公开(公告)号：EP2694707A1

公开(公告)日：2014-02-12

申请号：EP12842368.8

申请日：2012-04-09

申请人： Cornell University ,  Purdue Research Foundation ,  Coferon, Inc.

发明人： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald E. ,  GIARDINA, Sarah, Filippa ,  ARNOLD,Lee, Daniel

IPC分类号： C40B30/04 ,  C40B30/06 ,  C40B40/04

CPC分类号： C07D211/26 ,  C07D405/06 ,  C07D409/06 ,  C07D491/107 ,  C07F5/025 ,  C07F5/04

摘要： Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

公开(公告)号：EP2694707B1

公开(公告)日：2018-08-15

申请号：EP12842368.8

申请日：2012-04-09

申请人： Cornell University ,  Purdue Research Foundation

发明人： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald E. ,  GIARDINA, Sarah, Filippa ,  ARNOLD, Lee, Daniel

IPC分类号： C07D409/06 ,  C07D491/107 ,  C07D211/26 ,  C07D405/06 ,  A61K31/422 ,  A61P29/00

CPC分类号： C07D211/26 ,  C07D405/06 ,  C07D409/06 ,  C07D491/107 ,  C07F5/025 ,  C07F5/04

摘要： Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

公开(公告)号：EP2693883B1

公开(公告)日：2018-12-26

申请号：EP12842488.4

申请日：2012-04-09

申请人： Cornell University ,  Purdue Research Foundation

发明人： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald E. ,  GIARDINA, Sarah, F. ,  ARNOLD, Lee, Daniel

IPC分类号： A61K47/55 ,  C07F7/10 ,  A61P11/06 ,  A01N1/00

CPC分类号： A61K31/695 ,  A61K47/55 ,  C07F7/10

摘要： Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.

公开(公告)号：EP2693883A1

公开(公告)日：2014-02-12

申请号：EP12842488.4

申请日：2012-04-09

申请人： Cornell University ,  Purdue Research Foundation ,  Coferon, Inc.

发明人： BARANY, Francis ,  PINGLE, Maneesh ,  BERGSTROM, Donald E. ,  GIARDINA, Sarah, F. ,  ARNOLD, Lee, Daniel

IPC分类号： A01N55/00 ,  A61K31/695

CPC分类号： A61K31/695 ,  A61K47/55 ,  C07F7/10

摘要： Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.