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公开(公告)号：EP1303593B1
公开(公告)日：2008-01-09
申请号：EP01953603.6
申请日：2001-07-25
IPC分类号： C12N15/00
CPC分类号： C12N15/81
摘要： A nucleic acid sequence including a CYP promoter operably linked to nucleic acid encoding a heterologous protein is provided to increase transcription of the nucleic acid. Expression vectors and host cells containing the nucleic acid sequence are also provided. The methods and compositions described herein are especially useful in the production of polycarboxylic acids by yeast cells.
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2.发明授权FATTY ALCOHOL OXIDASE GENES AND PROTEINS FROM CANDIDA TROPLICALIS AND METHODS RELATING THERETO 有权FETTALKOHOLOXIDASE基因和蛋白质OFF热带念珠菌和相关程序
公开(公告)号：EP1576095B1
公开(公告)日：2011-12-21
申请号：EP03724119.7
申请日：2003-04-18
IPC分类号： C12N9/00 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/34 , C12Q1/68 , C12P21/06 , C12P21/04 , A61K38/44 , C07H21/04 , C07K1/00
CPC分类号： C12N9/0006
摘要： The present invention provides fatty alcohol oxidase (FAO) proteins and nucleic acid molecules encoding the FAO proteins. Also provided are analogs, derivatives, and enzymatically active fragments of the FAO proteins. Vectors and host cells comprising the nucleic acid molecules encoding the FAO proteins, analogs, derivatives and enzymatically active fragments thereof are also provided. In addition, Fao signature peptides and isolated nucleic acid molecules encoding the signature peptides are provided by the present invention. Methods of producing or increasing production of a subject FAO protein, methods for increasing aldehyde production during the second step of the ω-oxidation pathway of fatty acids, methods for increasing production of a ketone from an alcohol during the second step of the ω-oxidation pathway of fatty acids, and methods for increasing production of a dicarboxylic acid are also provided.
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3.发明授权CYTOCHROME B5 GENE AND PROTEIN OF CANDIDA TROPICALIS AND METHODS RELATING THERETO 有权热带假丝酵母的细胞色素b基因和蛋白及其用途
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