公开(公告)号：EP3766493A1

公开(公告)日：2021-01-20

申请号：EP20193883.4

申请日：2008-04-26

申请人： CyDex Pharmaceuticals, Inc.

发明人： MOSHER, Gerold L. ,  WEDEL, Rebecca L. ,  JOHNSON, Karen T. ,  MACHATHA, Stephen G. ,  COWEE, Jane A. ,  CUSHING, Daniel J.

IPC分类号： A61K31/4365 ,  A61K47/40 ,  A61K47/69 ,  A61K31/44 ,  A61K31/724 ,  A61K31/727 ,  A61K31/737 ,  A61K45/06 ,  A61K9/00 ,  A61K9/08 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/06 ,  A61K9/19 ,  B82Y5/00

摘要： The invention relates to a method of improving the stability of clopidogrel in a composition comprising clopidogrel, the method comprising adding a sulfoalkyl ether cyclodextrin (SAE-CD) of Formula 1:

wherein: n is 4, 5, or 6; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are each, independently, -O- or a -O-(C 2 -C 6 alkylene)-SO 3 - group, wherein at least one of R 1 to R 9 is independently a -O-(C 2 -C 6 alkylene)-SO 3 - group; and S 1 , S 2 , S 3 , S 4 , S 5 , S 6 , S 7 , S 8 , and S 9 are each, independently, a pharmaceutically acceptable cation, to the composition,
wherein the molar ratio of the SAE-CD to the clopidogrel is at least 6:1, when the pH of the formulation is 3.5 or greater.

公开(公告)号：EP3100728B1

公开(公告)日：2019-11-20

申请号：EP16176280.2

申请日：2010-05-13

申请人： Cydex Pharmaceuticals, Inc.

发明人： MOSHER, Gerold ,  MACHATHA, Stephen G. ,  CUSHING, Daniel J.

IPC分类号： A61K31/4365 ,  B82Y5/00