公开(公告)号：EP2459559A1

公开(公告)日：2012-06-06

申请号：EP10754554.3

申请日：2010-07-28

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Institut National de la Santé et de la Recherche Medicale ,  Institut Curie ,  Centre National de la Recherche Scientifique (C.N.R.S.)

发明人： COCHET, Claude ,  PRUDENT, Renaud ,  MOUCADEL, Virginie ,  N'GUYEN, Chi-Hung

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D471/04

摘要： The invention relates to the use of specific compounds of formula (I) and their pharmaceutically-acceptable salts:(Formula 1) (I) as a new family of protein kinase CK2 inhibitors; the invention also relates to the use of compounds of formula (I) for the preparation of pharmaceutical compositions for the prevention and/or treatment of disorders and/or diseases chosen amongst cancers; autoimmune and inflammatory diseases; infectious diseases; diabetes angiogenesis related disorders; retinopathies and cardiac hypertrophy.

公开(公告)号：EP2398799A2

公开(公告)日：2011-12-28

申请号：EP10712497.6

申请日：2010-02-19

申请人： Centre National De La Recherche Scientifique ,  Institut Curie ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： LAFANECHERE, Laurence ,  VASSAL, Emilie ,  BARETTE, Caroline ,  NGUYEN, ChiHung ,  RIVALE, Christian ,  PRUDENT, Renaud

IPC分类号： C07D471/04 ,  A61K31/475 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The present invention relates to the use of pyridocarbazole-type compounds corresponding to the general formula (I) below: (I) as a medicament, and more particularly to the application thereof in anticancer chemotherapy. Another subject of the present invention is specific compounds of formula (I), and also pharmaceutical compositions comprising the compounds of formula (I) of the invention. Finally, the present invention relates to the use of the compounds of formula (I) for the preparation of a medicament intended for preventing and/or treating neurodegenerative-type pathologies, such as Alzheimer's disease and schizophrenia, for the preparation of a medicament intended for preventing and/or treating parasitoses, such as malaria, or for the preparation of a medicament intended for preventing and/or treating glaucomas.

摘要翻译： 本发明涉及对应于以下通式（I）的吡啶并咔唑类化合物的用途：（I）作为药物，更具体地涉及其在抗癌化疗中的应用。 本发明的另一个主题是具体的式（I）化合物，以及包含本发明式（I）化合物的药物组合物。 最后，本发明涉及式（I）化合物在制备用于预防和/或治疗神经退行性病症如阿尔茨海默病和精神分裂症的药物中的用途，所述药物用于制备旨在用于 预防和/或治疗寄生虫病如疟疾，或用于制备预防和/或治疗青光眼的药物。