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1.发明公开
公开(公告)号：EP3144014A8
公开(公告)日：2017-04-26
申请号：EP15306469.6
申请日：2015-09-21
申请人： COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： GIACOSA, Sofia , PILLET, Catherine , COCHET, Claude , FILHOL-COCHET, Odile , BARETTE, Caroline , SOLEILHAC, Emmanuelle
IPC分类号： A61K45/06 , A61K31/437 , A61K31/4375 , A61K31/5377 , A61P35/00 , A61P35/04
CPC分类号： A61K31/4375 , A61K31/437 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention pertains to a novel treatment of renal cell carcinoma and other a solid tumors which harbor a VHL inactivation, based on the combination of a first agent inhibiting a protein kinase CK2 (CK2) and a second agent inhibiting an Ataxia Telangiectasia Mutated (ATM) kinase.
摘要翻译： 本发明涉及基于抑制蛋白激酶CK2（CK2）的第一试剂和抑制共济失调毛细血管扩张症突变（ATM）的第二试剂的组合的，具有VHL失活的肾细胞癌和其他实体瘤的新型治疗 ）激酶。
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2.发明授权PETITS ARN INTERFERENTS SPECIFIQUES DES SOUS-UNITES ALPHA, ALPHA' ET ß DE LA PROTEINE KINASE CK2 ET LEURS APPLICATIONS 有权下α，α单位和蛋白激酶CK2特异性siRNA的BETA，以及它们的应用
公开(公告)号：EP1651762B1
公开(公告)日：2013-11-20
申请号：EP04767568.1
申请日：2004-07-02
申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： A61K38/00 , C12N15/11 , C12N15/63 , A61K31/713
CPC分类号： C12N15/1137 , A01K2217/05 , A61K31/713 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12Y207/11001
摘要： The invention relates to small interfering RNA specific to sub-units α, α′ and &bgr; of the kinase protein CK2, and to the applications of the same, especially for treating cancer and viral illnesses.
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3.发明公开PETITS ARN INTERFERENTS SPECIFIQUES DES SOUS-UNITES a, a' ET ß DE LA PROTEINE KINASE CK2 ET LEURS APPLICATIONS 有权下α，α单位和蛋白激酶CK2特异性siRNA的BETA，以及它们的应用
公开(公告)号：EP1651762A2
公开(公告)日：2006-05-03
申请号：EP04767568.1
申请日：2004-07-02
IPC分类号： C12N15/11 , C12N15/63 , A61K31/713
CPC分类号： C12N15/1137 , A01K2217/05 , A61K31/713 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12Y207/11001
摘要： The invention relates to small interfering RNA specific to sub-units α, α' and ß of the kinase protein CK2, and to the applications of the same, especially for treating cancer and viral illnesses.
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公开(公告)号：EP3352794A1
公开(公告)日：2018-08-01
申请号：EP16775552.9
申请日：2016-09-21
申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： GIACOSA, Sofia , PILLET, Catherine , COCHET, Claude , FILHOL, Odile , BARETTE, Caroline , SOLEILHAC, Emmanuelle
IPC分类号： A61K45/06 , A61K31/437 , A61K31/4375 , A61K31/5377 , A61P35/00 , A61P35/04
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/4375 , A61K31/4745 , A61K45/06 , A61P35/00 , A61K2300/00
摘要： The present invention pertains to a novel treatment of renal cell carcinoma and other a solid tumors which harbor a VHL inactivation, based on the combination of a first agent inhibiting a protein kinase CK2 (CK2) and a second agent inhibiting an Ataxia Telangiectasia Mutated (ATM) kinase.
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公开(公告)号：EP2102655B1
公开(公告)日：2013-11-06
申请号：EP08701192.0
申请日：2008-01-02
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Commissariat à l'Énergie Atomique et aux Énergies Alternatives
发明人： COCHET, Claude , FILHOL, Odile , LARAMAS, Mathieu
IPC分类号： C07K16/30 , C07K16/40 , G01N33/574
CPC分类号： C07K16/40 , C07K16/3069 , C07K2317/34 , G01N33/57434 , G01N2333/9121
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6.发明公开CONDENSED PYRIDINE DERIVATIVES USEFUL AS POTENT INHIBITORS OF THE PROTEIN KINASE CK2 审中-公开作为有效的蛋白激酶CK2抑制剂有用稠吡啶衍生物
公开(公告)号：EP2459559A1
公开(公告)日：2012-06-06
申请号：EP10754554.3
申请日：2010-07-28
申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives , Institut National de la Santé et de la Recherche Medicale , Institut Curie , Centre National de la Recherche Scientifique (C.N.R.S.)
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P29/00
CPC分类号： C07D471/04
摘要： The invention relates to the use of specific compounds of formula (I) and their pharmaceutically-acceptable salts:(Formula 1) (I) as a new family of protein kinase CK2 inhibitors; the invention also relates to the use of compounds of formula (I) for the preparation of pharmaceutical compositions for the prevention and/or treatment of disorders and/or diseases chosen amongst cancers; autoimmune and inflammatory diseases; infectious diseases; diabetes angiogenesis related disorders; retinopathies and cardiac hypertrophy.
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