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公开(公告)号：EP1244771A1
公开(公告)日：2002-10-02
申请号：EP01901830.8
申请日：2001-01-05
申请人： Cognis Corporation
CPC分类号： C12P7/6409 , C12N1/16 , C12P7/6436
摘要： A fermentation medium containing: (a) a source of metabolizable carbon and energy; (b) a source of inorganic nitrogen; (c) a source of phosphate; (d) at least one metal selected from the group consisting of an alkali metal, an alkaline earth metal, a transition metal, and mixtures thereof; and (e) biotin, substantially free of particulate matter and bacteria. A fatty material may be added to an aqueous suspension containing at least one dicarboxylic acid to modify the rheological characteristics of the suspension.
摘要翻译： 发酵培养基含有：（a）可代谢的碳和能量来源; （b）无机氮的来源; （c）磷酸盐的来源; （d）至少一种选自碱金属，碱土金属，过渡金属及其混合物的金属; 和（e）生物素，基本上不含颗粒物和细菌。 可以将脂肪物质添加到含有至少一种二羧酸的含水悬浮液中以改变悬浮液的流变特性。
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公开(公告)号：EP1114174A1
公开(公告)日：2001-07-11
申请号：EP98948100.7
申请日：1998-09-17
申请人： Cognis Corporation
摘要： Aliphatic polycarboxylic acids are made by a process comprising the steps of: (1) fermenting a beta-oxidation blocked C. tropicalis cell wherein both copies of the chromosomal POX5 gene and the chromosomal POX4A and POX4B genes are disrupted in a culture medium comprised of a nitrogen source, an organic substrate and a cosubstrate wherein the substrate is an unsaturated aliphatic compound having at least one internal carbon-carbon double bond and at least one terminal methyl group, a terminal carboxyl group and/or a terminal functional group which is oxidizable to a carboxyl group by biooxidation; (2) reacting the product of step (1) with an oxidizing agent to produce one or more polycarboxylic acids.
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公开(公告)号：EP1587936A2
公开(公告)日：2005-10-26
申请号：EP04702190.2
申请日：2004-01-14
申请人： Cognis Corporation
CPC分类号： C12P7/6409 , C12P7/44 , C12P7/46
摘要： Biooxidation reactions can be controlled by a method which comprises the steps of: (1) independently adding a substrate and a co-substrate at predetermined rates to a bioxidation reaction mixture comprised of a biocatalyst; (2) measuring the oxygen consumption rate and carbon dioxide evolution rate from the reaction mixture; (3) determining the instantaneous rates of substrate and cosubstrate consumption by solving simultaneous equations relating carbon dioxide evolution rate and oxygen consumption rate to the substrate oxidation stoichiometry, the cosubstrate combustion stoichiometry, and optionally the biomass formation stoichiometry; (4) simultaneously adjusting the substrate and cosubstrate addition rates to the rates of substrate oxidation and cosubstrate consumption in order to maximize the rate of product formation while simultaneously minimizing the rate of cosubstrate usage. The method provides a rapid means of controlling fed-batch biooxidation reactions which can employ in-line techniques and is broadly applicable for diverse oxidation reactions.
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公开(公告)号：EP1220939A1
公开(公告)日：2002-07-10
申请号：EP00965377.5
申请日：2000-09-22
申请人： Cognis Corporation
IPC分类号： C12P7/02
CPC分类号： C12P7/6409 , C12N1/16
摘要： A fermentation medium containing: (a) a source of metabolizable carbon and energy; (b) a source of inorganic nitrogen; (c) a source of phosphate; (d) at least one metal selected from the group consisting of an alkali metal, an alkaline earth metal, a transition metal, and mixtures thereof; and (e) biotin, substantially free of particulate matter and bacteria.
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