公开(公告)号：EP3256105A1

公开(公告)日：2017-12-20

申请号：EP16709488.7

申请日：2016-02-09

申请人： Cubic Pharmaceuticals Ltd. ,  Delta Pharmaceuticals Ltd.

发明人： DOUROUMIS, Dennis ,  MANIRUZZAMAN, Mohammed ,  BHATT, Saumil Kiritkumar ,  ALI, Anwar ,  JANGRA, Arun

IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K31/00 ,  B29B9/00

CPC分类号： A61K9/143 ,  A61K9/145 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/00 ,  A61K31/192 ,  B29B9/00 ,  B29B9/06

摘要： A method of producing an extruded, powdered/granulated composition comprising an active pharmaceutical ingredient (API), by the steps of providing an API and a porous inorganic excipient, and processing them by an extrusion process to directly produce an extruded, powdered/granulated composition wherein the API is at least partially absorbed within the pores of the inorganic excipient. In preferred embodiments, the API is melted, or solubilised in a solubilizer.

公开(公告)号：EP3256106A1

公开(公告)日：2017-12-20

申请号：EP16709489.5

申请日：2016-02-09

申请人： Cubic Pharmaceuticals Ltd. ,  Delta Pharmaceuticals Ltd.

发明人： DOUROUMIS, Dennis ,  MANIRUZZAMAN, Mohammed ,  BHATT, Saumil Kiritkumar ,  ALI, Anwar ,  JANGRA, Arun

IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K31/00 ,  B29B9/00

CPC分类号： A61K9/2095 ,  A61J3/10 ,  A61K9/143 ,  A61K9/20 ,  A61K31/00 ,  A61K31/192 ,  A61K33/12 ,  A61K47/32 ,  B29B9/00 ,  B29B9/06 ,  B29C47/0014 ,  B29C47/004

摘要： The present invention relates to a method of producing a direct compression tablet composition comprising the step of processing ibuprofen, a hydrophilic polymer, and an inorganic excipient by an extrusion process to produce an extruded composition in which the ibuprofen forms a solid dispersion/solution within the hydrophilic polymer. The invention is particularly useful in preparing oral dissolvable tablets. Also provided are composition comprising an inorganic excipient and ibuprofen within a hydrophilic polymer.