公开(公告)号：EP2667886A1

公开(公告)日：2013-12-04

申请号：EP12706686.8

申请日：2012-01-30

申请人： Consiglio Nazionale delle Ricerche ,  Universita' Cattolica Del Sacro Cuore ,  UNIVERSITA DEGLI STUDI DI CAGLIARI ,  Universita' degli Studi di Milano

发明人： CABRAS, Tiziana ,  CASOLI, Claudio ,  CASTAGNOLA, Massimo ,  INZITARI, Rosanna ,  LONGHI, Renato ,  MESSANA, Irene ,  RONZI, Paola ,  VITALI, Alberto

IPC分类号： A61K38/04 ,  A61K38/17 ,  C12N15/11 ,  A61P31/12 ,  A61P31/18 ,  A61P31/10

CPC分类号： C07K14/435 ,  A61K9/0019 ,  A61K38/04 ,  A61K38/17 ,  C07K14/47

摘要： The present invention relates to selected proline-rich peptides of salivary derivation with a strong antiviral activity and also an anti-reservoir activity with respect to the HIV virus, said peptides as medicaments for the treatment, prevention and eradication of HIV on human beings, pharmaceutical compositions comprising at least one of said peptides, pharmaceutical kits comprising at least one of said peptides and therapeutic methods for the treatment, prevention and eradication of HIV on human beings.

摘要翻译： 本发明涉及具有强抗病毒活性的唾液衍生选择的富含脯氨酸的肽，以及相对于HIV病毒的抗储库活性，所述肽作为用于治疗，预防和根除HIV的药物，药物 包含至少一种所述肽的组合物，包含至少一种所述肽的药物试剂盒和用于治疗，预防和根除人的HIV的治疗方法。

公开(公告)号：EP2294422A2

公开(公告)日：2011-03-16

申请号：EP09740956.9

申请日：2009-06-08

申请人： Universita' Cattolica Del Sacro Cuore

发明人： CASTAGNOLA, Massimo ,  MESSANA, Irene ,  INZITARI, Rosanna ,  FANALI, Chiara ,  CABRAS, Tiziana ,  GURRIERI, Fiorella ,  TORRIOLI, Maria, Giulia ,  NERI, Giovanni

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2800/28

摘要： The invention relates to the determination of phosphorylation levels of some specific salivary peptides (statherin, histatin 1, acidic proline-rich proteins, both in whole form (PRP-1 type) and in truncated form (PRP-3 type) as a non-invasive diagnostic marker with a >40% sensitivity for defining autism spectrum disorders (ASDs) patients, methods for performing said determination, a kit for the non-invasive diagnosis of at least 40% of autism cases, containing means for such a determination, and the use of such a determination for therapeutical research on autism.

摘要翻译： 本发明涉及一些特异性唾液肽（statherin，组氨素1，富含酸性脯氨酸的蛋白质，全部形式（PRP-1型）和截短形式（PRP-3型））的磷酸化水平， 用于定义自闭症谱系障碍（ASD）患者> 40％敏感性的侵入性诊断标记，执行所述测定的方法，用于非侵入性诊断至少40％的自闭症病例的试剂盒，其包含用于测定的手段，以及 使用这种自闭症治疗研究的决定。