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公开(公告)号：EP4035658A1
公开(公告)日：2022-08-03
申请号：EP21382062.4
申请日：2021-01-27
申请人： Consejo Superior de Investigaciones Científicas (CSIC) , Consorcio Centro de Investigación Biomédica en Red M.P. , Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca , Nanomol Technologies, S.L. , Leanbio
发明人： VENTOSA RULL, Leonor , VECINA MIRÓ, Jaume , ROYO EXPOSITO, Miriam , TOMSEN MELERO, Judit , ABASOLO OLAORTUA, Ibane , SCHWARTZ NAVARRO, Simón , CORCHERO NIETO, Jose Luis , PULIDO MARTINEZ, Daniel , CRISTÓBAL LECINA, Edgar , GONZÁLEZ MIRA, Elisabet , SALA VERGÉS, Santiago , CÓRDOBA INSENSÉ, Alba , MERLO MAS, Josep , SOLDEVILA FÀBREGA, Andreu , FONT INGLÉS, Albert
摘要： The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease. It also refers to a process for the production of the liposome.
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公开(公告)号：EP2866839B1
公开(公告)日：2018-08-15
申请号：EP13732179.0
申请日：2013-06-28
申请人： Consejo Superior De Investigaciones Científicas (CSIC) , Fundació Parc Científic de Barcelona , CIBER Centro de Investigación Biomédica en Red , Fundació Institut de Recerca Biomèdica (IRB Barcelona) , Universitat de Barcelona , Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca , Universitat Autònoma de Barcelona
发明人： VENTOSA RULL, Leonor , VECIANA MIRÓ, Jaume , CABRERA PUIG, Ingrid , ELIZONDO SAEZ DE VICUÑA, Elisa , MELGAREJO DIAZ, Marta , ROYO EXPÓSITO, Miriam , ALBERICIO PALOMERA, Fernando , PULIDO MARTINEZ, Daniel , SALA VERGÉS, Santiago , CORCHERO NIETO, Jose Luis , SCHWARTZ NAVARRO, Simón , ABASOLO OLAORTUA, Ibane , VILLAVERDE CORRALES, Antonio Pedro
IPC分类号： A61K47/50
CPC分类号： A61K47/646 , A61K38/47 , A61K47/54 , A61K47/554 , A61K47/60 , A61K47/64 , A61K47/6435 , A61K47/6911 , A61K47/6915 , C12Y302/01022 , Y10T428/2982
摘要： The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.
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3.发明公开FUNCTIONALIZED LIPOSOMES USEFUL FOR THE DELIVERY OF BIOACTIVE COMPOUNDS 有权FUNKTIONALISIERTE LIPOSOME ZUR ABGABE BIOAKTIVER VERBINDUNGEN
公开(公告)号：EP2866839A1
公开(公告)日：2015-05-06
申请号：EP13732179.0
申请日：2013-06-28
申请人： Consejo Superior De Investigaciones Científicas (CSIC) , Fundació Parc Científic de Barcelona , CIBER Centro de Investigación Biomédica en Red , Fundació Institut de Recerca Biomèdica (IRB Barcelona) , Universitat de Barcelona , Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca , Universitat Autònoma De Barcelona
发明人： VENTOSA RULL, Leonor , VECIANA MIRÓ, Jaume , CABRERA PUIG, Ingrid , ELIZONDO SAEZ DE VICUÑA, Elisa , MELGAREJO DIAZ, Marta , ROYO EXPÓSITO, Miriam , ALBERICIO PALOMERA, Fernando , PULIDO MARTINEZ, Daniel , SALA VERGÉS, Santiago , CORCHERO NIETO, Jose Luis , SCHWARTZ NAVARRO, Simón , ABASOLO OLAORTUA, Ibane , VILLAVERDE CORRALES, Antonio Pedro
IPC分类号： A61K47/48
CPC分类号： A61K47/646 , A61K38/47 , A61K47/54 , A61K47/554 , A61K47/60 , A61K47/64 , A61K47/6435 , A61K47/6911 , A61K47/6915 , C12Y302/01022 , Y10T428/2982
摘要： The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.
摘要翻译： 本发明涉及其中固醇通过醚键与引导配体结合的水溶性聚合物官能化的缀合物。 这些缀合物提高其携带囊泡的物理化学和递送性质，使其更稳定，均匀和有效。 还描述了其制备方法，含有所述脂质体的药物组合物及其治疗用途。
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公开(公告)号：EP4284342A1
公开(公告)日：2023-12-06
申请号：EP22702449.4
申请日：2022-01-26
发明人： VENTOSA RULL, Leonor , VECIANA MIRÓ, Jaume , ROYO EXPOSITO, Miriam , TOMSEN MELERO, Judit , ABASOLO OLAORTUA, Ibane , SCHWARTZ NAVARRO, Simón , CORCHERO NIETO, Jose Luis , PULIDO MARTINEZ, Daniel , CRISTÓBAL LECINA, Edgar , GONZÁLEZ MIRA, Elisabet , SALA VERGÉS, Santiago , CÓRDOBA INSENSÉ, Alba , MERLO MAS, Josep , SOLDEVILA FÀBREGA, Andreu , FONT INGLÉS, Albert
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公开(公告)号：EP4244244A1
公开(公告)日：2023-09-20
申请号：EP21802380.2
申请日：2021-11-09
发明人： SAYÓS ORTEGA, Juan , SCHWARTZ NAVARRO, Simón , SERAS FRANZOSO, Joaquin , MARTÍNEZ BARRIOCANAL, Águeda , FERNANDES DE SOUSA RAFAEL, Diana , DA SILVA ANDRADE, Fernanda Raquel
IPC分类号： C07K14/705
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6.发明授权A METHOD FOR DETECTING THE SUSCEPTIBILITY TO DEVELOP ADVERSE SIDE EFFECTS RELATED TO BIOIMPLANTS 有权检测方法的倾向发展与生物植入物相关的副作用
公开(公告)号：EP2564197B1
公开(公告)日：2015-03-18
申请号：EP11715922.8
申请日：2011-04-21
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： C12Q1/6881 , G01N33/56977 , G01N33/6893 , G01N2333/70539 , G01N2800/245
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