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公开(公告)号：EP4122931A1
公开(公告)日：2023-01-25
申请号：EP21771264.5
申请日：2021-03-18
发明人： CAI, Zhe , SUN, Fei , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D417/04 , A61K31/519 , A61P31/12
摘要： Disclosed are a crystalline form of a Toll-like receptor 8 (TLR8) agonist as represented by formula (I) and a preparation method therefor. Further provided is an application of the crystalline form in the preparation of a drug for treating a disease responsive to the TLR8 agonist.
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公开(公告)号：EP3854794A1
公开(公告)日：2021-07-28
申请号：EP19862693.9
申请日：2019-09-19
发明人： CAI, Zhe , SUN, Fei , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D471/04 , C07D249/08 , A61K31/519 , A61P31/12
摘要： A TLR8 (Toll-like receptor 8) agonist, a compound of the structure shown in formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.
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3.发明授权
公开(公告)号：EP3412674B1
公开(公告)日：2020-09-16
申请号：EP17747007.7
申请日：2017-02-04
发明人： DING, Zhaozhong , SUN, Fei , HU, Yinghu , ZHOU, Yilong , WANG, Zheng , ZHAO, Rui , YANG, Ling
IPC分类号： C07D487/04 , A61K31/519 , A61P31/12
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公开(公告)号：EP3412673A1
公开(公告)日：2018-12-12
申请号：EP17747006.9
申请日：2017-02-04
发明人： DING, Zhaozhong , SUN, Fei , HU, Yinghu , ZHOU, Yilong , ZHAO, Rui , YANG, Ling
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to a method for preparing a pyrrolo[3,2-d]pyrimidine compound (the compound represented by formula I), and corresponding intermediates.
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公开(公告)号：EP3412672A1
公开(公告)日：2018-12-12
申请号：EP17747004.4
申请日：2017-02-04
发明人： DING, Zhaozhong , SUN, Fei , HU, Yinghu , ZHOU, Yilong , WANG, Zheng , ZHAO, Rui , YANG, Ling
IPC分类号： C07D487/04 , A61K31/519 , A61P31/12
摘要： The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), a method for preparing the crystalline form A, and the use thereof.
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公开(公告)号：EP4324828A1
公开(公告)日：2024-02-21
申请号：EP22787651.3
申请日：2022-04-15
发明人： DING, Charles Z , YAN, Xiaobing , SUN, Fei , JIANG, Wen , LI, Jian , CHEN, Shuhui
IPC分类号： C07D401/14 , C07D401/06 , C07D413/14 , C07D209/02 , A61K31/454 , A61P27/00
摘要： The present application relates to a bicyclic substituted aromatic carboxylic acid compound, and in particular to a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof. In formula (I), R 2 and R 3 and atoms connected thereto together form a 3-6 membered heterocyclic group, or R 2 and R 4 and atoms connected thereto together form a 3-6 membered heterocyclic group. The compound has obvious inhibitory activity on activation of a human serum alternative pathway and significant binding activity to human complement Factor B protein, and also has relatively good in-vivo pharmacodynamic and pharmacokinetic properties.
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7.发明公开
公开(公告)号：EP3412674A1
公开(公告)日：2018-12-12
申请号：EP17747007.7
申请日：2017-02-04
发明人： DING, Zhaozhong , SUN, Fei , HU, Yinghu , ZHOU, Yilong , WANG, Zheng , ZHAO, Rui , YANG, Ling
IPC分类号： C07D487/04 , A61K31/519 , A61P31/12
摘要： The present invention relates to a trifluoroacetate salt of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), crystalline form B of the trifluoroacetate salt, methods for preparing the trifluoroacetate salt and crystalline form B, and uses of the trifluoroacetate salt and crystalline form B.
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公开(公告)号：EP3412673B1
公开(公告)日：2020-11-25
申请号：EP17747006.9
申请日：2017-02-04
发明人： DING, Zhaozhong , SUN, Fei , HU, Yinghu , ZHOU, Yilong , ZHAO, Rui , YANG, Ling
IPC分类号： C07D487/04
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公开(公告)号：EP3712139A1
公开(公告)日：2020-09-23
申请号：EP18879872.2
申请日：2018-11-16
发明人： WU, Lifang , SUN, Fei , DU, Jinhua , DING, Charles Z. , CHEN, Shuhui , ZHANG, Xiquan , XU, Hongjiang , YANG, Ling
IPC分类号： C07D261/00 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/424 , A61K31/4355 , A61K31/437 , A61P31/12
摘要： Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).
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公开(公告)号：EP3412671B1
公开(公告)日：2020-09-16
申请号：EP17747003.6
申请日：2017-02-04
发明人： DING, Zhaozhong , SUN, Fei , HU, Yinghu , ZHOU, Yilong , WANG, Zheng , YANG, Ling
IPC分类号： C07D487/04 , A61K31/519 , A61P31/12
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