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公开(公告)号：EP4083075A1
公开(公告)日：2022-11-02
申请号：EP22160923.3
申请日：2013-02-14
发明人： MATOS, Jose R. , ANTLE, Vincent D.
IPC分类号： C08B37/16
摘要： A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
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公开(公告)号：EP3766493A1
公开(公告)日：2021-01-20
申请号：EP20193883.4
申请日：2008-04-26
发明人： MOSHER, Gerold L. , WEDEL, Rebecca L. , JOHNSON, Karen T. , MACHATHA, Stephen G. , COWEE, Jane A. , CUSHING, Daniel J.
IPC分类号： A61K31/4365 , A61K47/40 , A61K47/69 , A61K31/44 , A61K31/724 , A61K31/727 , A61K31/737 , A61K45/06 , A61K9/00 , A61K9/08 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/06 , A61K9/19 , B82Y5/00
摘要： The invention relates to a method of improving the stability of clopidogrel in a composition comprising clopidogrel, the method comprising adding a sulfoalkyl ether cyclodextrin (SAE-CD) of Formula 1:
wherein: n is 4, 5, or 6; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are each, independently, -O- or a -O-(C 2 -C 6 alkylene)-SO 3 - group, wherein at least one of R 1 to R 9 is independently a -O-(C 2 -C 6 alkylene)-SO 3 - group; and S 1 , S 2 , S 3 , S 4 , S 5 , S 6 , S 7 , S 8 , and S 9 are each, independently, a pharmaceutically acceptable cation, to the composition,
wherein the molar ratio of the SAE-CD to the clopidogrel is at least 6:1, when the pH of the formulation is 3.5 or greater.-
公开(公告)号：EP3100728B1
公开(公告)日：2019-11-20
申请号：EP16176280.2
申请日：2010-05-13
IPC分类号： A61K31/4365 , B82Y5/00
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4.发明授权PHARMACEUTICAL COMPOSITIONS COMPRISING PRASUGREL AND CYCLODEXTRIN DERIVATIVES AND METHODS OF MAKING AND USING THE SAME 有权药物组合物和PRASUGREL-环糊精衍生物，AND METHOD FOR生产和使用
公开(公告)号：EP2429291B1
公开(公告)日：2016-07-06
申请号：EP10775566.2
申请日：2010-05-13
CPC分类号： A61K31/4365 , A61K9/0019 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0012 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
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5.发明授权
公开(公告)号：EP1945228B2
公开(公告)日：2014-11-05
申请号：EP05856927.8
申请日：2005-10-26
IPC分类号： A61K31/724 , A61K31/715 , A61K47/40 , A61K47/14 , A61K47/20
CPC分类号： C08B37/0012 , A61K9/0056 , A61K9/0075 , A61K9/0095 , A61K9/1652 , A61K9/205 , A61K9/2054 , A61K31/519 , A61K31/53 , A61K31/5415 , A61K31/573 , A61K31/715 , A61K31/724 , A61K45/06 , A61K47/40 , B01D1/18 , Y10T428/2982
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6.发明公开INJECTABLE MELPHALAN COMPOSITIONS COMPRISING A CYCLODEXTRIN DERIVATIVE AND METHODS OF MAKING AND USING THE SAME 有权注射马法兰了包含生产和使用它们的环糊精衍生物和方法
公开(公告)号：EP2434886A4
公开(公告)日：2014-01-15
申请号：EP10781347
申请日：2010-05-28
发明人： PIPKIN JAMES D , MACHATHA STEPHEN G
CPC分类号： A61K31/198 , A61K9/0019 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： The present invention is directed to pharmaceutical compositions comprising melphalan and a cyclodextrin derivative, and methods of making and using the same.
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7.发明公开PHARMACEUTICAL COMPOSITIONS COMPRISING PRASUGREL AND CYCLODEXTRIN DERIVATIVES AND METHODS OF MAKING AND USING THE SAME 有权药物组合物和PRASUGREL-环糊精衍生物，AND METHOD FOR生产和使用
公开(公告)号：EP2429291A4
公开(公告)日：2013-06-05
申请号：EP10775566
申请日：2010-05-13
IPC分类号： A01N43/04
CPC分类号： A61K31/4365 , A61K9/0019 , A61K47/6951 , B82Y5/00 , C08B37/0012 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
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8.发明公开PHARMACEUTICAL COMPOSITIONS COMPRISING PRASUGREL AND CYCLODEXTRIN DERIVATIVES AND METHODS OF MAKING AND USING THE SAME 有权药物组合物和PRASUGREL-环糊精衍生物，AND METHOD FOR生产和使用
公开(公告)号：EP2429291A1
公开(公告)日：2012-03-21
申请号：EP10775566.2
申请日：2010-05-13
IPC分类号： A01N43/04
CPC分类号： A61K31/4365 , A61K9/0019 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0012 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
摘要翻译： 本发明涉及药物组合物，包含普拉格雷和环糊精衍生物，以及制备和使用它们的方法。
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9.发明公开NASAL AND OPHTHALMIC DELIVERY OF AQUEOUS CORTICOSTEROID SOLUTIONS 有权鼻腔和眼部给药水性CORTICOSTEROIDLÖSUNGEN的
公开(公告)号：EP2173169A4
公开(公告)日：2010-08-04
申请号：EP08781216
申请日：2008-06-30
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： A61K31/55 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K31/335 , A61K31/506 , A61K31/56 , A61K31/57 , A61K31/58 , A61K31/715 , A61K31/724 , A61K45/06 , A61K47/40 , A61M31/00 , A61K2300/00
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10.发明公开TASTE-MASKED FORMULATIONS CONTAINING SERTRALINE AND SULFOALKYL ETHER CYCLODEXTRIN 审中-公开TASTE HIDDEN制剂舍曲林和磺烷基醚环糊精
公开(公告)号：EP1742535A4
公开(公告)日：2008-10-15
申请号：EP05804782
申请日：2005-04-19
发明人： MOSHER GEROLD L , GAYED ATEF A , WEDEL REBECCA L
IPC分类号： A01N43/04 , A61K31/137 , A61K31/715 , A61K31/724
CPC分类号： A61K31/715 , A61K9/0095 , A61K31/137 , A61K31/724 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
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