专利检索 ap:("Children's Medical Center Corporation" OR "President AND Fellows of Harvard College" OR "Joslin Diabetes Center, Inc.") AND inv:"KAHN, C. Ronald" 第 1 页

1.

发明公开
HIGH-THROUGHPUT IMAGE-BASED CHEMICAL SCREENING IN ZEBRAFISH BLASTOMERE CELL CULTURE 审中-公开
标题翻译：在斑马鱼卵裂球细胞培养基于图像的化学高通量筛选

公开(公告)号：EP2825637A1

公开(公告)日：2015-01-21

申请号：EP13761095.2

申请日：2013-03-14

申请人： Children's Medical Center Corporation , President and Fellows of Harvard College , Joslin Diabetes Center, Inc.

发明人： ZON, Leonard I. , XU, Cong , WAGERS, Amy J. , KAHN, C. Ronald

IPC分类号： C12N5/071 , C12N5/02 , A61K35/12 , G01N33/58

CPC分类号： C12N5/0658 , A61K35/545 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/28 , A61K38/30 , C12N2501/01 , C12N2501/115 , C12N2501/16 , C12N2501/999 , C12N2506/02 , C12N2506/45 , G01N33/5044 , G01N33/56983 , Y02A50/471 , A61K2300/00

摘要： Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of cells for transplantation in a subject in need thereof. Also disclosed is a screening assay for screening test compounds using blastomere cultures.

2.

发明公开
GLYPICAN-4 BASED COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING INSULIN RESISTANCE 审中-公开
标题翻译：磷脂酰肌醇-4为基础的治疗和诊断的胰岛素抵抗组合物和方法

公开(公告)号：EP2797619A1

公开(公告)日：2014-11-05

申请号：EP12863353.4

申请日：2012-12-31

申请人： Joslin Diabetes Center, Inc.

发明人： USSAR, Siegfried , KAHN, C. Ronald

IPC分类号： A61K38/17

CPC分类号： A61K38/1709 , G01N33/6893

摘要： Provided herein are methods for increasing insulin sensitivity in a subject. A method may comprise administering to a subject in need of increased insulin sensitivity a therapeutically effective amount of a glypican-4 agent. Also provided herein are methods for determining whether a subject is or is likely to become insulin resistant. A method may comprise determining the level of glypican-4 in a subject, wherein an elevated level of glypican-4 indicates that a subject is or is likely to become insulin resistant.

3.

发明公开
COMPOSITIONS AND METHODS FOR THE TREATMENT OF NERVOUS DISORDERS ASSOCIATED WITH DIABETES 审中-公开
标题翻译：组合物和方法患有糖尿病CONNECTION治疗神经扰动

公开(公告)号：EP2646046A2

公开(公告)日：2013-10-09

申请号：EP11845706.8

申请日：2011-11-29

申请人： Joslin Diabetes Center, Inc.

发明人： KAHN, C. Ronald , SUZUKI, Ryo

IPC分类号： A61K38/28

CPC分类号： A61K38/28 , G01N33/53

摘要： Compositions and methods for treating neural dysfunction. A exemplary method comprises administering to a subject having a neuropathy, e.g., a cognitive dysfunction or Alzheimer's, a therapeutically effective amount of an insulin or insulin analog, wherein the insulin or insulin analog crosses the BBB and/or a compound that increases SREBP-2 expression or activity in the CNS of the subject.

4.

发明公开
USE OF PROTEIN KINASE C DELTA (PKCD) INHIBITORS TO TREAT DIABETES, OBESITY, AND HEPATIC STEATOSIS 审中-公开
标题翻译：蛋白激酶C-DELTA（PKCD-）抑制剂在糖尿病，肥胖症和脂肪肝治疗中的用途

公开(公告)号：EP2482837A2

公开(公告)日：2012-08-08

申请号：EP10821157.4

申请日：2010-09-29

申请人： Joslin Diabetes Center, Inc.

发明人： KAHN, C. Ronald , BEZY, Olivier

IPC分类号： A61K38/16 , A61K38/17 , A61K31/7105 , A61K31/7088 , A61P3/04 , A61P3/10

CPC分类号： A61K31/7088 , A61K31/7105 , A61K38/04 , A61K38/1709

摘要： Described are methods of improving insulin sensitivity, and treating fatty liver disease (including non-alcoholic steatohepatitis (NASH)), by administering specific inhibitors of PKC delta.