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公开(公告)号：EP2915557B1
公开(公告)日：2018-05-09
申请号：EP13850016.0
申请日：2013-11-01
申请人： Cosmed Pharmaceutical Co., Ltd. , Osaka University , Public University Corporation Nara Medical University
发明人： QUAN, Ying-shu , KAMIYAMA, Fumio , SAITO, Mio , NAKAGAWA, Shinsaku , OKADA, Naoki , HIROBE, Sachiko , ASADA, Hideo
CPC分类号： A61K31/203 , A61K9/0021 , A61K31/122 , A61K31/375 , A61M37/00 , A61M2037/0046 , A61K2300/00
摘要： An object to be achieved by the present invention is to provide a microneedle array which is able to supply effectively retinoic acid to the skin and effective in treating pimples, stains or wrinkles. The retinoic acid microneedle array comprises: a microneedle array having a microneedle substrate 5 and microneedles 1 disposed on the microneedle substrate 5; and a drug retained on the microneedles 1 and containing a water-swelling polymer and retinoic acid.
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公开(公告)号：EP2915557A1
公开(公告)日：2015-09-09
申请号：EP13850016.0
申请日：2013-11-01
申请人： Cosmed Pharmaceutical Co., Ltd. , Osaka University , Public University Corporation Nara Medical University
发明人： QUAN, Ying-shu , KAMIYAMA, Fumio , SAITO, Mio , NAKAGAWA, Shinsaku , OKADA, Naoki , HIROBE, Sachiko , ASADA, Hideo
CPC分类号： A61K31/203 , A61K9/0021 , A61K31/122 , A61K31/375 , A61M37/00 , A61M2037/0046 , A61K2300/00
摘要： An object to be achieved by the present invention is to provide a microneedle array which is able to supply effectively retinoic acid to the skin and effective in treating pimples, stains or wrinkles.
The retinoic acid microneedle array comprises: a microneedle array having a microneedle substrate 5 and microneedles 1 disposed on the microneedle substrate 5; and a drug retained on the microneedles 1 and containing a water-swelling polymer and retinoic acid.摘要翻译： 本发明要实现的目的是提供一种微针阵列，其能够有效地向皮肤提供视黄酸并有效治疗丘疹，斑点或皱纹。 视黄酸微针阵列包括：微针阵列，其具有微针基体5和设置在微针基体5上的微针1; 以及保留在微针1上并含有水溶胀聚合物和视黄酸的药物。
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公开(公告)号：EP4159266A1
公开(公告)日：2023-04-05
申请号：EP21812732.2
申请日：2021-05-24
发明人： QUAN, Ying-shu , LI, Ying-zhe , KAJIYAMA, Kenji , SAITO, Mio , YAMASHITA, Hirofumi , KAMIYAMA, Fumio
IPC分类号： A61M37/00
摘要： Provided is a micro-needle array in which all fine needles can be more easily inserted into the skin regardless of positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array includes: a substrate; and a plurality of micro-needles arranged on one surface of the substrate. Tip parts of the plurality of micro-needles have a height difference, and the micro-needles have a needle length of 80 um or more and 2000 um or less. The height difference of the plurality of micro-needles is preferably based on unevenness of the substrate.
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公开(公告)号：EP3275500B1
公开(公告)日：2020-11-18
申请号：EP15886513.9
申请日：2015-12-10
发明人： QUAN, Ying-shu , LI, Ying-zhe , SAITO, Mio , KITAOKA, Shouta , KAMIYAMA, Fumio
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公开(公告)号：EP3563900A1
公开(公告)日：2019-11-06
申请号：EP17888505.9
申请日：2017-12-28
IPC分类号： A61M37/00
摘要： To provide a practical microneedle preparation which solves a problem that, even if a tip portion of the microneedle could be quantitatively coated with the drug, the drug remained in the stratum corneum when actually applying the microneedle array as a transdermal absorption preparation.
A microneedle array having needles with a length of 350 µm to 900 µm, and a tip apex diameter of 20 µm to 100 µm, including drug-coated portions, and comprising a non-biosoluble polymer as a base, wherein a lower end of each drug-coated portion is 200 µm or more away from a root of the needle.-
公开(公告)号：EP3275500A1
公开(公告)日：2018-01-31
申请号：EP15886513.9
申请日：2015-12-10
发明人： QUAN, Ying-shu , LI, Ying-zhe , SAITO, Mio , KITAOKA, Shouta , KAMIYAMA, Fumio
IPC分类号： A61M37/00
摘要： Provided are a microneedle with excellent performance and a method for manufacturing the microneedle.
A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99 % or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230 - 280 °C, a metal mold temperature of 60 - 130 °C, and an injection pressure of 1000 - 1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21 % or more and an axial contraction rate of tips is 99 % or more.摘要翻译： 本发明提供一种性能优异的微针和微针的制造方法。 其中使用聚乙醇酸作为材料，聚乙醇酸的结晶度为21％以上且尖端的轴向收缩率为99％以上的微针阵列以及聚乙醇酸注射成型于其中的制造方法 筒体温度230〜280℃，金属模具温度60〜130℃，注射压力1000〜1500KPa的条件下进行制造，制造聚乙醇酸的结晶度为21％以上的微针阵列， 尖端的轴向收缩率为99％以上。
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公开(公告)号：EP3412312A1
公开(公告)日：2018-12-12
申请号：EP17747446.7
申请日：2017-02-01
发明人： QUAN, Ying-shu , SAITO, Mio , KITAOKA, Shouta , KAMIYAMA, Fumio
摘要： To provide a composition of a coating liquid for microneedle which is optimal for coating a microneedle with a medicinal ingredient.
The coating liquid for microneedle of the present invention is an aqueous solution containing, as essential components of a base, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide and a surfactant, characterized in that a ratio of the water-soluble polysaccharide to the base is 2 to 60 mass%, and the hardness after being dried is 10 N or more. The coating liquid for microneedle may further contain a water-soluble polyalcohol, and preferably a monosaccharide and/or a disaccharide is 30 to 95 mass%, a surfactant is 0.05 to 5 mass%, and a water-soluble polyalcohol is 10 mass% or less in the base. As the water-soluble polysaccharide, hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable.-
公开(公告)号：EP4389189A1
公开(公告)日：2024-06-26
申请号：EP22858534.5
申请日：2022-08-19
IPC分类号： A61M37/00
CPC分类号： A61M37/00
摘要： Provided is a microneedle array having high bioavailability and pharmacological availability. A microneedle array including a needle portion and a substrate portion, in which the needle portion contains a valuable material in a base containing a water-soluble polymer as a main component, the substrate portion does not contain the valuable material, and the base of the substrate portion contains a water-insoluble polymer as a main component.
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