专利检索 ap:("DANA FARBER CANCER INST INC" OR "UNIV EMORY") AND inv:"CARR FRANCIS J" 第 1 页

1.

发明公开
HUMAN ANTI-PD-1, PD-L1, AND PD-L2 ANTIBODIES AND USES THEREFOR 有权
标题翻译：人PD1，PD-L1和PD-L2抗体和其应用

公开(公告)号：EP2342226A4

公开(公告)日：2012-11-28

申请号：EP09816950

申请日：2009-09-25

申请人： DANA FARBER CANCER INST INC , UNIV EMORY

发明人： FREEMAN GORDON J , AHMED RAFI , JONES TIMOTHY D , CARR FRANCIS J , GREGSON JAMES P

IPC分类号： C07K16/28 , A61K39/395 , A61P31/00 , A61P35/00

CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2818 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/74 , C07K2317/76 , C07K2317/92

摘要： The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.