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1.发明公开ANTI-ITGA3 ANTIBODIES, ACTIVATABLE ANTI-ITGA3 ANTIBODIES, AND METHODS OF USE THEREOF 审中-公开抗ITGA3抗体，活化抗ITGA3抗体及其使用方法
公开(公告)号：EP3292151A1
公开(公告)日：2018-03-14
申请号：EP16722507.7
申请日：2016-05-04
发明人： SAGERT, Jason Gary , TERRETT, Jonathan Alexander , DESNOYERS, Luc Roland , SINGH, Shweta , WEAVER, Annie Yang
CPC分类号： C07K16/2839 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K7/08 , C07K16/2842 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/50
摘要： The invention relates generally to antibodies that bind ITGa3, activatable antibodies that specifically bind to ITGa3 and methods of making and using these anti-ITGa3 antibodies and anti-ITGa3 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：EP3708585A1
公开(公告)日：2020-09-16
申请号：EP20155149.6
申请日：2016-05-04
发明人： WEST, James William , SAGERT, Jason Gary , TERRETT, Jonathan Alexander , WEAVER, Annie Yang , DESNOYERS, Luc Roland , SINGH, Shweta
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395 , A61K47/68
摘要： The invention relates generally to an-tibodies that bind CD166, activatable antibodies that specifically bind to CD 166 and methods of making and using these anti-CD166 antibodies and an-ti-CD166 activatable antibodies in a variety of thera-peutic, diagnostic and prophylactic indications.
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公开(公告)号：EP4029880A1
公开(公告)日：2022-07-20
申请号：EP21211176.9
申请日：2016-05-04
发明人： SAGERT, Jason Gary , TIPTON, Kimberly Ann , TERRETT, Jonathan Alexander , SINGH, Shweta , WEAVER, Annie Yang , DESNOYERS, Luc Roland
摘要： The invention relates generally to antibodies that bind CD71, activatable antibodies that specifically bind to CD71 and methods of making and using these anti-CD71 antibodies and anti-CD71 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：EP3292150B1
公开(公告)日：2020-02-05
申请号：EP16722502.8
申请日：2016-05-04
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5.发明公开ANTI-CD166 ANTIBODIES, ACTIVATABLE ANTI-CD166 ANTIBODIES, AND METHODS OF USE THEREOF 审中-公开抗CD166抗体，活化抗CD166抗体及其使用方法
公开(公告)号：EP3292150A1
公开(公告)日：2018-03-14
申请号：EP16722502.8
申请日：2016-05-04
发明人： WEST, James William , SAGERT, Jason Gary , TERRETT, Jonathan Alexander , WEAVER, Annie Yang , DESNOYERS, Luc Roland , SINGH, Shweta
CPC分类号： C07K16/2803 , A61K31/537 , A61K47/6873 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/50 , C07K2319/55
摘要： The invention relates generally to antibodies that bind CD166, activatable antibodies that specifically bind to CD166 and methods of making and using these anti-CD166 antibodies and anti-CD166 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：EP3592775A1
公开(公告)日：2020-01-15
申请号：EP18713528.0
申请日：2018-03-09
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7.发明公开ANTI-CD71 ANTIBODIES, ACTIVATABLE ANTI-CD71 ANTIBODIES, AND METHODS OF USE THEREOF 审中-公开抗CD71抗体，活化型抗CD71抗体及其使用方法
公开(公告)号：EP3292149A2
公开(公告)日：2018-03-14
申请号：EP16722495.5
申请日：2016-05-04
发明人： SAGERT, Jason Gary , TIPTON, Kimberly Ann , TERRETT, Jonathan Alexander , SINGH, Shweta , WEAVER, Annie Yang , DESNOYERS, Luc Roland
CPC分类号： C07K16/2881 , A61K39/3955 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K49/0032 , A61K49/0058 , A61K2039/505 , A61P35/00 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/50
摘要： The invention relates generally to antibodies that bind CD71, activatable antibodies that specifically bind to CD71 and methods of making and using these anti-CD71 antibodies and anti-CD71 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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8.发明公开MATRIX METALLOPROTEASE-CLEAVABLE AND SERINE PROTEASE CLEAVABLE SUBSTRATES AND METHODS OF USE THEREOF 审中-公开基质金属蛋白酶可切割的和丝氨酸蛋白酶可切割的基质及其使用方法
公开(公告)号：EP3247393A1
公开(公告)日：2017-11-29
申请号：EP16704511.1
申请日：2016-01-20
发明人： MOORE, Stephen James , NGUYEN, Margaret Thy Luu , HOSTETTER, Daniel R. , VASILJEVA, Olga , SAGERT, Jason Gary , TERRETT, Jonathan Alexander , WEST, James William
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/28 , A61K38/05 , A61K2039/505 , A61K2039/507 , C07K7/08 , C07K14/00 , C07K16/2863 , C07K16/2896 , C07K2319/50
摘要： The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease, and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease in a variety of therapeutic, diagnostic and prophylactic indications.
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