公开(公告)号：EP1617859A1

公开(公告)日：2006-01-25

申请号：EP04730606.3

申请日：2004-04-30

申请人： DEBIOPHARM S.A.

发明人： PORCHET, Hervé ,  HEIMGARTNER, Frédéric ,  CURDY, Catherine ,  DUCREY, Bertrand

IPC分类号： A61K38/09 ,  A61K31/565 ,  A61K9/16 ,  A61P13/08 ,  A61P35/00

CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/5084 ,  A61K31/56 ,  A61K31/565 ,  A61K38/09 ,  A61K38/24 ,  A61K2300/00

摘要： The present invention relates to compositions comprising two sustained release formulations, the first being capable of releasing a gonadotropin releasing hormone composition and the second an estrogenic composition. The compositions of the invention can be employed for an improved androgen deprivation therapy of prostate cancer, in which therapy loss of bone mineral density and the occurrence and severity of hot flashes are minimized through the maintenance of a minimally adequate estrogen level.