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1.发明授权PHARMACEUTICAL COMPOSITIONS COMPRISING PRASUGREL AND CYCLODEXTRIN DERIVATIVES AND METHODS OF MAKING AND USING THE SAME 有权药物组合物和PRASUGREL-环糊精衍生物，AND METHOD FOR生产和使用
公开(公告)号：EP2429291B1
公开(公告)日：2016-07-06
申请号：EP10775566.2
申请日：2010-05-13
CPC分类号： A61K31/4365 , A61K9/0019 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0012 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
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2.发明公开PHARMACEUTICAL COMPOSITIONS COMPRISING PRASUGREL AND CYCLODEXTRIN DERIVATIVES AND METHODS OF MAKING AND USING THE SAME 有权药物组合物和PRASUGREL-环糊精衍生物，AND METHOD FOR生产和使用
公开(公告)号：EP2429291A1
公开(公告)日：2012-03-21
申请号：EP10775566.2
申请日：2010-05-13
IPC分类号： A01N43/04
CPC分类号： A61K31/4365 , A61K9/0019 , A61K47/40 , A61K47/6951 , B82Y5/00 , C08B37/0012 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.
摘要翻译： 本发明涉及药物组合物，包含普拉格雷和环糊精衍生物，以及制备和使用它们的方法。
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公开(公告)号：EP2434886B1
公开(公告)日：2019-10-16
申请号：EP10781347.9
申请日：2010-05-28
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4.发明公开INJECTABLE MELPHALAN COMPOSITIONS COMPRISING A CYCLODEXTRIN DERIVATIVE AND METHODS OF MAKING AND USING THE SAME 有权注射马法兰了包含生产和使用它们的环糊精衍生物和方法
公开(公告)号：EP2434886A1
公开(公告)日：2012-04-04
申请号：EP10781347.9
申请日：2010-05-28
IPC分类号： A01N43/04
摘要： The present invention is directed to pharmaceutical compositions comprising melphalan and a cyclodextrin derivative, and methods of making and using the same.
摘要翻译： 本发明涉及药物组合物，包含美法仑和环糊精衍生物，以及制备和使用它们的方法。
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5.发明公开FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE 审中-公开制剂氯吡格雷和磺烷基醚环糊精及其使用方法
公开(公告)号：EP2152078A1
公开(公告)日：2010-02-17
申请号：EP08769199.4
申请日：2008-04-26
发明人： MOSHER, Gerold, L. , WEDEL, Rebecca, L. , JOHNSON, Karen, T. , MACHATHA, Stephen, G. , COWEE, Jane, A. , CUSHING, Daniel, J.
IPC分类号： A01N43/42 , A61K31/44 , A61K31/715
CPC分类号： A61K31/737 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4365 , A61K31/44 , A61K31/724 , A61K31/727 , A61K45/06 , A61K47/40 , A61K47/6951 , B82Y5/00 , A61K2300/00
摘要： The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
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