专利检索 ap:("Commissariat à l'Énergie Atomique et aux Énergies Alternatives" OR "Institut National de la Santé et de la Recherche Medicale" OR "Institut Curie" OR "Centre National de la Recherche Scientifique (C.N.R.S.)") AND inv:"N'GUYEN, Chi-Hung" 第 1 页

1.

发明公开
CONDENSED PYRIDINE DERIVATIVES USEFUL AS POTENT INHIBITORS OF THE PROTEIN KINASE CK2 审中-公开
标题翻译：作为有效的蛋白激酶CK2抑制剂有用稠吡啶衍生物

公开(公告)号：EP2459559A1

公开(公告)日：2012-06-06

申请号：EP10754554.3

申请日：2010-07-28

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives , Institut National de la Santé et de la Recherche Medicale , Institut Curie , Centre National de la Recherche Scientifique (C.N.R.S.)

发明人： COCHET, Claude , PRUDENT, Renaud , MOUCADEL, Virginie , N'GUYEN, Chi-Hung

IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P29/00

CPC分类号： C07D471/04

摘要： The invention relates to the use of specific compounds of formula (I) and their pharmaceutically-acceptable salts:(Formula 1) (I) as a new family of protein kinase CK2 inhibitors; the invention also relates to the use of compounds of formula (I) for the preparation of pharmaceutical compositions for the prevention and/or treatment of disorders and/or diseases chosen amongst cancers; autoimmune and inflammatory diseases; infectious diseases; diabetes angiogenesis related disorders; retinopathies and cardiac hypertrophy.

2.

发明公开
UTILISATION D'ISOQUINOLONES POUR LA PREPARATION DE MEDICAMENTS, NOUVELLES ISOQUINOLONES ET LEUR PROCEDE DE SYNTHESE 有权
标题翻译：异喹啉酮的药物，新异喹啉酮和方法用于合成生产中使用

公开(公告)号：EP2542239A1

公开(公告)日：2013-01-09

申请号：EP11712950.2

申请日：2011-03-01

申请人： Université Joseph Fourier , Centre National de la Recherche Scientifique , Institut Curie

发明人： POPOV, Andrei , JUHEM, Aurélie , FLORENT, Jean-Claude , N'GUYEN, Chi-Hung

IPC分类号： A61K31/4375 , A61K31/4704 , A61K31/4709 , C07D217/22 , C07D217/24 , C07D215/233 , A61P35/00

CPC分类号： C07D217/24 , A61K31/337 , A61K31/4375 , A61K31/4704 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/5377 , A61K31/695 , C07D215/233 , C07D217/22 , C07D401/04 , C07D413/04 , C07F7/10

摘要： The invention relates to the use of isoquinolones for preparing drugs, including novel isoquinolones. The invention also relates to said novel isoquinolones as well as to the method for synthesising same. In particular, the invention relates to isoquinolone derivatives used in the treatment of pathological angiogeneses, specifically cancer.

3.

发明授权
UTILISATION D'ISOQUINOLONES POUR LA PREPARATION DE MEDICAMENTS, NOUVELLES ISOQUINOLONES ET LEUR PROCEDE DE SYNTHESE 有权
标题翻译：异喹啉酮的药物，新异喹啉酮和方法用于合成生产中使用

公开(公告)号：EP2542239B1

公开(公告)日：2015-11-11

申请号：EP11712950.2

申请日：2011-03-01

申请人： Université Joseph Fourier , Centre National de la Recherche Scientifique , Institut Curie

发明人： POPOV, Andrei , JUHEM, Aurélie , FLORENT, Jean-Claude , N'GUYEN, Chi-Hung

IPC分类号： A61K31/4375 , A61K31/4704 , A61K31/4709 , C07D217/22 , C07D217/24 , C07D215/233 , A61P35/00

CPC分类号： C07D217/24 , A61K31/337 , A61K31/4375 , A61K31/4704 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/5377 , A61K31/695 , C07D215/233 , C07D217/22 , C07D401/04 , C07D413/04 , C07F7/10

4.

发明公开
AMINO-SUBSTITUTED-ALKYLOXY-BENZO[E]PYRIDO[4,3-B]INDOLE DERIVATIVES AS NEW POTENT KINASE INHIBITORS 审中-公开
标题翻译：氨基烷氧基苯并[e] [4,3-B] INDOLDERIVATIVE AS一种新的有效激酶抑制剂

公开(公告)号：EP2714689A1

公开(公告)日：2014-04-09

申请号：EP12729032.8

申请日：2012-05-30

申请人： Institut Curie , Centre National de la Recherche Scientifique (CNRS) , INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： N'GUYEN, Chi-Hung , MOLLA, Annie , LE, Ly-Thuy-Tram

IPC分类号： C07D471/04 , A61P35/00 , A61P29/00 , A61K31/437

CPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K45/06

摘要： The present invention relates to a new class of benzo[e]pyrido-indole, the amino-substituted-alkyloxy-benzo[e]pyrido[4,3-b]indole derivatives, having a particular kinase inhibition profile and useful as a therapeutic agent, in particular an anti-tumoral agent.