公开(公告)号：EP1984110B1

公开(公告)日：2011-10-19

申请号：EP07730986.2

申请日：2007-02-15

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  BIOMERIEUX

发明人： DELATTRE, Cyril ,  CHARLES, Raymond ,  POUTEAU, Patrick

IPC分类号： B01J19/00 ,  B01L3/00

CPC分类号： B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00418 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/0074 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00959 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/0487 ,  B01L2400/0688 ,  Y10T137/0396 ,  Y10T137/2224 ,  Y10T137/87306 ,  Y10T137/87499

摘要： The method for controlling the downstream progress of a liquid in a microfluid component, comprising, for example, a number of microchannels, each having a number of successive reaction or detection zones and a number of passive valves, controls the progress of the liquid in the microchannels by controlling the increase of pressure differential between the upstream and downstream end of the component. The method controls the increase in pressure differential in a discontinuous manner in the form of release pulses (Pd), such as to particularly synchronise the passage through the corresponding passive valves in the microchannels. The pressure difference is reduced to a zero value between two successive release pulses (Pd).

公开(公告)号：EP2350677A1

公开(公告)日：2011-08-03

申请号：EP09760243.7

申请日：2009-10-30

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Biomérieux

发明人： BROYER, Patrick ,  DURIN, Guillaume ,  DELATTRE, Cyril ,  FOUCAULT, Frédéric

IPC分类号： G01N35/10

CPC分类号： G01N35/1079 ,  B01L3/021 ,  B01L3/50853 ,  B01L3/50855 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/087 ,  Y10T29/49826

摘要： The invention relates to a device for preparing and/or treating a biological sample including an assembly (2) of storage chambers (3) and/or reaction chambers intended for receiving a fluid and means arranged to move an amount of fluid from and/or to at least one of the chambers (3) of the assembly (2) of chambers (3), the chambers (3) being separated by walls (5) so as to form an assembly of adjacent chambers (3) aligned in a given direction. The means arranged to move an amount of fluid include a needle (6) connected to a transfer space (9), means (8) arranged to enable the suction of a liquid towards a chamber (3) from a transfer space (9) via a needle or delivery from the transfer space (9) to a chamber (3), and driving means (7) arranged to translate the needle (6) and the assembly (2) of chambers relative to one another in the chamber (3) alignment direction, and in that two adjacent chambers (3) are separated by a wall including a sealing membrane (5) or septum capable of being pierced by the needle (6) and of then recovering the seal thereof once the needle is removed. The invention also relates to a method for manufacturing such a device.

公开(公告)号：EP2350677B1

公开(公告)日：2016-09-07

申请号：EP09760243.7

申请日：2009-10-30

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Biomérieux

发明人： BROYER, Patrick ,  DURIN, Guillaume ,  DELATTRE, Cyril ,  FOUCAULT, Frédéric

IPC分类号： G01N35/10

CPC分类号： G01N35/1079 ,  B01L3/021 ,  B01L3/50853 ,  B01L3/50855 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2200/141 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/087 ,  Y10T29/49826

公开(公告)号：EP2547432B1

公开(公告)日：2014-04-30

申请号：EP11708509.2

申请日：2011-03-18

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： NIKOLOVSKI, Jean-Pierre ,  DELATTRE, Cyril

IPC分类号： B01F11/02

CPC分类号： B01F11/0266 ,  B01F2215/0037

公开(公告)号：EP2547432A1

公开(公告)日：2013-01-23

申请号：EP11708509.2

申请日：2011-03-18

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： NIKOLOVSKI, Jean-Pierre ,  DELATTRE, Cyril

IPC分类号： B01F11/02

CPC分类号： B01F11/0266 ,  B01F2215/0037

摘要： An agitator by vibrations includes an annular resonator (12) to which is applied a vibratory stress by piezoelectric transducers (15, 16). The preferred stress shape is a bending of the ring (12) perpendicularly to its plane in order to excite inherent modes at relatively low frequencies. The use of a solid annular transmitter enables the vibrations to be satisfactorily controlled in order to maintain satisfactory transmission to the sample (7) to be agitated, and to focus them on it. The excitation frequencies are frequencies inherent to the ring or to the tank (6).

公开(公告)号：EP3289333A1

公开(公告)日：2018-03-07

申请号：EP16730887.3

申请日：2016-04-26

申请人： Illumina France SARL ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： DELATTRE, Cyril ,  RIVAL, Arnaud ,  ALLIER, Cédric

IPC分类号： G01N15/14 ,  G01N15/10

CPC分类号： G01N21/17 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N2015/0053 ,  G01N2015/1006 ,  G01N2015/1481 ,  G01N2021/1765

摘要： In accordance with embodiments herein, microfluidics systems and methods are described for identifying and/or tracking particles in a droplet. For example, the particle may be a bead, a cell, or any other type of particle. For example, embodiments herein are useful in distinguishing cells from other particles. The microfluidics systems and methods provide the capability to image a large area (e.g., a few square millimeters) within a digital fluidics chamber using interference microscopy, wherein the image of the interference pattern is acquired, instead of an image of the micrometric object itself. The interference pattern results from the incoming light that interferes with the light scattered by the object. In the case of micrometric objects (e.g., cells, bacteria, etc.), the acquired interference pattern may typically be about 100 jum in diameter so that the area can be imaged using a lens-free imaging configuration or using a low magnification lens.

公开(公告)号：EP2433130A2

公开(公告)日：2012-03-28

申请号：EP10727008.4

申请日：2010-05-17

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： DURIN, Guillaume ,  CHABAUD, Sylvaine ,  DELATTRE, Cyril ,  JARY, Dorothée

IPC分类号： G01N33/543 ,  C12N1/02 ,  C12M1/26 ,  C12Q1/24 ,  C12Q1/68 ,  G01N33/569 ,  G01N33/68 ,  B03C1/02

CPC分类号： G01N33/56911 ,  G01N33/54326

摘要： The present invention relates to a device for collecting and concentrating biological or chemical targets with a view to detecting same, wherein the device includes a reaction chamber (1) in which functionalized magnetic beads (2) are placed, an ultrasonic agitation system (3), a magnetic field (4) that can be activated (ON position) or inactivated (OFF position), and a fluid movement system (5) for feeding (51) and discharging (52) a portion or the entirety of the contents of the reaction chamber. The invention also relates to a method for capturing biological or chemical targets implementing said device.

公开(公告)号：EP1984110A1

公开(公告)日：2008-10-29

申请号：EP07730986.2

申请日：2007-02-15

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ,  BIOMERIEUX

发明人： DELATTRE, Cyril ,  CHARLES, Raymond ,  POUTEAU, Patrick

IPC分类号： B01J19/00 ,  B01L3/00

CPC分类号： B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00418 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/0074 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00959 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/0487 ,  B01L2400/0688 ,  Y10T137/0396 ,  Y10T137/2224 ,  Y10T137/87306 ,  Y10T137/87499

摘要： The method for controlling the downstream progress of a liquid in a microfluid component, comprising, for example, a number of microchannels, each having a number of successive reaction or detection zones and a number of passive valves, controls the progress of the liquid in the microchannels by controlling the increase of pressure differential between the upstream and downstream end of the component. The method controls the increase in pressure differential in a discontinuous manner in the form of release pulses (Pd), such as to particularly synchronise the passage through the corresponding passive valves in the microchannels. The pressure difference is reduced to a zero value between two successive release pulses (Pd).

公开(公告)号：EP1682273A1

公开(公告)日：2006-07-26

申请号：EP04805768.1

申请日：2004-10-21

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ,  BIOMERIEUX SA

发明人： DELATTRE, Cyril ,  MARCHAND, Gilles ,  POUTEAU, Patrick ,  GINOT, Frédéric

IPC分类号： B01L3/00 ,  B01J19/00

CPC分类号： B01L3/5085 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/0065 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0487 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

摘要： The invention concerns a working device (1) comprising working zones. It enables matrices of drops to be obtained on a surface, derived from a liquid of interest (E). It comprises a working box (Bo) provided with means for introducing and extracting (o, s) the liquid into and from the box; a substrate (S) comprising an active surface substantially non wetting with respect to said liquid of interest enclosed in said box.; working zones (Zt) formed separately on said active surface and surrounded each by an edge (b) formed on said active surface, the edges not contiguous to one another with no common boundary therebetween, and having a geometry such that when the liquid of interest is extracted from the box, one drop (g) of the liquid of interest remains trapped by each edge and in contact with said working zone surrounded thereby.

公开(公告)号：EP1677913A1

公开(公告)日：2006-07-12

申请号：EP04805769.9

申请日：2004-10-21

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ,  BIOMERIEUX SA

发明人： MARCHAND, Gilles ,  DELATTRE, Cyril ,  POUTEAU, Patrick ,  CAILLAT, Patrice

IPC分类号： B01L3/00 ,  B01J19/00

CPC分类号： B01L3/502792 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/0065 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0487 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

摘要： The invention concerns a working device characterized in that it comprises an active surface (Sa) substantially non wetting with respect to a liquid of interest; at least one localized capture zone (Zc) of a drop of said liquid, formed on said active surface; at least one working zone (Zt) arranged with a capture zone such that the working zone is covered at least partly by a drop of the liquid when the latter is captured by said capture zone; and means for allowing a drop of said liquid to remain on said capture zone. Said device enables in particular high density matrices of drops of said liquid to be formed on a surface, in particular for performing chemical or biochemical reactions and/or for analyzing the liquid of interest at each drop. The invention is applicable in biological chips.