公开(公告)号：EP2996677A1

公开(公告)日：2016-03-23

申请号：EP14801516.7

申请日：2014-05-16

申请人： DCB-USA LLC ,  National Chung-Hsing University

发明人： LAI, Ping-Shan ,  HSU, Chia-Yen

IPC分类号： A61K9/14 ,  A61K47/30 ,  A61K49/12

摘要： Disclosed herein are photosensitizer particle contrast agents suitable for medical imaging and/or photodynamic therapy. The photosensitizer particle contrast agent has a shell and a core encased by the shell. The shell consists essentially of multiple photosensitizer conjugates. Each photosensitizer conjugate consists of a photosensitizer and at least one biodegradable polymer covalently bound to the photosensitizer. According to certain examples, the core has an echogenic contrast-enhancing material loaded therein. In alternative examples, the photosensitizer of at least one of the multiple photosensitizer conjugates has a magnetic contrast-enhancing agent, e.g., a paramagnetic ion, chelated thereto. Also disclosed herein are methods for medical imaging which use imaging compositions containing the photosensitizer particle contrast agents taught in the present disclosure.

摘要翻译： 本文公开了适用于医学成像和/或光动力疗法的光敏剂颗粒造影剂。 光敏剂颗粒造影剂具有由壳包裹的壳和芯。 壳基本上由多个光敏剂缀合物组成。 每个光敏剂共轭物由光敏剂和共价结合到光敏剂上的至少一种可生物降解的聚合物组成。 根据某些实例，芯具有装载在其中的回声对比增强材料。 在替代实例中，多个光敏剂共轭物中的至少一个的光敏剂具有与其螯合的磁性对比度增强剂，例如顺磁性离子。 本文还公开了使用含有本发明中教导的光敏剂颗粒造影剂的成像组合物的医学成像方法。

公开(公告)号：EP2996677B1

公开(公告)日：2019-11-20

申请号：EP14801516.7

申请日：2014-05-16

申请人： National Chung-Hsing University

发明人： LAI, Ping-Shan ,  HSU, Chia-Yen

IPC分类号： A61K41/00 ,  A61K9/14 ,  A61K47/30 ,  A61K49/12 ,  A61K47/59 ,  A61K47/69