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公开(公告)号：EP1724287A4
公开(公告)日：2010-10-27
申请号：EP05720011
申请日：2005-03-04
发明人： IKEYA HITOSHI , MORIKAWA TADASHI , TAKAHASHI KOICHI , TAMURA TATSUYA , OKAMACHI AKIRA , ISHIZAWA TAKENORI , SATO HARUHIKO , HIGUCHI YOSHINOBU
IPC分类号： C08B37/08 , A61K31/519 , A61K47/48 , A61P19/02 , C07D475/10 , C07K5/00 , C07K9/00
CPC分类号： C08B37/0072 , A61K47/61 , A61K47/65 , C07D475/08 , C07K9/003
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
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公开(公告)号：EP1739097A4
公开(公告)日：2010-12-08
申请号：EP05727780
申请日：2005-04-01
发明人： IKEYA HITOSHI , MORIKAWA TADASHI , TAKAHASHI KOICHI , IZUTANI NORIYUKI , TAMURA TATSUYA , OKAMACHI AKIRA , ISHIZAWA TAKENORI , SATO HARUHIKO , HIGUCHI YOSHINOBU , KATO TATSUYA , HONMA AKIE
IPC分类号： A61K47/48 , A61K31/519 , A61P19/02 , C07D475/08 , C07D475/10 , C07K5/00 , C08B37/08
CPC分类号： C08L5/08 , A61K31/519 , A61K47/61 , A61K47/65 , C07D475/08 , C08B37/0072
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
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