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公开(公告)号：EP1392865A2
公开(公告)日：2004-03-03
申请号：EP02731269.3
申请日：2002-04-03
申请人： Curagen Corporation
发明人： GUO, Xiaojia , KEKUDA, Ramesh , MILLER, Charles E. , MALYANKAR, Uriel M. , SPYTEK, Kimberly A. , PATTURAJAN, Meera , LIU, Xiaohong , GUSEV, Vladimir Y. , LI, Li , VERNET, Corine A.M. , ZERHUSEN, Bryan D. , GORMAN, Linda , SHENOY, Suresh G. , PENA, Carol E.A. , SMITHSON, Glennda , BURGESS, Catherine E. , GERLACH, Valerie , PADIGARU, Muralidhara , SHIMKETS, Richard A. , GANGOLLI, Esha A. , TAUPIER, Raymond J.,Jr. , CASMAN, Stacie J. , JI, Weizhen , ANDERSON, David W. , LEITE, Mario W. , RASTELLI, Luca , EDINGER, Shlomit R. , STONE, David J. , MACDOUGALL, John R. , ROTHENBERG, Mark E. , MAZUR, Ann , MILLET, Isabelle , PEYMAN, John A. , ELLERMAN, Karen
CPC分类号： C12N15/113 , C07K14/47 , C07K14/5421 , C07K14/705 , C07K14/82 , C12N9/1051 , C12N9/1211 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12Y204/0115
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.
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2.发明公开
公开(公告)号：EP1487864A2
公开(公告)日：2004-12-22
申请号：EP02807660.2
申请日：2002-08-02
申请人： Curagen Corporation
发明人： ANDERSON, David W. , BOLDOG, Ferenc L. , CASMAN, Stacie J. , EDINGER, Shlomit R. , GANGOLLI, Esha A. , GERLACH, Valerie L. , GORMAN, linda , GUO, Xiaojia , KHRAMTSOV, Nikolai V. , LI, Li , MACDOUGALL, John R. , PENA, Carol E. A. , PEYMAN, John A. , PATTURAJAN, Meera , SHIMKETS, Richard A. , SMITHSON, Glennda , SPYTEK, Kimberly A. , VERNET, Corine A M. , VOSS, Edward Z. , ZHONG, Mei
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码G偶联蛋白质受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体，以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。
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3.发明公开
公开(公告)号：EP1576086A2
公开(公告)日：2005-09-21
申请号：EP02773310.4
申请日：2002-09-09
申请人： Curagen Corporation
发明人： ZHONG, Mei , LI, Li , GORMAN, Linda , SPYTEK, Kimberly A. , KEKUDA, Ramesh , TAUPIER, Raymond J., Jr. , ANDERSON, David W. , VERNET, Corine A. M. , CATTERTON, Elina , MILLER, Charles E. , SHENOY, Suresh G. , PATTURAJAN, Meera , PENA, Carol E. A. , TCHERNEV, Velizar T. , PADIGARU, Muralidhara , GUSEV, Vladimir Y. , MALYANKAR, Uriel M. , BURGESS, Catherine E. , GERLACH, Valerie L. , CASMAN, Stacie J. , RIEGER, Daniel K. , GROSSE, William M. , SMITHSON, Glennda , PEYMAN, John A. , STARLING, Gary , ROTHENBERG, Mark E. , LAROCHELLE, William J. , SHIMKETS, Richard A. , CRABTREE, Julie , RASTELLI, Luca , VOSS, Edward Z. , BOLDOG, Ferenc L. , EDINGER, Shlomit R. , MILLET, Isabelle , MACDOUGALL, John R. , ELLERMAN, Karen , CHAPOVAL, Andrei
IPC分类号： C12N1/00
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽特异的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 还包括载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法。 本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。
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4.发明公开THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING THE SAME, AND METHODS OF USE 审中-公开治疗性多肽，编码该核酸的核酸及使用方法
公开(公告)号：EP1539806A2
公开(公告)日：2005-06-15
申请号：EP02741692.4
申请日：2002-05-02
申请人： Curagen Corporation
发明人： ALSOBROOK, John P. II , ANDERSON, David W. , BOLDOG, Ferenc L. , BURGESS, Catherine E. , CASMAN, Stacie J. , EDINGER, Schlomit R. , ELLERMAN, Karen , GANGOLLI, Esha A. , GERLACH, Valerie L. , GORMAN, Linda , GUNTHER, Erik , HERRMANN, John L. , JI, Weizhen , LEPLEY, Denise M. , LEWIN, David A. , LI, Li , MACDOUGALL, John R. , MALYANKAR, Uriel M. , MEZES, Peter D. , PADIGARU, Muralidhara , PATTURAJAN, Meera , PEYMAN, John A. , RASTELLI, Luca , RIEGER, Daniel K. , ROTHENBERG, Mark E. , SHENOY, Suresh G. , SMITHSON, Glennda , SPYTEK, Kimberly A. , STONE, David J. , TAUPIER, Raymond J., Jr. , TCHERNEV, Velizar T. , VERNET, Corine A. M. , VOSS, Edward Z. , ZERHUSEN, Bryan D. , ZHONG, Haihong , MILLER, Charles E.
CPC分类号： C07K14/705 , C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the-polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码G偶联蛋白质受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。
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5.发明公开
公开(公告)号：EP1576086A3
公开(公告)日：2005-12-21
申请号：EP02773310.4
申请日：2002-09-09
申请人： Curagen Corporation
发明人： ZHONG, Mei , LI, Li , GORMAN, Linda , SPYTEK, Kimberly A. , KEKUDA, Ramesh , TAUPIER, Raymond J., Jr. , ANDERSON, David W. , VERNET, Corine A. M. , CATTERTON, Elina , MILLER, Charles E. , SHENOY, Suresh G. , PATTURAJAN, Meera , PENA, Carol E. A. , TCHERNEV, Velizar T. , PADIGARU, Muralidhara , GUSEV, Vladimir Y. , MALYANKAR, Uriel M. , BURGESS, Catherine E. , GERLACH, Valerie L. , CASMAN, Stacie J. , RIEGER, Daniel K. , GROSSE, William M. , SMITHSON, Glennda , PEYMAN, John A. , STARLING, Gary , ROTHENBERG, Mark E. , LAROCHELLE, William J. , SHIMKETS, Richard A. , CRABTREE, Julie , RASTELLI, Luca , VOSS, Edward Z. , BOLDOG, Ferenc L. , EDINGER, Shlomit R. , MILLET, Isabelle , MACDOUGALL, John R. , ELLERMAN, Karen , CHAPOVAL, Andrei
IPC分类号： C12N1/00
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公开(公告)号：EP1581616A2
公开(公告)日：2005-10-05
申请号：EP03707305.3
申请日：2003-01-06
申请人： Curagen Corporation
发明人： ANDERSON, David W. , BALLINGER, Robert A. , BAUMGARTNER, Jason C. , BURGESS, Catherine E. , CASMAN, Stacie J. , CHANT, John S. , BERGHS, Constance , GANGOLLI, Esha A. , EDINGER, Shlomit R. , ELLERMAN, Karen , FURTAK, Katarzyna , GERLACH, Valerie L. , GILBERT, Jennifer A. , GUNTHER, Erik , GORMAN, Linda , GUO, Xiaojia , JI, Weizhen , LI, Li , LIU, Xiaohong , MILLER, Charles E. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , RASTELLI, Luca , MACDOUGALL, John R. , MISHRA, Vishnu S. , PENA, Carol E.A. , SPADERNA, Steven K. , SHIMKETS, Richard A. , SMITHSON, Glennda , SPYTEK, Kimberly A. , STONE, David J. , SHENOY, Suresh G. , ORT, Tatiana , TAUPIER, Raymond J., Jr. , TCHERNEV, Velizar T. , VERNET, Corine A. , WOLENC, Adam R. , ZERHUSEN, Bryan D. , ZHONG, Mei
IPC分类号： C12N1/00
CPC分类号： C12N15/113 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/5421 , C07K14/705 , C07K14/82 , C12N9/1051 , C12N9/1211 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12Y204/0115
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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7.发明公开NOVEL ANTIBODIES THAT BIND TO ANTIGENIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING THE ANTIGENS, AND METHOD OF USE 审中-公开WHAT抗体与抗原多肽结合NUCLEIC其中所述的抗原代码，使用方法
公开(公告)号：EP1390057A2
公开(公告)日：2004-02-25
申请号：EP02763906.1
申请日：2002-04-03
申请人： Curagen Corporation
发明人： PADIGARU, Muralidhara , SHENOY, Suresh, G. , KEKUDA, Ramesh , RASTELLI, Luca , MEZES, Peter, S. , SMITHSON, Glennda , GUO, Xiaojia , GERLACH, Valerie , CASMAN, Stacie, J. , BOLDOG, Ferenc, L. , LI, Li , ZERHUSEN, Bryan, D. , TCHERNEV, Velizar, T. , GANGOLLI, Esha, A. , VERNET, Corine, A., M. , SPYTEK, Kimberly, A. , MALYANKAR, Uriel M. , PATTURAJAN, Meera , MILLER, Charles, E. , TAUPIER, Raymond J., Jr. , HEYES, Melvyn P. , JU, Jingfang , PEYMAN, John A. , CATTERTON, Elina , MACDOUGALL, John R. , EDINGER, Shlomit R. , STONE, David J. , MAZUR, Ann
IPC分类号： A61K38/16
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12Y204/0115
摘要： Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
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公开(公告)号：EP1590480A2
公开(公告)日：2005-11-02
申请号：EP03817179.9
申请日：2003-06-04
申请人： Curagen Corporation
发明人： ALSOBROOK, John P., II , ANDERSON, David W. , BAUMGARTNER, Jason C. , BERGHS, Constance , BOLDOG, Ferenc L. , BURGESS, Catherine E. , CASMAN, Stacie J. , CATTERTON, Elina , DHANABAL, Mohanraj , EDINGER, Shlomit R. , ELLERMAN, Karen , ETTENBERG, Seth , GANGOLLI, Esha A. , GERLACH, Valerie L. , GORMAN, Linda , GROSSE, William M. , GUNTHER, Erik , GUO, Xiaojia , GUSEV, Vladimir Y. , HERRMANN, John L. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai V. , LAROCHELLE, William J. , LI, Li , LIANG, Hongping , LOW, Kenneth , MACDOUGALL, John R. , MACLACHLAN, Timothy , MALYANKAR, Uriel M. , MCQUEENEY, Kelly , MEZICK, Amanda , MILLER, Charles E. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , PEYMAN, John A. , QIAN, Xiazhong , RASTELLI, Luca , RIEGER, Daniel K. , ROTHENBERG, Mark E. , SHENOY, Suresh G. , SHIMKETS, Richard A. , SMITHSON, Glennda , SPYTEK, Kimberly A. , STONE, David J. , SUKUMARAN, Sujatha , SZEKERES, Edward S., Jr. , VERNET, Corine A. M. , VOSS, Edward Z. , WOLENC, Adam R. , ZHONG, Mei , ZHONG, Haihong
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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9.发明公开
公开(公告)号：EP1576146A2
公开(公告)日：2005-09-21
申请号：EP03817177.3
申请日：2003-06-03
申请人： Curagen Corporation
发明人： ALSOBROOK, John P., II , ALVAREZ, Enrique , ANDERSON, David W. , BOLDOG, Ferenc L. , CASMAN, Stacie J. , CATTERTON, Elina , CHAPOVAL, Andrei , CRABTREE-BOKOR, Julie R. , EDINGER, Shlomit R. , ELLERMAN, Karen , ETTENBERG, Seth , GANGOLLI, Esha A. , GERLACH, Valerie L. , GORMAN, Linda , GUNTHER, Erik , GUO, Xiaojia , GUSEV, Vladimir Y. , HERRMANN, John L. , JI, Weizhen , KEKUDA, Ramesh , LI, Li , LIU, Xiaohong , MACDOUGALL, John R. , MACLACHLAN, Timothy , MALYANKAR, Uriel M. , MEZICK, Amanda J. , MILLET, Isabelle , MISHRA, Vishnu S. , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol E. A. , PEYMAN, John A. , RAHA, Debasish , RASTELLI, Luca , RIEGER, Daniel K. , ROTHENBERG, Mark E. , SCIORE, Paul , SHENOY, Suresh G. , SHIMKETS, Richard A. , SMITHSON, Glennda , SPYTEK, Kimberly A. , STONE, David J. , VERNET, Corine A.M. , VOSS, Edward Z. , ZHONG, Mei , ZHONG, Haihong
IPC分类号： C12N1/00
CPC分类号： C12N1/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽具有特异性的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 还包括载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法。 本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。
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公开(公告)号：EP1354042A2
公开(公告)日：2003-10-22
申请号：EP01999178.5
申请日：2001-12-31
申请人： Curagen Corporation
发明人： SPYTEK, Kimberly, A. , LI, Li , WOLENC, Adam, R. , VERNET, Corine, A., M. , EISEN, Andrew , LIU, Xiaohong , MALYANKAR, Uriel , SHIMKETS, Richard, A. , TCHERNEV, Velizar, T. , SPADERNA, Steven, K. , GORMAN, Linda , KEKUDA, Ramesh , PATTURAJAN, Meera , GUSEV, Vladimir , GANGOLLI, Esha, A. , GUO, Xiaojia , SHENOY, Suresh , RASTELLI, Luca , CASMAN, Stacie, J. , BOLDOG, Ferenc , BURGESS, Catherine E. , EDINGER, Shlomit , ELLERMAN, Karen , GUNTHER, Erik , SMITHSON, Glennda , MILLET, Isabelle , MACDOUGALL, John R.
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00
摘要： Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recobinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
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