公开(公告)号：EP1576086A3

公开(公告)日：2005-12-21

申请号：EP02773310.4

申请日：2002-09-09

申请人： Curagen Corporation

发明人： ZHONG, Mei ,  LI, Li ,  GORMAN, Linda ,  SPYTEK, Kimberly A. ,  KEKUDA, Ramesh ,  TAUPIER, Raymond J., Jr. ,  ANDERSON, David W. ,  VERNET, Corine A. M. ,  CATTERTON, Elina ,  MILLER, Charles E. ,  SHENOY, Suresh G. ,  PATTURAJAN, Meera ,  PENA, Carol E. A. ,  TCHERNEV, Velizar T. ,  PADIGARU, Muralidhara ,  GUSEV, Vladimir Y. ,  MALYANKAR, Uriel M. ,  BURGESS, Catherine E. ,  GERLACH, Valerie L. ,  CASMAN, Stacie J. ,  RIEGER, Daniel K. ,  GROSSE, William M. ,  SMITHSON, Glennda ,  PEYMAN, John A. ,  STARLING, Gary ,  ROTHENBERG, Mark E. ,  LAROCHELLE, William J. ,  SHIMKETS, Richard A. ,  CRABTREE, Julie ,  RASTELLI, Luca ,  VOSS, Edward Z. ,  BOLDOG, Ferenc L. ,  EDINGER, Shlomit R. ,  MILLET, Isabelle ,  MACDOUGALL, John R. ,  ELLERMAN, Karen ,  CHAPOVAL, Andrei

IPC分类号： C12N1/00

公开(公告)号：EP1581616A2

公开(公告)日：2005-10-05

申请号：EP03707305.3

申请日：2003-01-06

申请人： Curagen Corporation

发明人： ANDERSON, David W. ,  BALLINGER, Robert A. ,  BAUMGARTNER, Jason C. ,  BURGESS, Catherine E. ,  CASMAN, Stacie J. ,  CHANT, John S. ,  BERGHS, Constance ,  GANGOLLI, Esha A. ,  EDINGER, Shlomit R. ,  ELLERMAN, Karen ,  FURTAK, Katarzyna ,  GERLACH, Valerie L. ,  GILBERT, Jennifer A. ,  GUNTHER, Erik ,  GORMAN, Linda ,  GUO, Xiaojia ,  JI, Weizhen ,  LI, Li ,  LIU, Xiaohong ,  MILLER, Charles E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  RASTELLI, Luca ,  MACDOUGALL, John R. ,  MISHRA, Vishnu S. ,  PENA, Carol E.A. ,  SPADERNA, Steven K. ,  SHIMKETS, Richard A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly A. ,  STONE, David J. ,  SHENOY, Suresh G. ,  ORT, Tatiana ,  TAUPIER, Raymond J., Jr. ,  TCHERNEV, Velizar T. ,  VERNET, Corine A. ,  WOLENC, Adam R. ,  ZERHUSEN, Bryan D. ,  ZHONG, Mei

IPC分类号： C12N1/00

CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/5421 ,  C07K14/705 ,  C07K14/82 ,  C12N9/1051 ,  C12N9/1211 ,  C12N15/1135 ,  C12N15/1137 ,  C12N15/1138 ,  C12Y204/0115

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：EP1572995A3

公开(公告)日：2005-12-14

申请号：EP02792183.2

申请日：2002-10-02

申请人： Curagen Corporation

发明人： SMITHSON, Glennda ,  MILLET, Isabelle ,  PEYMAN, John A. ,  KEKUDA, Ramesh ,  JU, Jingfang ,  LI, Li ,  GUO, Xiaojia ,  PATTURAJAN, Meera ,  SPYTEK, Kimberly A. ,  EDINGER, Shlomit R. ,  ELLERMAN, Karen ,  MALYANKAR, Uriel M. ,  ORT, Tatiana ,  GORMAN, Linda ,  ZERHUSEN, Bryan D. ,  ANDERSON, David W. ,  ZHONG, Mei ,  CATTERTON, Elina ,  JI, Weizhen ,  MILLER, Charles E. ,  RASTELLI, Luca ,  STONE, David J. ,  PENA, Carol E. A. ,  SHENOY, Suresh G. ,  SHIMKETS, Richard A. ,  ROTHENBERG, Mark E. ,  LEACH, Martin D. ,  AGEE, Michele L. ,  BERGHS, Constance ,  DIPIPPO, Vincent A. ,  EISEN, Andrew ,  GANGOLLI, Esha A. ,  RIEGER, Daniel K. ,  SPADERNA, Steven K.

IPC分类号： C12N9/12 ,  A61K38/00

CPC分类号： C07K14/47 ,  A61K38/00

公开(公告)号：EP1392865A2

公开(公告)日：2004-03-03

申请号：EP02731269.3

申请日：2002-04-03

申请人： Curagen Corporation

发明人： GUO, Xiaojia ,  KEKUDA, Ramesh ,  MILLER, Charles E. ,  MALYANKAR, Uriel M. ,  SPYTEK, Kimberly A. ,  PATTURAJAN, Meera ,  LIU, Xiaohong ,  GUSEV, Vladimir Y. ,  LI, Li ,  VERNET, Corine A.M. ,  ZERHUSEN, Bryan D. ,  GORMAN, Linda ,  SHENOY, Suresh G. ,  PENA, Carol E.A. ,  SMITHSON, Glennda ,  BURGESS, Catherine E. ,  GERLACH, Valerie ,  PADIGARU, Muralidhara ,  SHIMKETS, Richard A. ,  GANGOLLI, Esha A. ,  TAUPIER, Raymond J.,Jr. ,  CASMAN, Stacie J. ,  JI, Weizhen ,  ANDERSON, David W. ,  LEITE, Mario W. ,  RASTELLI, Luca ,  EDINGER, Shlomit R. ,  STONE, David J. ,  MACDOUGALL, John R. ,  ROTHENBERG, Mark E. ,  MAZUR, Ann ,  MILLET, Isabelle ,  PEYMAN, John A. ,  ELLERMAN, Karen

IPC分类号： C12Q1/68 ,  C12N1/20 ,  C12N5/08 ,  A61K38/00 ,  C07H21/04

CPC分类号： C12N15/113 ,  C07K14/47 ,  C07K14/5421 ,  C07K14/705 ,  C07K14/82 ,  C12N9/1051 ,  C12N9/1211 ,  C12N15/1135 ,  C12N15/1137 ,  C12N15/1138 ,  C12Y204/0115

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

公开(公告)号：EP1373526A2

公开(公告)日：2004-01-02

申请号：EP02806909.4

申请日：2002-03-08

申请人： Curagen Corporation

发明人： KEKUDA, Ramesh ,  TCHERNEV, Velizar T. ,  LIU, Xiaohong ,  SPYTEK, Kimberly A. ,  PATTURAJAN, Meera ,  BURGESS, Catherine E. ,  VERNET, Corine A.M. ,  LI, Li ,  GORMAN, Linda ,  MALYANKAR, Uriel M. ,  BOLDOG, Ferenc L. ,  GUO, Xiaojia ,  SHENOY, Suresh G. ,  PADIGARU, Muralidhara ,  TAUPIER, Raymond J., Jr. ,  MILLER, Charles E. ,  CASMAN, Stacie J. ,  PENA, Carol E.A. ,  GANGOLLI, Esha A. ,  GUSEV, Vladimir ,  SMITHSON, Glennda ,  ZERHUSEN, Bryan D. ,  GERLACH, Valerie ,  POCHART, Pascale F.J. ,  FERNANDES, Elma R. ,  SHIMKETS, Richard A. ,  RASTELLI, Luca ,  SPADERNA, Steven K. ,  LAROCHELLE, William J. ,  ZHONG, Mei ,  KHRAMTSOV, Nikolai V. ,  VOSS, Edward Z. ,  HERRMANN, John L.

IPC分类号： C12N15/63 ,  C12N15/12 ,  A61K38/16 ,  C07K14/00

摘要： Diclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclodes therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文中公开了编码G偶联蛋白质受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体突变体或片段。 本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人类核酸和蛋白质的疾病的治疗，诊断和研究方法。

公开(公告)号：EP1578905A2

公开(公告)日：2005-09-28

申请号：EP02765778.2

申请日：2002-06-04

申请人： Curagen Corporation

发明人： AGEE, Michele L. ,  ANDERSON, David W. ,  BERGHS, Constance ,  CASMAN, Stacie J. ,  CATTERTON, Elina ,  DIPIPPO, Vincent A. ,  EDINGER, Shlomit R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha A. ,  GERLACH, Valerie L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  HERRMANN, John L. ,  HJALT, Tord ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai V. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel M. ,  MILLER, Charles E. ,  MILLET, Isabelle ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol E.A. ,  RASTELLI, Luca ,  RIEGER, Daniel K. ,  ROTHENBERG, Mark E. ,  SHENOY, Suresh G. ,  SHIMKETS, Richard A. ,  SMITHSON, Glennda ,  SPADERNA, Steven K. ,  SPYTEK, Kimberly A. ,  STONE, David J. ,  VERNET, Corine A.M. ,  ZHONG, Haihong ,  ZHONG, Mei ,  ALSOBROOK, John P.,II ,  BURGESS, Catherine E. ,  LEPLEY, Denise M.

IPC分类号： C12N1/00

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

摘要翻译： 本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。 公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。

公开(公告)号：EP1572948A2

公开(公告)日：2005-09-14

申请号：EP03754372.5

申请日：2003-06-04

申请人： Curagen Corporation

发明人： ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PRAYAGA, Sudhirdas, K. ,  PATTURAJAN, Meera ,  PENA, Carol E.A. ,  PEYMAN, John A. ,  RIEGER, Daniel K. ,  ROTHENBERG, Mark E. ,  SCIORE, Paul ,  SHENOY, Suresh G. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly A. ,  STONE, David J. ,  TAUPIER, Raymond J., Jr. ,  TSCHERNEV, Velizar T. ,  VERNET, Corine A.M. ,  VOSS, Edward Z. ,  ZERHUSEN, Bryan D. ,  ZHONG, Mei

IPC分类号： C12N1/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：EP1572898A2

公开(公告)日：2005-09-14

申请号：EP02807098.5

申请日：2002-09-09

申请人： Curagen Corporation

发明人： AGEE, Michele L. ,  ALSOBROOK, John P.II ,  ANDERSON, David W. ,  BERGHS, Constance ,  BOLDOG, Ferenc L. ,  BURGESS, Catherine E. ,  CASMAN, Stacie J. ,  CATTERTON, Elina ,  CHANT, John S. ,  CHAUDHURI, Amitabha ,  CRABTREE, Julie ,  DIPIPPO, Vincent A. ,  EDINGER, Shlomit R. ,  EISEN, Andrew J. ,  ELLERMAN, Karen ,  GANGOLLI, Esha A. ,  GERLACH, Valerie L. ,  GIOT, Loic ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir Y. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai ,  LEACH, Martin D. ,  LEPLEY, Denise M. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel M. ,  MILLER, Charles E. ,  OOI, Chean Eng ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol E.A. ,  RIEGER, Daniel K. ,  ROTHENBURG, Mark E. ,  SHENOY, Suresh G. ,  SHIMKETS, Richard A. ,  SPADERNA, Steven K. ,  SPYTEK, Kimberly A. ,  TAUPIER, Raymond J.,jr. ,  TWOMLOW, Nancy ,  VERNET, Corine A.M. ,  VOSS, Edward Z. ,  ZERHUSEN, Bryan D. ,  ZHONG, Mei

IPC分类号： C12N1/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/00

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：EP1590480A2

公开(公告)日：2005-11-02

申请号：EP03817179.9

申请日：2003-06-04

申请人： Curagen Corporation

发明人： ALSOBROOK, John P., II ,  ANDERSON, David W. ,  BAUMGARTNER, Jason C. ,  BERGHS, Constance ,  BOLDOG, Ferenc L. ,  BURGESS, Catherine E. ,  CASMAN, Stacie J. ,  CATTERTON, Elina ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit R. ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha A. ,  GERLACH, Valerie L. ,  GORMAN, Linda ,  GROSSE, William M. ,  GUNTHER, Erik ,  GUO, Xiaojia ,  GUSEV, Vladimir Y. ,  HERRMANN, John L. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai V. ,  LAROCHELLE, William J. ,  LI, Li ,  LIANG, Hongping ,  LOW, Kenneth ,  MACDOUGALL, John R. ,  MACLACHLAN, Timothy ,  MALYANKAR, Uriel M. ,  MCQUEENEY, Kelly ,  MEZICK, Amanda ,  MILLER, Charles E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John A. ,  QIAN, Xiazhong ,  RASTELLI, Luca ,  RIEGER, Daniel K. ,  ROTHENBERG, Mark E. ,  SHENOY, Suresh G. ,  SHIMKETS, Richard A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly A. ,  STONE, David J. ,  SUKUMARAN, Sujatha ,  SZEKERES, Edward S., Jr. ,  VERNET, Corine A. M. ,  VOSS, Edward Z. ,  WOLENC, Adam R. ,  ZHONG, Mei ,  ZHONG, Haihong

IPC分类号： C12Q1/68 ,  C07H21/04

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：EP1576146A2

公开(公告)日：2005-09-21

申请号：EP03817177.3

申请日：2003-06-03

申请人： Curagen Corporation

发明人： ALSOBROOK, John P., II ,  ALVAREZ, Enrique ,  ANDERSON, David W. ,  BOLDOG, Ferenc L. ,  CASMAN, Stacie J. ,  CATTERTON, Elina ,  CHAPOVAL, Andrei ,  CRABTREE-BOKOR, Julie R. ,  EDINGER, Shlomit R. ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha A. ,  GERLACH, Valerie L. ,  GORMAN, Linda ,  GUNTHER, Erik ,  GUO, Xiaojia ,  GUSEV, Vladimir Y. ,  HERRMANN, John L. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  LI, Li ,  LIU, Xiaohong ,  MACDOUGALL, John R. ,  MACLACHLAN, Timothy ,  MALYANKAR, Uriel M. ,  MEZICK, Amanda J. ,  MILLET, Isabelle ,  MISHRA, Vishnu S. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol E. A. ,  PEYMAN, John A. ,  RAHA, Debasish ,  RASTELLI, Luca ,  RIEGER, Daniel K. ,  ROTHENBERG, Mark E. ,  SCIORE, Paul ,  SHENOY, Suresh G. ,  SHIMKETS, Richard A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly A. ,  STONE, David J. ,  VERNET, Corine A.M. ,  VOSS, Edward Z. ,  ZHONG, Mei ,  ZHONG, Haihong

IPC分类号： C12N1/00

CPC分类号： C12N1/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽具有特异性的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 还包括载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法。 本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。