公开(公告)号：EP1590480A2

公开(公告)日：2005-11-02

申请号：EP03817179.9

申请日：2003-06-04

申请人： Curagen Corporation

发明人： ALSOBROOK, John P., II ,  ANDERSON, David W. ,  BAUMGARTNER, Jason C. ,  BERGHS, Constance ,  BOLDOG, Ferenc L. ,  BURGESS, Catherine E. ,  CASMAN, Stacie J. ,  CATTERTON, Elina ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit R. ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha A. ,  GERLACH, Valerie L. ,  GORMAN, Linda ,  GROSSE, William M. ,  GUNTHER, Erik ,  GUO, Xiaojia ,  GUSEV, Vladimir Y. ,  HERRMANN, John L. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai V. ,  LAROCHELLE, William J. ,  LI, Li ,  LIANG, Hongping ,  LOW, Kenneth ,  MACDOUGALL, John R. ,  MACLACHLAN, Timothy ,  MALYANKAR, Uriel M. ,  MCQUEENEY, Kelly ,  MEZICK, Amanda ,  MILLER, Charles E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John A. ,  QIAN, Xiazhong ,  RASTELLI, Luca ,  RIEGER, Daniel K. ,  ROTHENBERG, Mark E. ,  SHENOY, Suresh G. ,  SHIMKETS, Richard A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly A. ,  STONE, David J. ,  SUKUMARAN, Sujatha ,  SZEKERES, Edward S., Jr. ,  VERNET, Corine A. M. ,  VOSS, Edward Z. ,  WOLENC, Adam R. ,  ZHONG, Mei ,  ZHONG, Haihong

IPC分类号： C12Q1/68 ,  C07H21/04

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.