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公开(公告)号：EP3712139A1
公开(公告)日：2020-09-23
申请号：EP18879872.2
申请日：2018-11-16
发明人： WU, Lifang , SUN, Fei , DU, Jinhua , DING, Charles Z. , CHEN, Shuhui , ZHANG, Xiquan , XU, Hongjiang , YANG, Ling
IPC分类号： C07D261/00 , C07D413/12 , C07D413/14 , C07D498/04 , A61K31/424 , A61K31/4355 , A61K31/437 , A61P31/12
摘要： Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).
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公开(公告)号：EP4424676A1
公开(公告)日：2024-09-04
申请号：EP22886123.3
申请日：2022-10-28
发明人： LIU, Fei , XU, Hongjiang , PENG, Yan , SHI, Wei , ZHOU, Jiawei , GU, Jiajia
IPC分类号： C07D249/08 , C07D403/14 , C07D401/14 , A61K31/4196 , A61P35/00
CPC分类号： C07D401/14 , C07D249/08 , C07D403/14 , A61P35/00 , A61K31/4196
摘要： Provided are a pyridyl-containing compound represented by formula I and a preparation method therefor, and the use thereof in the preparation for a drug for treating tumors.
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公开(公告)号：EP4357361A1
公开(公告)日：2024-04-24
申请号：EP22824301.0
申请日：2022-06-17
发明人： LONG, Xi , XU, Hongjiang , SHI, Wei , WANG, Liangliang , LU, Zhenzhen
IPC分类号： C07K16/24 , C07K16/28 , G01N33/564 , A61P17/06 , A61P37/06
CPC分类号： C07K16/24 , C07K16/28 , A61P37/06 , G01N33/564 , A61P17/06
摘要： Provided are an anti-IL-36R antibody and a use thereof. In particular, a mouse, chimeric or humanized antibody or an antigen-binding fragment thereof binding to IL-36R is provided; further provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, as well as an expression vector and host cell used to express the antibody or the antigen-binding fragment thereof. In addition, a preparation method and a use of the antibody or the antigen-binding fragment thereof are provided, comprising treatment and prevention of IL-36/IL-36R-mediated diseases and disorders.
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公开(公告)号：EP3865483A1
公开(公告)日：2021-08-18
申请号：EP19870704.4
申请日：2019-10-12
发明人： XU, Hongjiang , ZHANG, Mincheng , ZHANG, Ying , SONG, Wei , YANG, Ling , ZHANG, Xiquan
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Disclosed are a compound of formula I as a toll-like receptor 7 (TLR7) agonist or a pharmaceutically acceptable salt thereof for treating colorectal cancer, a pharmaceutical combination for treating colorectal cancer comprising the TLR7 agonist and a tyrosine kinase inhibitor, and the use of the compound of formula I or the pharmaceutically acceptable salt thereof and the pharmaceutical combination for treating colorectal cancer.
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公开(公告)号：EP3443954A1
公开(公告)日：2019-02-20
申请号：EP17781942.2
申请日：2017-04-14
发明人： GU, Hongmei , WANG, Shanchun , ZHANG, Xiquan , HUANG, Lei , XU, Hongjiang , SONG, Wei , DONG, Ping , SUN, Zhongying , ZHANG, Ying , CHEN, Deyang
IPC分类号： A61K9/72 , A61K9/12 , A61K31/704 , A61P1/16 , A61P31/12
摘要： The present invention belongs to the field of medicine, relates to an inhaled preparation of isoglycyrrhizic acid or a salt thereof, and in particular relates to an inhaled preparation of magnesium isoglycyrrhizinate and the use thereof in preparing drugs for treating respiratory system diseases.
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公开(公告)号：EP4406971A1
公开(公告)日：2024-07-31
申请号：EP22872081.9
申请日：2022-09-23
发明人： LU, Zhenzhen , WANG, Yujie , ZHANG, Zhengping , XU, Hongjiang , ZHAO, Wei
摘要： Provided are an anti-CD40 antibody and a use thereof, such as a mouse, human, chimeric, or humanized antibody specifically binding to CD40, and an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, and an expression vector and a host cell for expressing the antibody or the antigen-binding fragment thereof. Further provided are a preparation method and a use method for the antibody or the antigen-binding fragment thereof, comprising treating and preventing immune diseases.
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公开(公告)号：EP4130042A1
公开(公告)日：2023-02-08
申请号：EP21780305.5
申请日：2021-04-01
发明人： GUI, Qiu , ZHU, Hong , WANG, Liangliang , ZHANG, Xiaoyun , ZOU, Xiaofang , SHEN, Hengqiao , XU, Hongjiang , YANG, Ling
摘要： Provided are an antigen-binding polypeptide binding to CD47 or an antigen-binding portion thereof, nucleic acids encoding the polypeptide, vector, cell or pharmaceutical composition. The polypeptide can reduce a tumor or inhibit the growth of tumor cells, treat cancer, promote macrophage phagocytosis, and the like.
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公开(公告)号：EP4110816A1
公开(公告)日：2023-01-04
申请号：EP21712942.8
申请日：2021-02-25
发明人： CHEN, Mingjiu , TAN, Wei , ZHONG, Cathy Xiaoyan , MA, Mark Zhiqing , XIA, Shukai , ZHANG, Zhengping , XU, Hongjiang , LU, Zhijian
IPC分类号： C07K16/28
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公开(公告)号：EP3858832A1
公开(公告)日：2021-08-04
申请号：EP19878278.1
申请日：2019-10-29
发明人： LIU, Fei , FENG, Weiwei , WANG, Bin , XU, Hongjiang , WANG, Jinan , ZHANG, Xiquan , WANG, Shanchun , LIU, Yanlong , ZHANG, Jianqing , YAO, Yiyan , TANG, Xujing , SHI, Wei , ZHANG, Hongying , LI, Yang , TANG, Song , ZHU, Yizhong , LIU, Limin , GU, Hongmei , YANG, Ling
IPC分类号： C07D471/04 , C07D211/96 , C07D215/20 , A61K31/404 , A61P35/00
摘要： Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.
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公开(公告)号：EP3851439A1
公开(公告)日：2021-07-21
申请号：EP19861061.0
申请日：2019-09-12
发明人： ZHANG, Yinsheng , XU, Hongjiang , REN, Jing , WANG, Qinglin , WU, Zheyang , JIN, Chao , SHI, Wei , WANG, Xiaojin , HE, Xiangyi , CHANG, Xiayun , WANG, Jie , ZHAO, Tianxiao
IPC分类号： C07D487/04 , A61K31/4985 , A61P19/02
摘要： The present application belongs to the field of pharmaceutical chemistry, and relates to a furo[3,4-b]pyrrole-containing BTK inhibitor, and in particular, to a compound of formula (I), a stereisomer or pharmacologically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in treating BTK-related diseases.
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