公开(公告)号：EP4349364A1

公开(公告)日：2024-04-10

申请号：EP22816408.3

申请日：2022-05-30

申请人： Chung Ang University Industry Academic Cooperation Foundation

发明人： KIM, Dae Kyong

IPC分类号： A61K38/17 ,  A61P9/00 ,  A23L33/17

摘要： The present invention relates to a composition for repairing vascular degeneration and vascular injuries and preventing or treating vascular diseases, containing hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient. More specifically, provided is a pharmaceutical composition and a health functional food composition for preventing or treating vascular diseases, containing HAPLN1 as an active ingredient. HAPLN1 inhibits and alleviates, in blood vessel walls, damage to the elastin fiber layer and loss of transgelin, and effectively inhibits the phosphorylation of NF-κB or focal adhesion kinase (FAK) in vascular smooth muscle cells (VSMCs), and thus can be used for preventing, alleviating or treating vascular injuries and various diseases caused by aging or a high-fat diet.

公开(公告)号：EP4382115A1

公开(公告)日：2024-06-12

申请号：EP22853439.2

申请日：2022-08-02

申请人： Chung Ang University Industry Academic Cooperation Foundation ,  HAPLNSCIENCE INC.

发明人： KIM, Dae Kyong ,  KIM, Yong Soon ,  BACK, Moon Jung ,  PYO, Jung Hoon ,  KIM, David ,  PIAO, Yong Wei ,  YEOM, Min A

IPC分类号： A61K38/16 ,  A61K45/06 ,  A61P43/00

CPC分类号： A61P43/00 ,  A61K38/16 ,  A61K45/06

摘要： Disclosed in the present disclosure are, a pharmaceutical composition for preventing or treating a fibrotic disease including a hyaluronan and proteoglycan link protein 1 (HAPLN1) or a gene encoding the same as an active ingredient, and a method for preventing or treating the fibrotic disease using the composition. According to the present disclosure, by preventing and inhibiting fibrosis of cells or tissues, the development or progression of various diseases caused by fibrosis may be fundamentally inhibited, thereby preventing or treating such diseases.