公开(公告)号：EP2397164B1

公开(公告)日：2015-04-08

申请号：EP11007569.4

申请日：2008-02-13

申请人： Confluent Surgical Inc.

发明人： Sawhney, Amarpreet S. ,  Bennett, Steven L.

IPC分类号： A61L27/52 ,  A61L27/58

CPC分类号： A61L27/18 ,  A61K47/183 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2430/38 ,  C08G65/33324 ,  C08G2210/00

摘要： Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column.

公开(公告)号：EP2093241A2

公开(公告)日：2009-08-26

申请号：EP09250192.3

申请日：2009-01-26

申请人： Confluent Surgical Inc.

发明人： Bennett, Steven L.

IPC分类号： C08G18/32

CPC分类号： A61L31/148 ,  A61B17/06166 ,  A61B17/0643 ,  A61B17/68 ,  A61B17/846 ,  A61B2017/00004 ,  A61B2017/00889 ,  A61L17/10 ,  A61L27/16 ,  A61L27/58 ,  A61L31/048 ,  C08F283/006 ,  C08F290/067 ,  C08G18/3819 ,  C08G18/4825 ,  C08G18/771 ,  C08G2230/00 ,  C08L53/00 ,  C08L2666/02

摘要： A bioabsorbable polyurethane block copolymer with having hard and soft segments is formed by the reaction between a diisocyanate such as lysine ethyl ester diisocyanate and a mixture of (i) an aromatic amide or an amino acid derivative and (ii) a polyether glycol and/or an absorbable elastomeric polymer derived from the reaction between dialkylene glycol and a cyclic bioabsorbable monomer such as trimethylene carbonate, caprolactone, or dioxanone.

公开(公告)号：EP2380607A3

公开(公告)日：2011-12-28

申请号：EP11250308.1

申请日：2011-03-15

申请人： Confluent Surgical Inc.

发明人： Ohri, Rachit ,  Blaskovich, Philip ,  Bennett, Steven L. ,  Tramontano, Valentino

IPC分类号： A61L33/06 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L33/064 ,  C08L33/10

摘要： The present disclosure provides treatments of medical devices which inhibit thrombus formation. At least a portion of a substrate of a medical device includes a surface possessing a functionality and / or surface charge adapted to modulate the pH of the surface of the medical device, as well as the pH microenvironment near the surface of a medical device.

摘要翻译： 本发明提供抑制血栓形成的医疗设备的处理。 至少一个医疗装置的一个基板的一部分包括一个表面波塞唱上和/或表面电荷angepasst一个函数来调节所述医疗装置的表面的pH值，以及将pH微环境的医疗装置的表面附近。

公开(公告)号：EP1967220A2

公开(公告)日：2008-09-10

申请号：EP08250526.4

申请日：2008-02-13

申请人： Confluent Surgical Inc.

发明人： Sawhney, Amarpreet S. ,  Bennett, Steven L.

IPC分类号： A61L27/52 ,  A61L27/58

CPC分类号： A61L27/18 ,  A61K47/183 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2430/38 ,  C08G65/33324 ,  C08G2210/00

摘要： Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column.

摘要翻译： 本公开的一些方面涉及通过形成原位粘附到脊柱内部的组织并且基本上在脊柱的外部的组织外部的低溶胀的可生物降解的水凝胶来治疗椎骨内的组织的外科治疗。

公开(公告)号：EP2093241A3

公开(公告)日：2012-07-11

申请号：EP09250192.3

申请日：2009-01-26

申请人： Confluent Surgical Inc.

发明人： Bennett, Steven L.

IPC分类号： C08G18/32 ,  A61B17/68 ,  A61L17/10 ,  A61L27/16 ,  A61L27/58 ,  A61L31/04 ,  A61L31/14 ,  C08F283/00 ,  C08F290/06 ,  C08G18/38 ,  C08G18/48 ,  C08G18/77 ,  C08L53/00

CPC分类号： A61L31/148 ,  A61B17/06166 ,  A61B17/0643 ,  A61B17/68 ,  A61B17/846 ,  A61B2017/00004 ,  A61B2017/00889 ,  A61L17/10 ,  A61L27/16 ,  A61L27/58 ,  A61L31/048 ,  C08F283/006 ,  C08F290/067 ,  C08G18/3819 ,  C08G18/4825 ,  C08G18/771 ,  C08G2230/00 ,  C08L53/00 ,  C08L2666/02

摘要： A bioabsorbable polyurethane block copolymer with having hard and soft segments is formed by the reaction between a diisocyanate such as lysine ethyl ester diisocyanate and a mixture of (i) an aromatic amide or an amino acid derivative and (ii) a polyether glycol and/or an absorbable elastomeric polymer derived from the reaction between dialkylene glycol and a cyclic bioabsorbable monomer such as trimethylene carbonate, caprolactone, or dioxanone.

摘要翻译： 通过二异氰酸酯如赖氨酸乙酯二异氰酸酯与（i）芳族酰胺或氨基酸衍生物和（ii）聚醚二醇和/或其混合物的混合物的反应形成具有硬和软链段的生物可吸收聚氨酯嵌段共聚物和/或 衍生自二亚烷基二醇和环状生物可吸收单体如三亚甲基碳酸酯，己内酯或二恶烷酮之间的反应的可吸收的弹性体聚合物。

公开(公告)号：EP2481426B1

公开(公告)日：2017-06-28

申请号：EP12152996.0

申请日：2012-01-30

申请人： Confluent Surgical Inc.

发明人： Ohri, Rachit ,  Blaskovich, Philip ,  Kennedy, Joshua ,  Bennett, Steven L. ,  Driscoll, Arthur

IPC分类号： A61K47/60

CPC分类号： C07C231/02 ,  A61K47/30 ,  A61K47/48215 ,  A61K47/48784 ,  A61K47/60 ,  A61K47/6903 ,  C07D207/46 ,  C08G65/00 ,  Y10T428/31551

公开(公告)号：EP1967220A3

公开(公告)日：2009-01-28

申请号：EP08250526.4

申请日：2008-02-13

申请人： Confluent Surgical Inc.

发明人： Sawhney, Amarpreet S. ,  Bennett, Steven L.

IPC分类号： A61L27/52 ,  A61L27/58 ,  A61L15/60

CPC分类号： A61L27/18 ,  A61K47/183 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2430/38 ,  C08G65/33324 ,  C08G2210/00

摘要： Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column.

公开(公告)号：EP2397164A1

公开(公告)日：2011-12-21

申请号：EP11007569.4

申请日：2008-02-13

申请人： Confluent Surgical Inc.

发明人： Sawhney, Amarpreet S. ,  Bennett, Steven L.

IPC分类号： A61L27/52 ,  A61L27/58 ,  A61L15/60

CPC分类号： A61L27/18 ,  A61K47/183 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2430/38 ,  C08G65/33324 ,  C08G2210/00

摘要： A composition comprising: a first synthetic precursor possessing first functional groups and having a molecular weight of from 100 to 1500 Da, a second synthetic precursor comprising a multi-armed precursor possessing a core and from 3 to 12 arms, the arms each comprising a polyethylene glycol having a molecular weight from 250 to 3000 Da and possessing second functional groups at the ends thereof; wherein the first functional groups crosslink with the second functional groups thereby forming a biodegradable hydrogel which swells from -50% to 50%, for use in the treatment of tissue inside the vertebral column of a patient.

摘要翻译： 一种组合物，其包含：具有第一官能团并具有100至1500Da分子量的第一合成前体，第二合成前体，其包含具有核心和3至12个臂的多臂前体，所述臂各自包含聚乙烯 二醇，其分子量为250〜3000Da，末​​端具有第二官能团; 其中所述第一官能团与所述第二官能团交联，从而形成从-50％至50％膨胀的可生物降解的水凝胶，用于治疗患者脊柱内部的组织。

公开(公告)号：EP2380607A2

公开(公告)日：2011-10-26

申请号：EP11250308.1

申请日：2011-03-15

申请人： Confluent Surgical Inc.

发明人： Ohri, Rachit ,  Blaskovich, Philip ,  Bennett, Steven L. ,  Tramontano, Valentino

IPC分类号： A61L33/06

CPC分类号： A61L33/064 ,  C08L33/10

摘要： The present disclosure provides treatments of medical devices which inhibit thrombus formation. At least a portion of a substrate of a medical device includes a surface possessing a functionality and / or surface charge adapted to modulate the pH of the surface of the medical device, as well as the pH microenvironment near the surface of a medical device.

摘要翻译： 本公开提供了抑制血栓形成的医疗装置的治疗。 医疗装置的基底的至少一部分包括具有适于调节医疗装置的表面的pH以及医疗装置的表面附近的pH微环境的功能性和/或表面电荷的表面。

公开(公告)号：EP2233161A2

公开(公告)日：2010-09-29

申请号：EP10250605.2

申请日：2010-03-26

申请人： Confluent Surgical Inc.

发明人： Bennett, Steven L.

IPC分类号： A61L27/18 ,  A61L27/52

CPC分类号： A61L27/52 ,  A61L27/18 ,  A61L27/58 ,  C08L71/02

摘要： Some aspects of the present disclosure relate to methods for treating a tissue by forming a low-swelling biodegradable hydrogel in situ adherent to the tissue. In embodiments the hydrogel exhibits negative swelling, i.e., shrinking. Such treatments may be utilized to in cosmetic or reconstructive surgery, in sphincter augmentation, treating nerve inflammation, and the like.