F9/65583
摘要： Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.
摘要翻译： 公开了具有蛋白激酶抑制活性的2-氨基吡啶衍生物，其制备方法和药物组合物。还公开了所述化合物及其药物组合物在制备用于治疗和/或预防蛋白激酶相关疾病的药物中的用途。
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7.发明公开
公开(公告)号：EP3828183A1
公开(公告)日：2021-06-02
申请号：EP19842279.2
申请日：2019-07-25
申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Shouyao Holdings (Beijing) Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： LI, Jijun , ZHU, Yan , WANG, Yeliu , SHANG, Xianxing , WANG, Huting , HE, Weinan , YAN, Qin , SUN, Yinghui , ZHANG, Kai , LU, Chang , XU, Hongjiang , TIAN, Xin , YANG, Ling
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/407 , A61K31/18 , A61P35/00 , A61P35/02
摘要： The present invention relates to a sulfoximine compound represented by formula (I) as a bromodomain protein inhibitor and a pharmaceutically acceptable salt thereof and to a preparation method, pharmaceutical composition, and medical use thereof.
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公开(公告)号：EP2780341B1
公开(公告)日：2019-02-13
申请号：EP12849393.9
申请日：2012-11-14
发明人： XIAO, Dengming , LI, Jijun , ZHU, Yan , HU, Yuandong , WANG, Huting , WANG, Zhe , WANG, Zanping , WEI, Yongheng , SUN, Yinghui , WU, Qiong , ZHANG, Hui , PENG, Yong , KONG, Fansheng , SUN, Ying , LUO, Hong , HAN, Yongxin
IPC分类号： C07D473/00 , C07D487/04 , A61K31/52 , A61P35/00 , A61K31/519 , A61P25/00 , A61P29/00 , A61P37/00
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公开(公告)号：EP2925740A1
公开(公告)日：2015-10-07
申请号：EP13858966.8
申请日：2013-11-29
发明人： HAN, Yongxin , YU, Rong , WANG, Zanping , LIANG, Zhi , HU, Quan , ZHU, Li , HU, Yuandong , SUN, Yinghui , ZHAO, Na , PENG, Yong , ZHAI, Xiaofeng , LUO, Hong , XIAO, Dengming
IPC分类号： C07D401/04 , C07D403/04 , C07D231/38 , A61K31/454 , A61K31/4155 , A61K31/415 , A61K31/5377 , A61K31/496 , A61P37/02 , A61P29/00 , A61P11/06 , A61P19/02 , A61P19/04 , A61P35/00 , A61P35/02
CPC分类号： C07D403/04 , C07D231/38 , C07D401/04
摘要： The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolites, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and is further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provided the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans. Formula (IV)
摘要翻译： 本发明提供由式（IV）表示的新型多取代5-元杂环化合物或其药学上可接受的盐，溶剂化物，代谢物，多晶型物，酯，互变异构体或前药以及包含这些化合物的组合物。 所提供的化合物可以用作选择性不可逆布鲁顿氏酪氨酸激酶（Btk）抑制剂，并且还可用于治疗与异常B细胞增殖有关的炎性自身免疫疾病，例如RA（类风湿性关节炎）和癌症。 本发明还提供了使用式（IV）的药物的制备方法，以及在哺乳动物特别是人类中预防或治疗与过量的Btk活性有关的疾病的方法。 式（IV）
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10.发明公开KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF 审中-公开KINASEMODULIERENDE化合物，组合物和正确使用
公开(公告)号：EP2780341A1
公开(公告)日：2014-09-24
申请号：EP12849393.9
申请日：2012-11-14
发明人： XIAO, Dengming , LI, Jijun , ZHU, Yan , HU, Yuandong , WANG, Huting , WANG, Zhe , WANG, Zanping , WEI, Yongheng , SUN, Yinghui , WU, Qiong , ZHANG, Hui , PENG, Yong , KONG, Fansheng , SUN, Ying , LUO, Hong , HAN, Yongxin
IPC分类号： C07D473/00 , C07D401/04 , A61K31/52 , A61P35/00
CPC分类号： C07D473/00 , C07D487/04
摘要： The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.
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