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公开(公告)号：EP3383852A2
公开(公告)日：2018-10-10
申请号：EP16871440.0
申请日：2016-11-30
发明人： ZETTER, Bruce, R. , SUN, Lijun
IPC分类号： C07D235/32 , C07D405/12 , C07D403/12 , C07D401/14 , A61K31/4184
CPC分类号： C07D405/12 , C07D235/32
摘要： The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
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公开(公告)号：EP3889139A1
公开(公告)日：2021-10-06
申请号：EP21156104.8
申请日：2016-11-30
发明人： ZETTER, Bruce, R. , SUN, Lijun
IPC分类号： C07D235/32 , C07D405/12 , A61P35/00 , A61K31/4184
摘要： The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
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公开(公告)号：EP0934412A1
公开(公告)日：1999-08-11
申请号：EP97929992.0
申请日：1997-06-13
发明人： ZETTER, Bruce, R. , BAO, Lere
IPC分类号： G01N33 , A61K31 , A61K39 , A61K48 , A61P35 , A61P43 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , A61K38
CPC分类号： C07K16/26 , A61K38/00 , C07K14/57581 , C07K2319/00
摘要： The present inventors have now discovered that humans have a gene that encodes a novel protein of the thymosin β family. This novel protein, herein referred to as thymosin β15, has the ability to bind and sequester G-actin, like other members of the thymosin β family, but unlike what is known about other members it also directly regulates cell motility in prostatic carcinoma cells. The present invention is directed to an isolated cDNA encoding the human thymosin β15 gene (SEQ ID NO: 1) and have deduced the amino acid sequence (SEQ ID NO: 2).
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公开(公告)号：EP1948213B1
公开(公告)日：2009-02-04
申请号：EP06838008.8
申请日：2006-11-17
CPC分类号： G01N33/6893 , A61K38/00 , A61K38/45 , A61K51/00 , C07K16/18 , C07K2317/55 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12Y205/01018 , G01N33/574 , G01N33/94 , G01N2800/44 , G01N2800/7028
摘要： Embodiments of the invention are directed to methods for predicting the resistance of cancer to members of the taxoid family by measuring the levels of prohibitin. Methods for treating cancer and taxoid family member resistant cancers using inhibitors of prohibitin, as well as therapeutic complexes that target prohibitin are also provided.
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公开(公告)号：EP1948213A2
公开(公告)日：2008-07-30
申请号：EP06838008.8
申请日：2006-11-17
IPC分类号： A61K38/08
CPC分类号： G01N33/6893 , A61K38/00 , A61K38/45 , A61K51/00 , C07K16/18 , C07K2317/55 , C07K2317/76 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12Y205/01018 , G01N33/574 , G01N33/94 , G01N2800/44 , G01N2800/7028
摘要： Embodiments of the invention are directed to methods for predicting the resistance of cancer to members of the taxoid family by measuring the levels of prohibitin. Methods for treating cancer and taxoid family member resistant cancers using inhibitors of prohibitin, as well as therapeutic complexes that target prohibitin are also provided.
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公开(公告)号：EP0934412B1
公开(公告)日：2005-01-26
申请号：EP97929992.2
申请日：1997-06-13
发明人： ZETTER, Bruce, R. , BAO, Lere
CPC分类号： C07K16/26 , A61K38/00 , C07K14/57581 , C07K2319/00
摘要： The present inventors have now discovered that humans have a gene that encodes a novel protein of the thymosin beta family. This novel protein, herein referred to as thymosin beta 15, has the ability to bind and sequester G-actin, like other members of the thymosin beta family, but unlike what is known about other members it also directly regulates cell motility in prostatic carcinoma cells. The present invention is directed to an isolated cDNA encoding the human thymosin beta 15 gene (SEQ ID NO: 1) and have deduced the amino acid sequence (SEQ ID NO: 2).
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公开(公告)号：EP1842065B1
公开(公告)日：2010-12-01
申请号：EP06719762.4
申请日：2006-01-30
IPC分类号： G01N33/53 , G01N33/574 , C12Q1/70 , C07K16/00
CPC分类号： G01N33/57407 , G01N33/57488 , G01N33/6893 , G01N2333/8139
摘要： The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.
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8.发明公开METHODS FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS 有权DIAGNOSE- UND PROGNOSEVERFAHREN VON BLASENKREBS。
公开(公告)号：EP1842065A2
公开(公告)日：2007-10-10
申请号：EP06719762.4
申请日：2006-01-30
IPC分类号： G01N33/53 , G01N33/574 , C12Q1/70 , C07K16/00
CPC分类号： G01N33/57407 , G01N33/57488 , G01N33/6893 , G01N2333/8139
摘要： The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.
摘要翻译： 本发明是基于以下发现：三种蛋白质，半胱氨酸蛋白酶抑制剂B，伴侣蛋白10和Profilin存在于患有膀胱癌，上皮起源的癌症的患者的尿液中。 因此，本发明涉及通过监测生物样品中这些标记物的存在来预测上皮来源癌症的方法和促进上皮癌起病癌症诊断的方法。 本发明还涉及用于治疗功效的标志物。
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公开(公告)号：EP0922223B1
公开(公告)日：2003-04-02
申请号：EP97931170.1
申请日：1997-06-13
发明人： ZETTER, Bruce, R. , BAO, Lere
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/118 , G01N33/57407 , G01N33/57415 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57488 , G01N2333/5759 , Y10S435/81
摘要： The present inventors have discovered that humans have a gene that encodes a novel protein of the thymosin beta family. This novel protein, herein referred to as thymosin beta 15, has the ability to bind and sequester G-actin, like other members of the thymosin beta family, but unlike what is known about other members also directly regulates cell motility in prostatic carcinoma cells. A cDNA of the human thymosin beta 15 gene (SEQ ID NO: 1) and having deduced the amino acid sequence (SEQ ID NO: 2) was isolated. The present inventors have shown that enhanced transcripts (mRNA) and expression of the thymosin beta 15 gene in non-testicular cells has a high correlation to disease state in a number of cancers, such as prostate, lung, melanoma and breast cancer, particularly metastatic cancers. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be used in not only a diagnostic manner, but a prognostic manner for particular cancers.
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公开(公告)号：EP0922223A1
公开(公告)日：1999-06-16
申请号：EP97931170.0
申请日：1997-06-13
发明人： ZETTER, Bruce, R. , BAO, Lere
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/118 , G01N33/57407 , G01N33/57415 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57488 , G01N2333/5759 , Y10S435/81
摘要： The present inventors have discovered that humans have a gene that encodes a novel protein of the thymosin β family. This novel protein, herein referred to as thymosin β15, has the ability to bind and sequester G-actin, like other members of the thymosin β family, but unlike what is known about other members also directly regulates cell motility in prostatic carcinoma cells. A cDNA of the human thymosin β15 gene (SEQ ID NO: 1) and having deduced the amino acid sequence (SEQ ID NO: 2) was isolated. The present inventors have shown that enhanced transcripts (mRNA) and expression of the thymosin β15 gene in non-testicular cells has a high correlation to disease state in a number of cancers, such as prostate, lung, melanoma and breast cancer, particularly metastatic cancers. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be used in not only a diagnostic manner, but a prognostic manner for particular cancers.
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