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1.发明公开CYTOCHROME P450 MONOOXYGENASE AND NADPH CYTOCHROME P450 OXIDOREDUCTASE GENES AND PROTEINS RELATED TO THE OMEGA HYDROXYLASE COMPLEX OF CANDIDA TROPICALIS AND METHODS RELATING THERETO 有权细胞色素P450单加氧酶和NADPH - 细胞色素P450氧化还原酶基因和蛋白相对于欧米茄羟化酶复杂热带假丝酵母，和相关方法
公开(公告)号：EP1135506A2
公开(公告)日：2001-09-26
申请号：EP99946862.2
申请日：1999-09-10
申请人： Cognis Corporation
发明人： WILSON, C., Ron , CRAFT, David, L. , EIRICH, L., Dudley , ESHOO, Mark , MADDURI, Krishna M. , CORNETT, Cathy A.,Apartment 11 , BRENNER, Alfred, A. , TANG, Maria , LOPER, John, C. , GLEESON, Martin
CPC分类号： C12N9/0042 , C07K14/40 , C12N9/0071 , C12N9/0077 , C12P7/44
摘要： Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzyme of the φ-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells and transformed host cells are provided. Methods of producing of cytochrome P450 and NADPH reductase enzymes are also provided which involve transforming a host cell with a gene encoding these enzymes and culturing the cells. Methods of increasing the production of a dicarboxylic acid and methods of increasing production of the aforementioned enzymes are also provided which involve increasing in the host cell the number of genes encoding these enzymes. A method for discriminating members of a gene family by quantifying the expression of genes is also provided.
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2.发明授权CYTOCHROME P450 MONOOXYGENASE AND NADPH CYTOCHROME P450 OXIDOREDUCTASE GENES AND PROTEINS RELATED TO THE OMEGA HYDROXYLASE COMPLEX OF CANDIDA TROPICALIS AND METHODS RELATING THERETO 有权细胞色素P450单加氧酶和NADPH - 细胞色素P450氧化还原酶基因和蛋白相对于欧米茄羟化酶复杂热带假丝酵母，和相关方法
公开(公告)号：EP1135506B1
公开(公告)日：2005-04-20
申请号：EP99946862.2
申请日：1999-09-10
申请人： Cognis Corporation
发明人： WILSON, C., Ron , CRAFT, David, L. , EIRICH, L., Dudley , ESHOO, Mark , MADDURI, Krishna M. , CORNETT, Cathy A., Apartment 11 , BRENNER, Alfred, A. , TANG, Maria , LOPER, John, C. , GLEESON, Martin
CPC分类号： C12N9/0042 , C07K14/40 , C12N9/0071 , C12N9/0077 , C12P7/44
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