公开(公告)号：EP0858992A4

公开(公告)日：1999-02-10

申请号：EP96928684

申请日：1996-08-29

申请人： DAIICHI SEIYAKU CO ,  SUMITOMO CHEMICAL CO

发明人： EBATA TSUTOMU ,  AKIBA TOSHIFUMI ,  IKEYA TAKANOBU ,  WAKITA RYUHEI ,  SASAKI MIKIO

IPC分类号： B01J31/16 ,  C07B53/00 ,  C07B61/00 ,  C07C67/347 ,  C07C69/74 ,  C07C231/12 ,  C07C231/18 ,  C07C233/58 ,  C07C255/56 ,  C07C327/24

CPC分类号： C07C327/24 ,  C07C67/347 ,  C07C231/12 ,  C07C231/18 ,  C07C2601/02 ,  C07C69/74

摘要： A process for producing compounds represented by general formula (1) which comprises reacting a compound represented by the general formula CH2 = CXF with a compound represented by the general formula N2CHCOR in the presence of a catalyst containing an atom of a transition metal of the group 8, etc., and an optically active ligand of carboxylic acid or amide type to thereby form preferentially a stereoisomer of the compound of formula (1) having the S-configuration at the 1-position, wherein X represents chloro, etc.; and R represents alkyloxy, amino, etc.

摘要翻译： 一种制备由以下通式（I）表示的化合物的方法，其中X表示氯原子或其它，R表示烷氧基，氨基或其它，其包括使式-CH 2 = CXF表示的化合物与 在含有第8族的过渡金属的金属原子的催化剂和手性羧酸型或酰胺型配体的存在下，通式为N 2 CHCOR表示的化合物，以优先获得通式化合物的立体异构体（ I），其中1位上的立体化学构型是S-构型

公开(公告)号：EP0712831A4

公开(公告)日：1996-09-25

申请号：EP94923063

申请日：1994-08-03

申请人： DAIICHI SEIYAKU CO

发明人： AKIBA TOSHIFUMI ,  IKEYA TAKANOBU ,  KAWANISHI HIROFUMI ,  YUKIMOTO YUSUKE ,  KAMIHARA SHINJI ,  EBATA TSUTOMU

IPC分类号： C07C51/377 ,  C07C67/317 ,  C07C61/15 ,  C07C51/347 ,  C07C69/74

CPC分类号： C07C51/377 ,  C07C67/317 ,  C07C61/15 ,  C07C69/74

摘要： A convenient process for producing a compound represented by general formula (2) by the catalytic hydrogenolysis of a compound represented by general formula (1) or (3) in the presence of a base, wherein R represents hydrogen or C1-C4 alkyl; and X represents chlorine or bromine. The obtained compound can be used as an intermediate for producing medicines.