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1.发明公开Dissolution of oxidized cellulose and particle preparation by dispersion and neutralization 有权氧化纤维素和粒子产生的通过分散和中和分辨率
公开(公告)号：EP2679601A1
公开(公告)日：2014-01-01
申请号：EP13174367.6
申请日：2013-06-28
发明人： Tramontano, Valentino , Ohri, Rachit , Costa, Daniel S. , Kennedy, Joshua , Farooqi, Sajida , Blaskovich, Philip
IPC分类号： C08B1/00
摘要： A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one neutralizing agent to form a plurality of modified cellulose particles.
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2.发明公开Mitigating thrombus formation on medical devices by influencing ph microenvironment near the surface 审中-公开通过影响表面附近的pH值微环境在医疗装置上的血栓形成的弱化
公开(公告)号：EP2380607A3
公开(公告)日：2011-12-28
申请号：EP11250308.1
申请日：2011-03-15
CPC分类号： A61L33/064 , C08L33/10
摘要： The present disclosure provides treatments of medical devices which inhibit thrombus formation. At least a portion of a substrate of a medical device includes a surface possessing a functionality and / or surface charge adapted to modulate the pH of the surface of the medical device, as well as the pH microenvironment near the surface of a medical device.
摘要翻译： 本发明提供抑制血栓形成的医疗设备的处理。 至少一个医疗装置的一个基板的一部分包括一个表面波塞唱上和/或表面电荷angepasst一个函数来调节所述医疗装置的表面的pH值，以及将pH微环境的医疗装置的表面附近。
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公开(公告)号：EP2679253A2
公开(公告)日：2014-01-01
申请号：EP13174415.3
申请日：2013-06-28
摘要： A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
摘要翻译： 溶解改性纤维素的方法包括将改性纤维素与溶剂在混合物中接触以形成溶胀的改性纤维素，然后使该混合物与盐接触以溶解溶胀的改性纤维素。 溶解的改性纤维素用于形成可预测降解的涂层，膜或纤维中的至少一种。
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4.发明公开Modulating drug release rate by controlling the kinetics of the pH transition in hydrogels 审中-公开通过控制在所述水凝胶的pH转变的动力学调节药物释放速率
公开(公告)号：EP2386290A3
公开(公告)日：2013-12-18
申请号：EP11250311.5
申请日：2011-03-15
CPC分类号： A61K9/06 , A61K9/0014 , A61K47/32
摘要： Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed.
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公开(公告)号：EP2481426B1
公开(公告)日：2017-06-28
申请号：EP12152996.0
申请日：2012-01-30
IPC分类号： A61K47/60
CPC分类号： C07C231/02 , A61K47/30 , A61K47/48215 , A61K47/48784 , A61K47/60 , A61K47/6903 , C07D207/46 , C08G65/00 , Y10T428/31551
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6.发明公开Dissolution of oxidized cellulose and particle preparation by solvent and non-solvent precipitation 有权氧化纤维素和颗粒生产由溶剂和非溶剂沉淀分辨率
公开(公告)号：EP2679603A1
公开(公告)日：2014-01-01
申请号：EP13174412.0
申请日：2013-06-28
发明人： Tramontano, Valentino , Blaskovich, Philip , Ohri, Rachit , Kennedy, Joshua , Farooqi, Sajida , Costa, Daniel S.
IPC分类号： C08B1/00
CPC分类号： C08B1/003 , C08B15/00 , C08B15/005 , C08B15/02 , C08J3/096 , C08J3/14 , C08J2301/04
摘要： A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one non-solvent to form a plurality of modified cellulose particles.
摘要翻译： 一种用于溶解改性纤维素过程包括使改性纤维素溶液与至少一种非溶剂中以形成改性纤维素颗粒复数。
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7.发明公开Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations 有权氧化纤维素和粒子产生的通过与多价阳离子交联的分辨率
公开(公告)号：EP2679602A1
公开(公告)日：2014-01-01
申请号：EP13174376.7
申请日：2013-06-28
发明人： Blaskovich, Philip , Tramontano, Valentino , Ohri, Rachit , Costa, Daniel S. , Kennedy, Joshua , Farooqi, Sajida
IPC分类号： C08B1/00
CPC分类号： C08B1/003 , C08B15/00 , C08B15/005 , C08B15/02 , C08J3/075 , C08J3/096 , C08J3/14 , C08J2301/04 , C08L1/04
摘要： A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
摘要翻译： 一种用于溶解改性纤维素过程包括使改性纤维素溶液与至少一种多价阳离子，以形成改性的纤维素颗粒的复数。
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公开(公告)号：EP2668943A1
公开(公告)日：2013-12-04
申请号：EP13170166.6
申请日：2013-05-31
CPC分类号： A61K9/4866 , A61K9/1647 , A61K9/1652 , A61K9/1694 , A61K9/5031 , A61K9/5089 , A61L15/28 , A61L15/44 , A61L27/20 , A61L27/54 , A61L2300/60 , C08L1/02
摘要： A process for forming microspheres is disclosed. The process includes: forming a first plurality microspheres comprising at least one bioactive agent and modified cellulose; contacting the first plurality of microspheres with a solution of a biodegradable polymer to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres comprising the first plurality of microspheres.
摘要翻译： 公开了一种形成微球体的方法。 该方法包括：形成包含至少一种生物活性剂和改性纤维素的第一多个微球体; 使第一多个微球体与生物可降解聚合物的溶液接触以形成不连续相液体; 使不连续相液体与连续相液体接触以形成乳液; 以及从所述乳液中提取第二多个微球体，所述第二多个微球体包含所述第一多个微球体。
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公开(公告)号：EP2468255B1
公开(公告)日：2018-01-31
申请号：EP11194491.4
申请日：2011-12-20
CPC分类号： A61K9/0004 , A61K9/0024
摘要： The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
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10.发明公开Drug Delivery Implants, Systems and Methods for Making 有权Arzneimittelfreisetzende植入物，系统和Herstellungsverfahren
公开(公告)号：EP2474305A3
公开(公告)日：2014-03-12
申请号：EP12150344.5
申请日：2012-01-06
CPC分类号： A61K9/0024 , A61M37/0069
摘要： The present disclosure provides implants suitable for drug delivery. In embodiments, the present disclosure provides layered biodegradable drug delivery implants and systems and methods for making these implants.
摘要翻译： 本公开提供适于药物递送的植入物。 在实施方案中，本公开提供了分层可生物降解的药物递送植入物以及用于制备这些植入物的系统和方法。
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